Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Joris, Hoeks"'
Autor:
Emanuela Talamonti, Jelena Davegardh, Anastasia Kalinovich, Sten M.M. van Beek, Nodi Dehvari, Carina Halleskog, Hamza M. Bokhari, Dana S. Hutchinson, Seungmin Ham, Laura J. Humphrys, Nicola C. Dijon, Aikaterini Motso, Anna Sandstrom, Evelyn Zacharewicz, Ilga Mutule, Edgars Suna, Jana Spura, Karolina Ditrychova, Leigh A. Stoddart, Nicholas D. Holliday, Shane C. Wright, Volker M. Lauschke, Soren Nielsen, Camilla Scheele, Elizabeth Cheesman, Joris Hoeks, Peter Molenaar, Roger J. Summers, Benjamin Pelcman, Gopala K. Yakala, Tore Bengtsson
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101931- (2024)
Objective: Simultaneous activation of β2- and β3-adrenoceptors (ARs) improves whole-body metabolism via beneficial effects in skeletal muscle and brown adipose tissue (BAT). Nevertheless, high-efficacy agonists simultaneously targeting these recept
Externí odkaz:
https://doaj.org/article/3d4a3a5490234ea7a397025d54414624
Autor:
Vera H. W. de Wit-Verheggen, Vera B. Schrauwen-Hinderling, Kim Brouwers, Johanna A. Jörgensen, Gert Schaart, Anne Gemmink, Emmani B. M. Nascimento, Matthijs K. C. Hesselink, Joachim E. Wildberger, Patrique Segers, David Montaigne, Bart Staels, Patrick Schrauwen, Lucas Lindeboom, Joris Hoeks, Tineke van de Weijer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Cardiac energy status, measured as phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio with 31P-Magnetic Resonance Spectroscopy (31P-MRS) in vivo, is a prognostic factor in heart failure and is lowered in cardiometabolic disease. It has
Externí odkaz:
https://doaj.org/article/37b93e8a37d543e9a681f2a0a9782dad
Autor:
Sten M. M. van Beek, Yvonne M. H. Bruls, Froukje Vanweert, Ciarán E. Fealy, Niels J. Connell, Gert Schaart, Esther Moonen-Kornips, Johanna A. Jörgensen, Frédéric M. Vaz, Ellen T. H. C. Smeets, Peter J. Joris, Anne Gemmink, Riekelt H. Houtkooper, Matthijs K. C. Hesselink, Tore Bengtsson, Bas Havekes, Patrick Schrauwen, Joris Hoeks
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
β2-agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeostasis in rodents. Here the authors report that two-weeks of treatment with the β2-agonist clenbuterol improves insulin-stimulated glucose disposal in healthy
Externí odkaz:
https://doaj.org/article/c70a9895a6d34e0086372025f6878383
Autor:
Rodrigo Mancilla, Diego Pava‐Mejia, Nynke vanPolanen, Vera deWit, Maaike Bergman, Lotte Grevendonk, Johanna Jorgensen, Esther Kornips, Joris Hoeks, Matthijs K. C. Hesselink, Vera B. Schrauwen‐Hinderling
Publikováno v:
Physiological Reports, Vol 11, Iss 12, Pp n/a-n/a (2023)
Abstract Mitochondria are organelles that fuel cellular energy requirements by ATP formation via aerobic metabolism. Given the wide variety of methods to assess skeletal muscle mitochondrial capacity, we tested how well different invasive and noninva
Externí odkaz:
https://doaj.org/article/e51d1203343b480098a2feb69c51dec1
Autor:
Anne Gemmink, Sabine Daemen, Jakob Wefers, Jan Hansen, Dirk van Moorsel, Puji Astuti, Johanna A. Jorgensen, Esther Kornips, Gert Schaart, Joris Hoeks, Patrick Schrauwen, Matthijs K.C. Hesselink
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101727- (2023)
