Výsledky vyhledávání - "Jori A L Wagenaars"

Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes

Autor: Gert Jan Scheffer, Martijn H. den Brok, Tonke K. Raaijmakers, Melissa Wassink, Gosse J. Adema, Stefan Nierkens, Marleen Ansems, Jori A. L. Wagenaars, Renske J.E. van den Bijgaart, Annemarie M.A. de Graaf

Publikováno v: Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer, 8
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer, 8, 1

BackgroundTumor ablation techniques, like cryoablation, are successfully used in the clinic to treat tumors. The tumor debris remaining in situ after ablation is a major antigen depot, including neoantigens, which are presented by dendritic cells (DC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc86edb950acb773bace4764fec2cf3f
https://pubmed.ncbi.nlm.nih.gov/32461350

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NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4(-/-) mice and Leigh syndrome patients: A stabilizing role for NDUFAF2

Autor: Leo G.J. Nijtmans, Mariël A.M. van den Brand, Jori A. L. Wagenaars, Leonid A. Sazanov, Werner J.H. Koopman, Jan A.M. Smeitink, Merel J. W. Adjobo-Hermans, Sjenet E. van Emst-de Vries, Mariusz R. Wieckowski, Richard J. Rodenburg, Peter H.G.M. Willems, Aleksandra Wojtala, Ria de Haas

Publikováno v: Biochimica et Biophysica Acta. Bioenergetics, 1861
Biochimica et Biophysica Acta. Bioenergetics, 1861, 8

Mutations in NDUFS4, which encodes an accessory subunit of mitochondrial oxidative phosphorylation (OXPHOS) complex I (CI), induce Leigh syndrome (LS). LS is a poorly understood pediatric disorder featuring brain-specific anomalies and early death. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbeb3235af78648702b370eecd47a8b4
https://hdl.handle.net/2066/220251

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Akademický článek

Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice.

Autor: Stefan Nierkens, Martijn H den Brok, Thijs Roelofsen, Jori A L Wagenaars, Carl G Figdor, Theo J Ruers, Gosse J Adema

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8368 (2009)

BackgroundThe TLR9 agonist CpG is increasingly applied in preclinical and clinical studies as a therapeutic modality to enhance tumor immunity. The clinical application of CpG appears, however, less successful than would be predicted from animal stud

Externí odkaz: https://doaj.org/article/9b71579ac2cc4de8ab648b64648303bf

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Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2

Autor: Werner J.H. Koopman, Renate L. M. Jansen, Sander Grefte, Peter H.G.M. Willems, Jori A. L. Wagenaars

Publikováno v: Biochimica et Biophysica Acta. Molecular Cell Research, 1853, 1606-14
Biochimica et Biophysica Acta. Molecular Cell Research, 1853, 7, pp. 1606-14
Biochimica et Biophysica Acta. C, Molecular Cell Research, 1853(7), 1606-1614
Biochimica et Biophysica Acta. C, Molecular Cell Research 1853 (2015) 7

Contains fulltext : 153908.pdf (Publisher’s version ) (Open Access) Rotenone (ROT) is a widely used inhibitor of complex I (CI), the first complex of the mitochondrial oxidative phosphorylation (OXPHOS) system. However, particularly at high concent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8754677357eb655ecf607a4009ee41
https://doi.org/10.1016/j.bbamcr.2015.03.010

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Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Publikováno v: Nature immunology, 17(4), 406. Nature Publishing Group
Nature Immunology, 17, 406-13
Nature Immunology, 17, 4, pp. 406-13
Nature immunology, 17(4), 406-413. Nature Publishing Group

Contains fulltext : 172049.pdf (Publisher’s version ) (Closed access) The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages in some patients, immunoparalysis may be encountered, which is associated with a poo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652629335af1749d0b6db0623e5e6c54
https://dspace.library.uu.nl/handle/1874/334612

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Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR-RAPTOR

Autor: Peter H.G.M. Willems, Jan A.M. Smeitink, Jori A. L. Wagenaars, Dania C. Liemburg-Apers, Werner J.H. Koopman

Publikováno v: Journal of Cell Science, 129, 23, pp. 4411-4423
Journal of Cell Science, 129, 4411-4423
ResearcherID

Contains fulltext : 172799.pdf (Publisher’s version ) (Open Access) Mitochondria play a central role in cellular energy production, and their dysfunction can trigger a compensatory increase in glycolytic flux to sustain cellular ATP levels. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5165e5670016ef4f8021680b9f0e7a0
https://doi.org/10.1242/jcs.194480

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Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation

Autor: Gosse J. Adema, Annemarie M.A. de Graaf, Marthe Minderman, Eric Onno Rijke, Mayank Thakur, Jori A. L. Wagenaars, Christian Büll, Melissa Wassink, Martijn H. den Brok, Schrier Carla Christina, Sebastian Amigorena

Publikováno v: Nature Communications, 7, 13324-13324
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications, 7, pp. 13324-13324
Nature Communications

Saponin-based adjuvants (SBAs) are being used in animal and human (cancer) vaccines, as they induce protective cellular immunity. Their adjuvant potency is a factor of inflammasome activation and enhanced antigen cross-presentation by dendritic cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed1273b02934123b3e96e31de75248c
http://hdl.handle.net/2066/171462

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