Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Joris, Messens"'
Autor:
Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh, Joris Messens, Milos R. Filipovic, Hayley J. Sharpe, Eric Trépo, Wei Wu, Esteban N. Gurzov
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Fat accumulation, de novo lipogenesis, and glycolysis are key drivers of hepatocyte reprogramming and the consequent metabolic dysfunction-associated steatotic liver disease (MASLD). Here we report that obesity leads to dysregulated expressi
Externí odkaz:
https://doaj.org/article/47d15d12bd9c4154ade149ceeddbddb9
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
We review the newly classified ascorbate peroxidase–related (APX-R) proteins, which do not use ascorbate as electron donor to scavenge H2O2. We summarize recent discoveries on the function and the characterization of the APX-R protein of the green
Externí odkaz:
https://doaj.org/article/98313711a198424aa46d894ddd0ed168
Autor:
Israel Pérez-Chávez, John N. Koberstein, Julia Malo Pueyo, Eduardo H. Gilglioni, Didier Vertommen, Nicolas Baeyens, Daria Ezeriņa, Esteban N. Gurzov, Joris Messens
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111336- (2024)
Summary: HYlight is a genetically encoded fluorescent biosensor that ratiometrically monitors fructose 1,6-bisphosphate (FBP), a key glycolytic metabolite. Given the role of glucose in liver cancer metabolism, we expressed HYlight in human liver canc
Externí odkaz:
https://doaj.org/article/06432e888eac46fea648d28577fa9519
Autor:
Andrei Zhuravlev, Daria Ezeriņa, Julia Ivanova, Nikita Guriev, Natalia Pugovkina, Alla Shatrova, Nikolay Aksenov, Joris Messens, Olga Lyublinskaya
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103058- (2024)
A multitude of cellular metabolic and regulatory processes rely on controlled thiol reduction and oxidation mechanisms. Due to our aerobic environment, research preferentially focuses on oxidation processes, leading to limited tools tailored for inve
Externí odkaz:
https://doaj.org/article/a800d409ee7243d7a7d7e9d66ec2caae
Autor:
Daria Ezeriņa, Trung Nghia Vo, Ting Luo, Yvon Elkrim, Anna Escoda Suarez, Gaëtan Herinckx, Didier Vertommen, Damya Laoui, Jo A. Van Ginderachter, Joris Messens
Publikováno v:
Advances in Redox Research, Vol 9, Iss , Pp 100083- (2023)
Macrophages are characterised by their high plasticity and ability to adapt their phenotype and functionality in response to environmental cues, resulting in a spectrum of activation states the two extremes of which are M1 and M2. Reactive oxygen spe
Externí odkaz:
https://doaj.org/article/d752ac01d1864c7fab4934724cfc6004
Autor:
Anna Caccamo, Félix Vega de Luna, Khadija Wahni, Alexander N. Volkov, Jonathan Przybyla-Toscano, Antonello Amelii, Alexandre Kriznik, Nicolas Rouhier, Joris Messens, Claire Remacle
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 1946 (2023)
Recent phylogenetic studies have unveiled a novel class of ascorbate peroxidases called “ascorbate peroxidase-related” (APX-R). These enzymes, found in green photosynthetic eukaryotes, lack the amino acids necessary for ascorbate binding. This st
Externí odkaz:
https://doaj.org/article/2e35b886648446dab6250bb5266d145c
Autor:
Alexander I. Kostyuk, Maria-Armineh Tossounian, Anastasiya S. Panova, Marion Thauvin, Roman I. Raevskii, Daria Ezeriņa, Khadija Wahni, Inge Van Molle, Anastasia D. Sergeeva, Didier Vertommen, Andrey Yu. Gorokhovatsky, Mikhail S. Baranov, Sophie Vriz, Joris Messens, Dmitry S. Bilan, Vsevolod V. Belousov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
There are a lack of tools to study the dynamics of (pseudo)hypohalous acids in live cells. Here the authors report a genetically encoded fluorescent biosensor, Hypocrates, for (pseudo)hypohalous acids and their derivatives which they use in cells and
Externí odkaz:
https://doaj.org/article/9229963fe3634d69b8cb16d786e0e272
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Peroxiredoxin 2 (Prx2) was previously shown to transfer H2O2-derived oxidative equivalents to STAT3, generating disulfide-linked dimers and tetramers. Here the authors show that the interaction between Prx2 and STAT3 at the plasma membrane is mediate
Externí odkaz:
https://doaj.org/article/0437c00ea49c4b13ae922c900e305b00
Autor:
Ting Luo, Julia Malo Pueyo, Khadija Wahni, Charlotte Yvanoff, Tamas Lazar, Sébastien Pyr dit Ruys, Didier Vertommen, Daria Ezeriņa, Joris Messens
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102066- (2021)
Hydrogen peroxide (H2O2) acts as a signalling molecule by oxidising cysteine thiols in proteins. Recent evidence has established a role for cytosolic peroxiredoxins in transmitting H2O2-based oxidation to a multitude of target proteins. Moreover, it
Externí odkaz:
https://doaj.org/article/083e82b644994f1b935849fb7a32ce22
Autor:
Jesalyn Bolduc, Katarina Koruza, Ting Luo, Julia Malo Pueyo, Trung Nghia Vo, Daria Ezeriņa, Joris Messens
Publikováno v:
Redox Biology, Vol 42, Iss , Pp 101959- (2021)
Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a
Externí odkaz:
https://doaj.org/article/5227a2489ca8453281d36f7945f32bc4