Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joris H Hageman"'
Autor:
Yannik Bollen, Joris H Hageman, Petra van Leenen, Lucca L M Derks, Bas Ponsioen, Julian R Buissant des Amorie, Ingrid Verlaan-Klink, Myrna van den Bos, Leon W M M Terstappen, Ruben van Boxtel, Hugo J G Snippert
Publikováno v:
PLoS Biology, Vol 20, Iss 1, p e3001527 (2022)
CRISPR-associated nucleases are powerful tools for precise genome editing of model systems, including human organoids. Current methods describing fluorescent gene tagging in organoids rely on the generation of DNA double-strand breaks (DSBs) to stimu
Externí odkaz:
https://doaj.org/article/cd66eca306e549c4a4b1983de5881ebb
Autor:
Esther Strating, Mathijs P. Verhagen, Emerens Wensink, Ester Dünnebach, Liza Wijler, Itziar Aranguren, Alberto Sanchez De la Cruz, Niek A. Peters, Joris H. Hageman, Mirjam M. C. van der Net, Susanne van Schelven, Jamila Laoukili, Riccardo Fodde, Jeanine Roodhart, Stefan Nierkens, Hugo Snippert, Martijn Gloerich, Inne Borel Rinkes, Sjoerd G. Elias, Onno Kranenburg
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPoor prognosis in colon cancer is associated with a high content of cancer-associated fibroblasts (CAFs) and an immunosuppressive tumor microenvironment. The relationship between these two features is incompletely understood. Here, we aimed
Externí odkaz:
https://doaj.org/article/90ab2b9cb2c4478f87f361dda37eab04
Autor:
Hugo J.G. Snippert, Onno Kranenburg, Michiel Vermeulen, Jacco van Rheenen, Martijn Gloerich, Prisca Liberali, Inne H.M. Borel Rinkes, Ingrid Verlaan-Klink, Joris H. Hageman, Gustavo de Medeiros, Mirjam C. van der Net, Arianna Fumagalli, Lisa van Voorthuijsen, Rik G.H. Lindeboom, Koen C. Oost, Niek A. Peters, Maria C. Heinz
Supplementary Data from Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c4c4232fb540192e9921ef70f78607
https://doi.org/10.1158/0008-5472.22431123
https://doi.org/10.1158/0008-5472.22431123
Autor:
Hugo J.G. Snippert, Onno Kranenburg, Michiel Vermeulen, Jacco van Rheenen, Martijn Gloerich, Prisca Liberali, Inne H.M. Borel Rinkes, Ingrid Verlaan-Klink, Joris H. Hageman, Gustavo de Medeiros, Mirjam C. van der Net, Arianna Fumagalli, Lisa van Voorthuijsen, Rik G.H. Lindeboom, Koen C. Oost, Niek A. Peters, Maria C. Heinz
Micrometastases of colorectal cancer can remain dormant for years prior to the formation of actively growing, clinically detectable lesions (i.e., colonization). A better understanding of this step in the metastatic cascade could help improve metasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49935a71331f7c12f1dfc920e1314641
https://doi.org/10.1158/0008-5472.c.6513804
https://doi.org/10.1158/0008-5472.c.6513804
Autor:
Maria C. Heinz, Niek A. Peters, Koen C. Oost, Rik G.H. Lindeboom, Lisa van Voorthuijsen, Arianna Fumagalli, Mirjam C. van der Net, Gustavo de Medeiros, Joris H. Hageman, Ingrid Verlaan-Klink, Inne H.M. Borel Rinkes, Prisca Liberali, Martijn Gloerich, Jacco van Rheenen, Michiel Vermeulen, Onno Kranenburg, Hugo J.G. Snippert
Publikováno v:
Cancer Research, 82, 1953-1968
Cancer Research, 82, 10, pp. 1953-1968
Cancer Research, 82, 10, pp. 1953-1968
Micrometastases of colorectal cancer can remain dormant for years prior to the formation of actively growing, clinically detectable lesions (i.e., colonization). A better understanding of this step in the metastatic cascade could help improve metasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ee094c01da174dcd6d0aa74af53634
http://hdl.handle.net/2066/250973
http://hdl.handle.net/2066/250973
Autor:
Jelte van der Vaart, Joris H. Hageman, Hans Clevers, Hugo J. Snippert, Maria C. Heinz, Kai Kretzschmar
Publikováno v:
Developmental Cell
Damage to the intestinal stem cell niche can result from mechanical stress, infections, chronic inflammation or cytotoxic therapies. Progenitor cells can compensate for insults to the stem cell population through dedifferentiation. The microenvironme
Autor:
Lisanne E. Nijman, Cornelis J A Punt, Khalid El Makrini, Erik van Dijk, Bauke Ylstra, Louis Vermeulen, Rebecca C. Fitzgerald, Daniël M. Miedema, Jurriaan B. Tuynman, Tom van den Bosch, Jan Paul Medema, Geert J. P. L. Kops, Hendrik F. van Essen, Michiel Boekhout, Joris H. Hageman, Kristiaan J. Lenos, Hugo J. Snippert, Nico Lansu
Publikováno v:
Nature communications, 12(1):3188. Nature Publishing Group
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, 12(1). Nature Publishing Group
van Dijk, E, van den Bosch, T, Lenos, K J, el Makrini, K, Nijman, L E, van Essen, H F B, Lansu, N, Boekhout, M, Hageman, J H, Fitzgerald, R C, Punt, C J A, Tuynman, J B, Snippert, H J G, Kops, G J P L, Medema, J P, Ylstra, B, Vermeulen, L & Miedema, D M 2021, ' Chromosomal copy number heterogeneity predicts survival rates across cancers ', Nature Communications, vol. 12, no. 1, 3188 . https://doi.org/10.1038/s41467-021-23384-6
Nature Communications, 12(1):3188. Nature Publishing Group
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, 12(1). Nature Publishing Group
van Dijk, E, van den Bosch, T, Lenos, K J, el Makrini, K, Nijman, L E, van Essen, H F B, Lansu, N, Boekhout, M, Hageman, J H, Fitzgerald, R C, Punt, C J A, Tuynman, J B, Snippert, H J G, Kops, G J P L, Medema, J P, Ylstra, B, Vermeulen, L & Miedema, D M 2021, ' Chromosomal copy number heterogeneity predicts survival rates across cancers ', Nature Communications, vol. 12, no. 1, 3188 . https://doi.org/10.1038/s41467-021-23384-6
Nature Communications, 12(1):3188. Nature Publishing Group
Survival rates of cancer patients vary widely within and between malignancies. While genetic aberrations are at the root of all cancers, individual genomic features cannot explain these distinct disease outcomes. In contrast, intra-tumour heterogenei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c5aadebea81d9f17d09ab04b8e9c95
https://www.repository.cam.ac.uk/handle/1810/324542
https://www.repository.cam.ac.uk/handle/1810/324542
Autor:
Erik van Dijk, Tom van den Bosch, Kristiaan J. Lenos, Khalid El Makrini, Lisanne E. Nijman, Hendrik F. B. van Essen, Nico Lansu, Michiel Boekhout, Joris H. Hageman, Rebecca C. Fitzgerald, Cornelis J. A. Punt, Jurriaan B. Tuynman, Hugo J. G. Snippert, Geert J. P. L. Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M. Miedema
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Intratumour heterogeneity (ITH) is associated with worse prognosis in cancer, and efficient frameworks to measure it are needed. Here the authors develop a method to estimate copy number heterogeneity, and propose that it is driven by chromosomal ins
Externí odkaz:
https://doaj.org/article/264d1331d97845559b189b69b84d9dcb