Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1

Autor: Aimee du Chatinier, Zsolt Sebestyen, Jürgen Kuball, Stefan Nierkens, Anja Krippner-Heidenreich, Yuyan Lu, Ana P Lopes, Ester Dunnebach, Denise A M H van den Beemt, Sebastiaan van Heesch, Annelisa M. Cornel, Loutje van der Sman, Jip T van Dinter, Marta Arrabito, Marliek van Hoesel, Thomas A Kluiver, Noël M M Dautzenberg, Linde Dekker, Jorik M van Rijn, Juliane L Buhl, Farnaz Barneh, Luca Lo Nigro, Esther Hulleman, Jarno Drost, Olaf T Heidenreich, Weng Chuan Peng

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)

Human leukocyte antigen (HLA) restriction of conventional T-cell targeting introduces complexity in generating T-cell therapy strategies for patients with cancer with diverse HLA-backgrounds. A subpopulation of atypical, major histocompatibility comp

Externí odkaz: https://doaj.org/article/74ecceb9112048d6b772df7929f01087

High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium

Autor: Jorik M. van Rijn, Jens Eriksson, Jana Grüttner, Magnus Sundbom, Dominic-Luc Webb, Per M. Hellström, Staffan G. Svärd, Mikael E. Sellin

Publikováno v: mBio, Vol 13, Iss 1 (2022)

ABSTRACT Interactions between individual pathogenic microbes and host tissues involve fast and dynamic processes that ultimately impact the outcome of infection. Using live-cell microscopy, these dynamics can be visualized to study, e.g., microbe mot

Externí odkaz: https://doaj.org/article/ba3b486d43254a5a817abe796f7a9578

Erratum: DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells

Autor: Jorik M. van Rijn, Marliek van Hoesel, Cecilia de Heus, Anke H.M. van Vugt, Judith Klumperman, Edward E.S. Nieuwenhuis, Roderick H.J. Houwen, Sabine Middendorp

Publikováno v: Journal of Lipid Research, Vol 62, Iss , Pp 100126- (2021)

Externí odkaz: https://doaj.org/article/02e91a3f73974accaf6d9c57598a718c

High definition DIC imaging uncovers transient stages of pathogen infection cycles on the surface of human adult stem cell-derived intestinal epithelium

Autor: Dominic-Luc Webb, Mikael E. Sellin, Magnus Sundbom, Per M. Hellström, Jens Eriksson, Jorik M. van Rijn, Jana Grüttner, Staffan G. Svärd

Interactions between individual pathogenic microbes and host tissues involve fast and dynamic processes that ultimately impact the outcome of infection. Using live-cell microscopy, these dynamics can be visualized to study e.g. microbe motility, bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6a57a607e253ed509a732f0113df764
https://doi.org/10.1101/2021.08.24.457471

DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells

Autor: Sabine Middendorp, Jorik M. van Rijn, Edward E. S. Nieuwenhuis, Anke H.M. van Vugt, Judith Klumperman, Roderick H. J. Houwen, Marliek van Hoesel, Cecilia de Heus

Publikováno v: J Lipid Res
Journal of Lipid Research, 60(10), 1787. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, Vol 60, Iss 10, Pp 1787-1800 (2019)

Dietary lipids are taken up as FAs by the intestinal epithelium and converted by diacylglycerol acyltransferase (DGAT) enzymes into triglycerides, which are packaged in chylomicrons or stored in cytoplasmic lipid droplets (LDs). DGAT1-deficient patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5e4389fc69f24196300114ea505ac5
https://pubmed.ncbi.nlm.nih.gov/34626871