Objective: Mitochondrial network dynamics may play role in metabolic homeostasis. Whether mitochondrial network dynamics are involved in adaptations to day–night fluctuations in energy supply and demand is unclear. Here we visualized and quantified
Externí odkaz:
https://doaj.org/article/ec9b4e2549404d0f8c96da16498adf41
Autor:
Froukje Vanweert, Michael Neinast, Edmundo Erazo Tapia, Tineke van de Weijer, Joris Hoeks, Vera B. Schrauwen-Hinderling, Megan C. Blair, Marc R. Bornstein, Matthijs K. C. Hesselink, Patrick Schrauwen, Zoltan Arany, Esther Phielix
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Evidence from preclinical models suggest that lowering levels of branched chain amino acids (BCAA) improves glucose metabolism. Here the authors report that NaPB, an accelerator of BCAA catabolism, improves peripheral insulin sensitivity in patients
Externí odkaz:
https://doaj.org/article/13e10d35d6bc4308a78288bcc1294944
Autor:
Rodrigo F. Mancilla, Lucas Lindeboom, Lotte Grevendonk, Joris Hoeks, Tim R. Koves, Deborah M. Muoio, Patrick Schrauwen, Vera Schrauwen-Hinderling, Matthijs K.C. Hesselink
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
BACKGROUND At the onset of exercise, the speed at which phosphocreatine (PCr) decreases toward a new steady state (PCr on-kinetics) reflects the readiness to activate mitochondrial ATP synthesis, which is secondary to Acetyl-CoA availability in skele
Externí odkaz:
https://doaj.org/article/8e326707d1094bde815ebc4daea2ec00
Autor:
Yvo J.M. op den Kamp, Anne Gemmink, Marlies de Ligt, Bas Dautzenberg, Esther Kornips, Johanna A. Jorgensen, Gert Schaart, Russell Esterline, Diego A. Pava, Joris Hoeks, Vera B. Schrauwen-Hinderling, Sander Kersten, Bas Havekes, Timothy R. Koves, Deborah M. Muoio, Matthijs K.C. Hesselink, Jan Oscarsson, Esther Phielix, Patrick Schrauwen
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101620- (2022)
Objective: SGLT2 inhibitors increase urinary glucose excretion and have beneficial effects on cardiovascular and renal outcomes; the underlying mechanism may be metabolic adaptations due to urinary glucose loss. Here, we investigated the cellular and
Externí odkaz:
https://doaj.org/article/ce94ee3f45bd45f3ad7d1120c2287583
Autor:
Carlijn M. E. Remie, Michiel P. B. Moonen, Kay H. M. Roumans, Emmani B. M. Nascimento, Anne Gemmink, Bas Havekes, Gert Schaart, Esther Kornips, Peter J. Joris, Vera B. Schrauwen-Hinderling, Joris Hoeks, Sander Kersten, Matthijs K. C. Hesselink, Esther Phielix, Wouter D. van Marken Lichtenbelt, Patrick Schrauwen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Cold acclimation has been shown to have beneficial metabolic effects, including improved insulin sensitivity in patients with type 2 diabetes. Here the authors show that a mild cold acclimation regiment during which overt shivering was prevented did
Externí odkaz:
https://doaj.org/article/1c9d9177ddf8413ba3d5b7a5b26199f5
Autor:
Emmani B. M. Nascimento, Roland W. J. Hangelbroek, Guido J. E. J. Hooiveld, Joris Hoeks, Wouter D. Van Marken Lichtenbelt, Matthijs H. C. Hesselink, Patrick Schrauwen, Sander Kersten
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-11 (2020)
Abstract Background Cold acclimation and exercise training were previously shown to increase peripheral insulin sensitivity in human volunteers with type 2 diabetes. Although cold is a potent activator of brown adipose tissue, the increase in periphe
Externí odkaz:
https://doaj.org/article/33c10233b71f46f7b523a2e2271e6b14