Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jori, Symons"'
Autor:
Ninée V. E. J. Buchholtz, Lucas E. Hermans, Chijioke N. Umunnakwe, Marieke M. Nühn, Regina Voss, Emma Need, Neeltje A. Kootstra, Irma Maurer, Dorien C. M. de Jong, Jori Symons, Hugo A. Tempelman, Annemarie M. J. Wensing, Monique Nijhuis
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe main obstacle to achieving an HIV-1 cure is the proviral reservoir. To promote equity in HIV cure strategies, it is crucial to study the viral reservoir of the predominant HIV-1 subtype C in both women and men. Therefore, we investiga
Externí odkaz:
https://doaj.org/article/cb7079436e894078b14b9014db465d08
Autor:
Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua M. L. Casan, Amit Kumar, Jori Symons, Jennifer M. Zerbato, Danielle Fong, Ilia Voskoboinik, Paul G. Ekert, Rajeev Rudraraju, Damian F. J. Purcell, Sharon R. Lewin, Joseph A. Trapani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Cas13b can be harnessed to target and degrade RNA transcripts inside a cellular environment. Here the authors reprogram Cas13b to target SARSCoV-2 transcripts in infected mammalian cells and reveal its resilience to variants thanks to single mismatch
Externí odkaz:
https://doaj.org/article/c9a22d0a72d14aecb6991c4771cee7a6
Autor:
Charline Bacchus-Souffan, Mark Fitch, Jori Symons, Mohamed Abdel-Mohsen, Daniel B Reeves, Rebecca Hoh, Mars Stone, Joseph Hiatt, Peggy Kim, Abha Chopra, Haelee Ahn, Vanessa A York, Daniel L Cameron, Frederick M Hecht, Jeffrey N Martin, Steven A Yukl, Simon Mallal, Paul U Cameron, Steven G Deeks, Joshua T Schiffer, Sharon R Lewin, Marc K Hellerstein, Joseph M McCune, Peter W Hunt
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009214 (2021)
The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral therapy (ART) has not yet been well characterized. In resting CD4 T cell subpopulations from 24 HIV-infected ART-suppressed and 6 HIV-uninfected individuals,
Externí odkaz:
https://doaj.org/article/1c92de8d5c364b769ed3f828c4efac4a
Autor:
Matthew J, Gartner, Carolin, Tumpach, Ashanti, Dantanarayana, Jared, Stern, Jennifer M, Zerbato, J Judy, Chang, Thomas A, Angelovich, Jenny L, Anderson, Jori, Symons, Steve G, Deeks, Jacqueline K, Flynn, Sharon R, Lewin, Melissa J, Churchill, Paul R, Gorry, Michael, Roche
Publikováno v:
AIDS. 37:247-257
Despite suppressive antiretroviral therapy (ART), HIV can persist in a diverse range of CD4+ T-cell subsets. Through longitudinal env sampling from people with HIV (PWH) on ART, we characterized the persistence and phenotypic properties of HIV envs o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0fa9ffd4c17c20f57d50db99b08140
https://doi.org/10.1097/qad.0000000000003424
https://doi.org/10.1097/qad.0000000000003424
Autor:
Marieke M, Nühn, Stephanie B H, Gumbs, Ninée V E J, Buchholtz, Lisanne M, Jannink, Lavina, Gharu, Lot D, de Witte, Annemarie M J, Wensing, Sharon R, Lewin, Monique, Nijhuis, Jori, Symons
Publikováno v:
Journal of Leukocyte Biology. 112:1297-1315
The most studied HIV eradication approach is the “shock and kill” strategy, which aims to reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of these cells by immune-mediated clearance or viral cytopathic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f22d7a0919165203d340fae8e780576
https://doi.org/10.1002/jlb.5vmr0122-046rrr
https://doi.org/10.1002/jlb.5vmr0122-046rrr
Autor:
Sharon R Lewin, Jori Symons, Ewa Czuba-Wojnilowicz, Frank Caruso, Christina Cortez-Jugo, Paula M. Cevaal, Abdalla Ali
Publikováno v:
ACS Nano. 15:3736-3753
T cells play an important role in immunity and repair and are implicated in diseases, including blood cancers, viral infections, and inflammation, making them attractive targets for the treatment and prevention of diseases. Over recent years, the adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::400acc5f4fa61bfc4a30c9fcefad1d60
https://doi.org/10.1021/acsnano.0c09514
https://doi.org/10.1021/acsnano.0c09514
Autor:
Alessia Amodio, Marco Cassani, Liviana Mummolo, Christina Cortez-Jugo, Sukhvir Kaur Bhangu, Jori Symons, Chantelle L. Ahlenstiel, Giancarlo Forte, Francesco Ricci, Anthony D. Kelleher, Sharon R. Lewin, Francesca Cavalieri, Frank Caruso
Real-time detection and nanoscale imaging of human immunodeficiency virus type 1 ribonucleic acid (HIV-1 RNA) in latently infected cells that persist in people living with HIV-1 on antiretroviral therapy in blood and tissue may reveal new insights ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e21436ba80da11a34976fed87ece8e
https://hdl.handle.net/2108/308190
https://hdl.handle.net/2108/308190
Autor:
Shwathy Ramesan, Jori Symons, Christina Cortez-Jugo, Leslie Y. Yeo, Amgad R. Rezk, Paula M. Cevaal
Publikováno v:
ACS applied bio materials. 4(3)
The internalization of therapeutic molecules into cells-a critical step in enabling a suite of autologous ex vivo gene and cell therapies-is highly regulated by the lipid barrier imposed by the cell membrane. Strategies to increase the efficiency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3935fdf1c491408ca70e71b88761a5ca
https://pubmed.ncbi.nlm.nih.gov/35014317
https://pubmed.ncbi.nlm.nih.gov/35014317
Autor:
Michiel Heron, Robert-Jan Lebbink, Stefan Nierkens, Tessa Reinders, Anniek A N Tanja, Patrique Praest, Yvonne M G van Os, Jori Symons, Rob Schuurman, L. Marije Hofstra, Dorien de Jong, Jeffrey M. Beekman, Lidewij W Rümke, Steven F. T. Thijsen, Monique Nijhuis, Femke C Groenveld, Annemarie M. J. Wensing
Publikováno v:
Open Forum Infectious Diseases
Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312426cf58a7ff9793e2392ab1e8f40d
https://doi.org/10.1093/ofid/ofab553
https://doi.org/10.1093/ofid/ofab553
Autor:
Steven F L van Lelyveld, Julia Drylewicz, Maaike Krikke, Ellen M Veel, Sigrid A Otto, Clemens Richter, Robin Soetekouw, Jan M Prins, Kees Brinkman, Jan Willem Mulder, Frank Kroon, Ananja Middel, Jori Symons, Annemarie M J Wensing, Monique Nijhuis, José A M Borghans, Kiki Tesselaar, Andy I M Hoepelman, MIRS study group
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132430 (2015)
The immunomodulatory effects of the CCR5-antagonist maraviroc might be beneficial in patients with a suboptimal immunological response, but results of different cART (combination antiretroviral therapy) intensification studies are conflicting. Theref
Externí odkaz:
https://doaj.org/article/3822b11de4db4781b6dfc3e0e6f04736