Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jorgen Kjaergaard"'
Publikováno v:
The Journal of Immunology. 201:782-791
Tumor hypoxia–driven accumulation of extracellular adenosine was shown to facilitate tumor evasion by engaging the immunosuppressive, intracellular cAMP-elevating A2 adenosine receptors (A2R) on tumor-reactive effector T cells, but there remains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406875ca42e4a62b4af13ca6a75ff88a
https://doi.org/10.4049/jimmunol.1700850
https://doi.org/10.4049/jimmunol.1700850
Publikováno v:
Clinical Cancer Research. 14:5947-5952
Cancerous tissue protection from tumor-recognizing CD8+ and CD4+ T cells (antitumor T cells) limits the therapeutic potential of immunotherapies. We propose that tumor protection is to a large extent due to (a) inhibition of antitumor T cells by hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0599d10d0cec655e5f1fe47fcfb34424
https://doi.org/10.1158/1078-0432.ccr-08-0229
https://doi.org/10.1158/1078-0432.ccr-08-0229
Autor:
Dmitriy Lukashev, Jeffrey L. Kutok, Shalini Sethumadhavan, Phaethon Philbrook, Michail V. Sitkovsky, Bryan Belikoff, Barry L. Karger, Ryan Cannici, Jorgen Kjaergaard, Robert K. Abbott, Eckhard R. Podack, Taylor H. Schreiber, Stephen M. Hatfield, Akio Ohta, Molly Thayer, Kami Ko, Scott J. Rodig, Edwin K. Jackson
Publikováno v:
Science Translational Medicine. 7
Antitumor T cells either avoid or are inhibited in hypoxic and extracellular adenosine-rich tumor microenvironments (TMEs) by A2A adenosine receptors. This may limit further advances in cancer immunotherapy. There is a need for readily available and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200e6276d18578281565bb4877f3b34b
https://doi.org/10.1126/scitranslmed.aaa1260
https://doi.org/10.1126/scitranslmed.aaa1260
Autor:
Rongxiu Zheng, Hidemasa Tamai, Hong-Ming Hu, Satoshi Watanabe, H Kuriyama, Peter A. Cohen, Gregory E. Plautz, Jorgen Kjaergaard, Suyu Shu, Andrew D. Weinberg
Publikováno v:
Cellular Immunology. 243:30-40
Dendritic-tumor heterokaryons generated by electrofusion are highly immunogenic. In animal studies, a single vaccination was therapeutic for tumors established in the lung, skin, and brain. However, effective therapy required a third signal which cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cea2a915eaf17b78d7a419e1009f0b5
https://doi.org/10.1016/j.cellimm.2006.11.002
https://doi.org/10.1016/j.cellimm.2006.11.002
Autor:
Marshall Strome, Samir S. Khariwala, Frederick Van Lente, Robert R. Lorenz, Jorgen Kjaergaard, Suyu Shu
Publikováno v:
The Laryngoscope. 116:814-820
Objective: Everolimus (RAD) is an mTOR inhibitor closely related to rapamycin. A potent immunosuppressive agent, it has also shown evidence of antineoplastic properties. SCC VII is a spontaneously arising murine squamous cell carcinoma line. This stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c87122e09af5b8ec6ea30e4dc089e0
https://doi.org/10.1097/01.mlg.0000210544.64659.35
https://doi.org/10.1097/01.mlg.0000210544.64659.35
Publikováno v:
Otolaryngology–Head and Neck Surgery. 132:755-764
Objective To establish the basis for use of allogeneic dendritic-tumor fusion cells. Study design Fusion cells were created by electrofusion. We used 2 allogeneic murine tumor lines (D5 and 4T1) that were virally transduced to express the antigen (β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fd8255ec93882fedba6a10bf75603e
https://doi.org/10.1016/j.otohns.2005.01.018
https://doi.org/10.1016/j.otohns.2005.01.018
Publikováno v:
Journal of Immunotherapy. 27:265-272
Dendritic cells (DCs) loaded with antigens can effectively stimulate host immune responses to syngeneic tumors, but there is considerable controversy as to which forms of antigen-loading are most immunogenic. Here, the authors compared immunotherapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1a0bef343675a4d6e61b9c98dc786e
https://doi.org/10.1097/00002371-200407000-00002
https://doi.org/10.1097/00002371-200407000-00002
Publikováno v:
Cellular Immunology. 225:65-74
Antigen presentation by dendritic cells (DCs) has the potential to elicit therapeutic immune responses against malignant tumors. One strategy utilizing DC-tumor fusion hybrids as cancer vaccine is particularly attractive because of polyclonal present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e9b8af07fbcd007458813dec3ab186
https://doi.org/10.1016/j.cellimm.2003.09.005
https://doi.org/10.1016/j.cellimm.2003.09.005
Autor:
Liaomin Peng, Jorgen Kjaergaard, Peter A. Cohen, Suyu Shu, Judith A. Drazba, Mohamed Awad, Gregory E. Plautz
Publikováno v:
The Journal of Immunology. 169:4811-4821
Tumor-specific effector T cells (TE) are naturally sensitized within the L-selectinlow (CD62Llow) fraction of tumor-draining lymph nodes (TDLN). Whether isolated from day 9 (D9) or day 12 (D12) TDLN, 5 million L-selectinlow TE could be culture activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0727d445173117f0de698c25502df470
https://doi.org/10.4049/jimmunol.169.9.4811
https://doi.org/10.4049/jimmunol.169.9.4811
Publikováno v:
Journal of Immunotherapy. 25:207-217
Recent studies have identified a unique population of CD4 + CD25 + regulatory T cells that is crucial for the prevention of spontaneous autoimmune diseases. Further studies demonstrated that depletion of CD4 + CD25 + T cells enhances immune responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e4f7b0a730ec2da196c9be16aba6f2
https://doi.org/10.1097/00002371-200205000-00003
https://doi.org/10.1097/00002371-200205000-00003