Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Joris, de Wit"'
Autor:
Konstantina Liouta, Malgorzata Lubas, Vasika Venugopal, Julia Chabbert, Caroline Jeannière, Candice Diaz, Matthieu Munier, Béatrice Tessier, Stéphane Claverol, Alexandre Favereaux, Matthieu Sainlos, Joris de Wit, Mathieu Letellier, Olivier Thoumine, Ingrid Chamma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Synapses are organized into nanocolumns that control synaptic transmission efficacy through precise alignment of postsynaptic neurotransmitter receptors and presynaptic release sites. Recent evidence show that Leucine-Rich Repeat Transmembra
Externí odkaz:
https://doaj.org/article/d5a1d8cd3d9f4fed909f30b4de23a76b
Autor:
Keimpe Wierda, Hajnalka Nyitrai, Amélie Lejeune, Ine Vlaeminck, Elke Leysen, Tom Theys, Joris de Wit, Pierre Vanderhaeghen, Baptiste Libé-Philippot
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103313- (2024)
Summary: Cerebral cortex biopsies enable the investigation of native developing and mature human brain tissue. Here, we present a protocol to process human cortical biopsies from the surgical theater to the laboratory. We describe steps for the prepa
Externí odkaz:
https://doaj.org/article/37763152edc449bb9bab7fe94e751da0
Autor:
Andrea Toledo, Mathieu Letellier, Giorgia Bimbi, Béatrice Tessier, Sophie Daburon, Alexandre Favereaux, Ingrid Chamma, Kristel Vennekens, Jeroen Vanderlinden, Matthieu Sainlos, Joris de Wit, Daniel Choquet, Olivier Thoumine
Publikováno v:
eLife, Vol 11 (2022)
MDGA molecules can bind neuroligins and interfere with trans-synaptic interactions to neurexins, thereby impairing synapse development. However, the subcellular localization and dynamics of MDGAs, or their specific action mode in neurons remain uncle
Externí odkaz:
https://doaj.org/article/ed4ed58b731048d6a93d60b138a1317d
Autor:
Nuno Apóstolo, Samuel N. Smukowski, Jeroen Vanderlinden, Giuseppe Condomitti, Vasily Rybakin, Jolijn ten Bos, Laura Trobiani, Sybren Portegies, Kristel M. Vennekens, Natalia V. Gounko, Davide Comoletti, Keimpe D. Wierda, Jeffrey N. Savas, Joris de Wit
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Mossy fiber synapses are key in CA3 microcircuit function. Here, the authors profile the mossy fiber synapse proteome and cell-surface interactome. They uncover a diverse repertoire of cell-surface proteins and identify the receptor IgSF8 as a regula
Externí odkaz:
https://doaj.org/article/73f057183b374a89915c293d2ed3556b
Autor:
Heather C. Rice, Gabriele Marcassa, Iordana Chrysidou, Katrien Horré, Tracy L. Young-Pearse, Ulrike C. Müller, Takashi Saito, Takaomi C. Saido, Robert Vassar, Joris de Wit, Bart De Strooper
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-8 (2020)
Abstract The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer’s disease (AD) brains, is derived from sequential proteolytic processing of the Amyloid Precursor Protein (APP). However, the contribution of diffe
Externí odkaz:
https://doaj.org/article/5d37cdfea3af48149a9c42e6eadd3cbc
Autor:
Florian V De Rop, Joy N Ismail, Carmen Bravo González-Blas, Gert J Hulselmans, Christopher Campbell Flerin, Jasper Janssens, Koen Theunis, Valerie M Christiaens, Jasper Wouters, Gabriele Marcassa, Joris de Wit, Suresh Poovathingal, Stein Aerts
Publikováno v:
eLife, Vol 11 (2022)
Single-cell RNA-seq and single-cell assay for transposase-accessible chromatin (ATAC-seq) technologies are used extensively to create cell type atlases for a wide range of organisms, tissues, and disease processes. To increase the scale of these atla
Externí odkaz:
https://doaj.org/article/97dfa4c114864236a481414bf2dcdfcd
Autor:
Heike Blockus, Sebi V. Rolotti, Miklos Szoboszlay, Eugénie Peze-Heidsieck, Tiffany Ming, Anna Schroeder, Nuno Apostolo, Kristel M. Vennekens, Phinikoula S. Katsamba, Fabiana Bahna, Seetha Mannepalli, Goran Ahlsen, Barry Honig, Lawrence Shapiro, Joris de Wit, Attila Losonczy, Franck Polleux
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109828- (2021)
Summary: Synaptic connectivity within adult circuits exhibits a remarkable degree of cellular and subcellular specificity. We report that the axon guidance receptor Robo2 plays a role in establishing synaptic specificity in hippocampal CA1. In vivo,
Externí odkaz:
https://doaj.org/article/ca93291c525c4a8aa7c919fed9005f37
Autor:
Sofie Voet, Conor Mc Guire, Nora Hagemeyer, Arne Martens, Anna Schroeder, Peter Wieghofer, Carmen Daems, Ori Staszewski, Lieselotte Vande Walle, Marta Joana Costa Jordao, Mozes Sze, Hanna-Kaisa Vikkula, Delphine Demeestere, Griet Van Imschoot, Charlotte L. Scott, Esther Hoste, Amanda Gonçalves, Martin Guilliams, Saskia Lippens, Claude Libert, Roos E. Vandenbroucke, Ki-Wook Kim, Steffen Jung, Zsuzsanna Callaerts-Vegh, Patrick Callaerts, Joris de Wit, Mohamed Lamkanfi, Marco Prinz, Geert van Loo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central
Externí odkaz:
https://doaj.org/article/3142b0c70aa74f90b3c6f5b5f17ce066
Autor:
Anna Schroeder, Joris de Wit
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 4, Pp 1-9 (2018)
Brain circuits: Regulating synaptic connections Further analysis of synaptic proteins will provide insights into the functioning of neural circuits and associated brain disorders. The brain houses numerous highly specialized neuron types, which trans
Externí odkaz:
https://doaj.org/article/bab9128f28ec475d89629d26d4a25f76
Autor:
Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G. Herrmann, Rosemary J. Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L. Spires-Jones, Joris De Wit, Patrik Verstreken
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.
Externí odkaz:
https://doaj.org/article/29d0e0f57e0642e99099f85ef88b2518