Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jorge Ruiz‐Orera"'
Autor:
Olga Boix, Marion Martinez, Santiago Vidal, Marta Giménez-Alejandre, Lluís Palenzuela, Laura Lorenzo-Sanz, Laura Quevedo, Olivier Moscoso, Jorge Ruiz-Orera, Pilar Ximénez-Embún, Nikaoly Ciriaco, Paolo Nuciforo, Camille Stephan-Otto Attolini, M. Mar Albà, Javier Muñoz, Tian V. Tian, Ignacio Varela, Ana Vivancos, Santiago Ramón y Cajal, Purificación Muñoz, Carmen Rivas, María Abad
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Small proteins encoded by previously assumed non-coding RNAs can have cell regulatory functions. Here the authors report that TINCR lncRNA encodes pTINCR, a ubiquitin-like protein (UBL) that promotes epithelial differentiation through the SUMOylation
Externí odkaz:
https://doaj.org/article/33af4f773e164ef482636020595123dd
Autor:
Vera Zywitza, Ejona Rusha, Dmitry Shaposhnikov, Jorge Ruiz-Orera, Narasimha Telugu, Valentyna Rishko, Masafumi Hayashi, Geert Michel, Lars Wittler, Jan Stejskal, Susanne Holtze, Frank Göritz, Robert Hermes, Jichang Wang, Zsuzsanna Izsvák, Silvia Colleoni, Giovanna Lazzari, Cesare Galli, Thomas B. Hildebrandt, Katsuhiko Hayashi, Sebastian Diecke, Micha Drukker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract The northern white rhinoceros (NWR) is probably the earth’s most endangered mammal. To rescue the functionally extinct species, we aim to employ induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro.
Externí odkaz:
https://doaj.org/article/7d2718019bd844b08e9b1dd694becabd
Autor:
Suhail A. Ansari, Widad Dantoft, Jorge Ruiz-Orera, Afzal P. Syed, Susanne Blachut, Sebastiaan van Heesch, Norbert Hübner, Nina Henriette Uhlenhaut
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5622-5638 (2022)
Glucocorticoids such as dexamethasone (Dex) are widely used to treat both acute and chronic inflammatory conditions. They regulate immune responses by dampening cell-mediated immunity in a glucocorticoid receptor (GR)-dependent manner, by suppressing
Externí odkaz:
https://doaj.org/article/c56c0bed9fc4420d97347ba2a7faae0a
Autor:
Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-34 (2021)
Abstract Background Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the efficiency of mRNA translatio
Externí odkaz:
https://doaj.org/article/19d7de0ec8794ef6952216fe9ea71d99
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background A large fraction of genes contains upstream ORFs (uORFs) in the 5′ untranslated region (5’UTR). The translation of uORFs can inhibit the translation of the main coding sequence, for example by causing premature dissociation of
Externí odkaz:
https://doaj.org/article/1dbf988332b042e2a0a5819a04344a3c
Autor:
Friederike Cuello, Anika E Knaust, Umber Saleem, Malte Loos, Janice Raabe, Diogo Mosqueira, Sandra Laufer, Michaela Schweizer, Petra van der Kraak, Frederik Flenner, Bärbel M Ulmer, Ingke Braren, Xiaoke Yin, Konstantinos Theofilatos, Jorge Ruiz‐Orera, Giannino Patone, Birgit Klampe, Thomas Schulze, Angelika Piasecki, Yigal Pinto, Aryan Vink, Norbert Hübner, Sian Harding, Manuel Mayr, Chris Denning, Thomas Eschenhagen, Arne Hansen
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 6, Pp 1-19 (2021)
Abstract The phospholamban (PLN) p.Arg14del mutation causes dilated cardiomyopathy, with the molecular disease mechanisms incompletely understood. Patient dermal fibroblasts were reprogrammed to hiPSC, isogenic controls were established by CRISPR/Cas
Externí odkaz:
https://doaj.org/article/5d37d2b00c544319a7185856d6ba9563
Autor:
William R. Blevins, Jorge Ruiz-Orera, Xavier Messeguer, Bernat Blasco-Moreno, José Luis Villanueva-Cañas, Lorena Espinar, Juana Díez, Lucas B. Carey, M. Mar Albà
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Genome-wide studies of de novo genes have tended to focus on genomic open reading frames (ORFs). Here, Blevins et al. use deep transcriptomics and synteny information to identify de novo transcripts in the yeast Saccharomyces cerevisiae, many of whic
Externí odkaz:
https://doaj.org/article/a21273671edd495a97f282be1951fb46
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Genes express multiple mRNA isoforms through alternative processing. Here the authors analyze ribosome profiling data with ORQAS (ORF quantification pipeline for alternative splicing) and report that 40–50% of the expressed mRNA isoforms are transl
Externí odkaz:
https://doaj.org/article/8300914fcd7944f19456d74ca9806c68
Autor:
Elena Senís, Miriam Esgleas, Sonia Najas, Verónica Jiménez-Sábado, Camilla Bertani, Marta Giménez-Alejandre, Alba Escriche, Jorge Ruiz-Orera, Marta Hergueta-Redondo, Mireia Jiménez, Albert Giralt, Paolo Nuciforo, M. Mar Albà, Héctor Peinado, Daniel del Toro, Leif Hove-Madsen, Magdalena Götz, María Abad
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Long noncoding RNAs (lncRNAs) are regulatory molecules which have been traditionally considered as “non-coding”. Strikingly, recent evidence has demonstrated that many non-coding regions, including lncRNAs, do in fact contain small-open reading f
Externí odkaz:
https://doaj.org/article/3dac13a368e84670974c18ed67fa60c7
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 12, p e1009658 (2021)
RNA-binding proteins (RBPs) can regulate more than a single aspect of RNA metabolism. We searched for such previously undiscovered multifunctionality within a set of 143 RBPs, by defining the predictive value of RBP abundance for the transcription an
Externí odkaz:
https://doaj.org/article/b61cbc0e3a0349e781779516cc0c2d0c