Výsledky vyhledávání - "Jorine J L P Voss"

Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression

Autor: Vishnu C. Damalanka, Jorine J. L. P. Voss, Matthew W. Mahoney, Tina Primeau, Shunqiang Li, Lidija Klampfer, James W. Janetka

Publikováno v: J Med Chem

Hepatocyte growth factor (HGF), the ligand for the MET receptor tyrosine kinase, is a tumor-promoting factor that is abundant in the tumor microenvironment. Proteolytic activation of inactive pro-HGF by one or more of the serine endopeptidases matrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c77da84f0c8e368faa0e7e1541646b
https://doi.org/10.1021/acs.jmedchem.1c01671

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Peritubular Macrophages Are Recruited to the Testis of Peripubertal Rats After Mono-(2-Ethylhexyl) Phthalate Exposure and Is Associated With Increases in the Numbers of Spermatogonia

Autor: Shavini N. Hewage, Ross Gillette, John H. Richburg, Jorine J L P Voss, Richa Tiwary

Publikováno v: Toxicol Sci

Peripubertal exposure of male rodents to the phthalate metabolite mono-(2-ethylhexyl) phthalate (MEHP) causes testicular inflammation, spermatocyte apoptosis, and disruption of the blood-testis barrier. The MEHP-induced inflammatory response in the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab3c94c01f6ed8d2a114c92d39bbb00
https://doi.org/10.1093/toxsci/kfab059

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MEHP-induced rat testicular inflammation does not exacerbate germ cell apoptosis

Autor: Rashin Ghaffari, John H. Richburg, Angela R Stermer, Jorine J L P Voss, Richa Tiwary

Publikováno v: Reproduction. 156:35-46

The testis is an organ that maintains an immune suppressive environment. We previously revealed that exposure of pre-pubertal rats to an acute dose of a well-described Sertoli cell toxicant, mono-(2-ethylhexyl) phthalate (MEHP), leads to an accumulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b1e92efa816c108d0b55f5f94ce52d
https://doi.org/10.1530/rep-18-0093

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Mono-(2-ethylhexyl) phthalate-induced Sertoli cell injury stimulates the production of pro-inflammatory cytokines in Fischer 344 rats

Autor: Caitlin J. Murphy, Kristin R. Di Bona, Angela R Stermer, Jorine J L P Voss, Rashin Ghaffari, John H. Richburg

Publikováno v: Reproductive Toxicology. 69:150-158

Exposure of rodents to the Sertoli cell (SC) toxicant mono-(2-ethylhexyl) phthalate (MEHP) has been reported to trigger an infiltration of macrophages into the testis in an age- and species-dependent manner. Here we challenge the hypothesis that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735b481685c4251f11eadb1b5c87c2fd
https://doi.org/10.1016/j.reprotox.2017.02.013

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Peritubular macrophages and spermatogonia are sequentially increased in the testis of rats after mono-(2-ethylhexyl) phthalate exposure

Autor: Ross Gillette, Richa Tiwary, Jorine J L P Voss, Shavini N. Hewage, John H. Richburg

Peripubertal exposure to the phthalate metabolite mono-(2-ethylhexyl) phthalate (MEHP) in rodents causes testicular inflammation, spermatocyte apoptosis, and disruption of the blood-testis barrier. The MEHP-induced inflammation response includes an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c563d2c327e857a316bb5e18ca92fa0e

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Modulation of macrophage antitumor potential by apoptotic lymphoma cells

Autor: Tom C. Freeman, Catriona A. Ford, Bruno Giotti, Christopher D. Gregory, Jorine J L P Voss, Sofia Petrova, Pam Holland, Lynsey Melville, Margaret Paterson, John D. Pound

Publikováno v: Voss, J J L P, Ford, C A, Petrova, S, Melville, L, Paterson, M, Pound, J D, Holland, P, Giotti, B, Freeman, T C & Gregory, C D 2017, ' Modulation of macrophage antitumor potential by apoptotic lymphoma cells ', Cell Death and Differentiation, vol. 24, no. 6, pp. 971-983 . https://doi.org/10.1038/cdd.2016.132
Cell Death and Differentiation

In aggressive non-Hodgkin's lymphoma (NHL), constitutive apoptosis of a proportion of the tumor cell population can promote net tumor growth. This is associated with the accumulation of tumor-associated macrophages (TAMs) that clear apoptotic cells a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8e86c90a413a557e996710a08b2a60
https://www.pure.ed.ac.uk/ws/files/31032897/cdd2016132a.pdf

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Microenvironmental Effects of Cell Death in Malignant Disease

Autor: Christopher D. Gregory, Jorine J L P Voss, Catriona A. Ford

Publikováno v: Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy ISBN: 9783319394046

Although apoptosis is well recognized as a cell death program with clear anticancer roles, accumulating evidence linking apoptosis with tissue repair and regeneration indicates that its relationship with malignant disease is more complex than previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d64be163df93252d6250073c3429c4ae
https://doi.org/10.1007/978-3-319-39406-0_3

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Mono-(2-ethylhexyl) phthalate (MEHP)-induced neutrophil and macrophage infiltration into the testicular interstitium of peripubertal rats does not exacerbate MEHP-induced germ cell apoptosis

Autor: Jorine J. L. P. Voss, Angela R. Stermer, Rashin Ghaffari, Richa Tiwary, John H. Richburg

Publikováno v: The Journal of Immunology. 200:102.5-102.5

The testis is an immune-privileged organ that maintains an immune suppressive environment. We have previously shown that exposure of postnatal day (PND) 28 Fischer rats to an acute dose of the Sertoli cell toxicant MEHP leads to an accumulation of CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a2cbe28ae76c8fc6149320b432f560a
https://doi.org/10.4049/jimmunol.200.supp.102.5

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