Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jorge S, Valadas"'
Autor:
Manisha Padmakumar, Steven Biesmans, Jorge S. Valadas, Jan R. Detrez, Gaëlle Gillet, Priscillia Bresler, Marie-Laure Clénet, Irena Kadiu
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Neuroscience drug discovery has faced significant challenges due to restricted access to relevant human cell models and limited translatability of existing preclinical findings to human pathophysiology. Induced pluripotent stem cells (iPSCs) have eme
Externí odkaz:
https://doaj.org/article/4e10a82de23d46c7890710e9bc03d4d9
Autor:
Marie-Laure Clénet, James Keaney, Gaëlle Gillet, Jorge S. Valadas, Julie Langlois, Alvaro Cardenas, Julien Gasser, Irena Kadiu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
NOD-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation amplified by pyroptotic innate immune cell death. In diseases characterized by non-cell autonomo
Externí odkaz:
https://doaj.org/article/8ebc97ff867d42c99a352b940efac384
Autor:
Julien Gasser, Gaelle Gillet, Jorge S. Valadas, Laura Rouvière, Apoorva Kotian, Wenqiang Fan, James Keaney, Irena Kadiu
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disease caused by CAG repeats in exon 1 of the HTT gene. A hallmark of HD along with other psychiatric and neurodegenerative diseases is alteration in the neuronal circu
Externí odkaz:
https://doaj.org/article/36f81fae85e74d06aa8c531767ce20bb
Autor:
Cedric Thues, Jorge S. Valadas, Liesbeth Deaulmerie, Ann Geens, Amit K. Chouhan, Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Michaela Bartusel, Rizwan Rehimi, Alvaro Rada-Iglesias, Patrik Verstreken, Hilde Van Esch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Circumferential skin creases (CSC-KT) is a rare polymalformative syndrome characterised by intellectual disability associated with skin creases on the limbs, and very characteristic craniofacial malformations. Previously, heterozygous and ho
Externí odkaz:
https://doaj.org/article/21a523c5582d4005ad24a2cf349d7f1b
Autor:
Katarzyna Miskiewicz, Liya E. Jose, Wondwossen M. Yeshaw, Jorge S. Valadas, Jef Swerts, Sebastian Munck, Fabian Feiguin, Bart Dermaut, Patrik Verstreken
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 94-102 (2014)
Presynaptic densities are specialized structures involved in synaptic vesicle tethering and neurotransmission; however, the mechanisms regulating their function remain understudied. In Drosophila, Bruchpilot is a major constituent of the presynaptic
Externí odkaz:
https://doaj.org/article/6538ed6ade044d899b33f4f541929ebe
Autor:
Joana E Coelho, Pedro eAlves, Paula M Canas, Jorge S Valadas, Vania L Batalha, Diana G Ferreira, Tatiana eShmidt, Joaquim Alexandre Ribeiro, Michael eBader, Rodrigo A Cunha, Frederico eSimões do Couto, Luisa V Lopes
Publikováno v:
Frontiers in Psychiatry, Vol 5 (2014)
Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia, activated by the neuromodulator adenosine, which interact with dopamine D2 receptors. Although this reciprocal antagonistic interaction is well established in motor
Externí odkaz:
https://doaj.org/article/6c5182f2b39245c2af7661390804b0d5
Autor:
Rizwan Rehimi, Amit K Chouhan, Joost Schymkowitz, Michaela Bartusel, Jorge S. Valadas, Ramon Duran-Romaña, Patrik Verstreken, Frederic Rousseau, Cedric Thues, Hilde Van Esch, Ann Geens, Alvaro Rada-Iglesias, Liesbeth Deaulmerie
Publikováno v:
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Circumferential skin creases (CSC-KT) is a rare polymalformative syndrome characterised by intellectual disability associated with skin creases on the limbs, and very characteristic craniofacial malformations. Previously, heterozygous and homozygous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b42b5c367711dd64d9075979ca9af48
Autor:
Giovanni Esposito, Patrik Verstreken, Susanna Raitano, Christine Klein, Jorge S. Valadas, Philip Seibler, Katarzyna Miskiewicz, Dirk Vandekerkhove, Liesbeth Deaulmerie
Publikováno v:
Neuron
Parkinson's disease patients report disturbed sleep patterns long before motor dysfunction. Here, in parkin and pink1 models, we identify circadian rhythm and sleep pattern defects and map these to specific neuropeptidergic neurons in fly models and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5e457caedb7e0da9e61b7d7cbfd6ce
https://lirias.kuleuven.be/handle/123456789/625080
https://lirias.kuleuven.be/handle/123456789/625080
Publikováno v:
Annals of the New York Academy of Sciences. 1338:16-37
Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by a loss of dopaminergic neurons in the substantia nigra, as well as in other brain areas. The currently available dopamine replacement therapy provides me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edbc3ad5819d268dbaaa011efac54745
https://doi.org/10.1111/nyas.12577
https://doi.org/10.1111/nyas.12577
Autor:
Patrik Verstreken, Fabian Feiguin, Liya E. Jose, Jef Swerts, Katarzyna Miskiewicz, Bart Dermaut, Jorge S. Valadas, Wondwossen M Yeshaw, Sebastian Munck
Publikováno v:
Cell reports, 8(1), 94-102. CELL PRESS
Cell Reports, Vol 8, Iss 1, Pp 94-102 (2014)
CELL REPORTS
Cell Reports, Vol 8, Iss 1, Pp 94-102 (2014)
CELL REPORTS
Presynaptic densities are specialized structures involved in synaptic vesicle tethering and neurotransmission; however, the mechanisms regulating their function remain understudied. In Drosophila, Bruchpilot is a major constituent of the presynaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a52c469730bd6afb30025410cf7158d