Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jorge Ramirez-Franco"'
Autor:
Jorge Ramirez-Franco, Kévin Debreux, Marion Sangiardi, Maya Belghazi, Yujin Kim, Suk-Ho Lee, Christian Lévêque, Michael Seagar, Oussama El Far
Publikováno v:
Neurobiology of Disease, Vol 196, Iss , Pp 106513- (2024)
In animal models of LGI1-dependent autosomal dominant lateral temporal lobe epilepsy, Kv1 channels are downregulated, suggesting their crucial involvement in epileptogenesis. The molecular basis of Kv1 channel-downregulation in LGI1 knock-out mice ha
Externí odkaz:
https://doaj.org/article/2e7ee02f8fec4a0aa115a578527a6516
Autor:
Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Liss
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-26 (2023)
Abstract Here we present a deep learning-based image analysis platform (DLAP), tailored to autonomously quantify cell numbers, and fluorescence signals within cellular compartments, derived from RNAscope or immunohistochemistry. We utilised DLAP to a
Externí odkaz:
https://doaj.org/article/7e2313ece132485ba389be8ee8efcbe2
Autor:
Johanna Extrémet, Jorge Ramirez-Franco, Laure Fronzaroli-Molinieres, Norah Boumedine-Guignon, Norbert Ankri, Oussama El Far, Juan José Garrido, Dominique Debanne, Michaël Russier
Leucine-rich Glioma Inactivated 1 (LGI1) is a glycoprotein secreted by neurons, the deletion of which leads to Autosomal Dominant Lateral Temporal Lobe Epilepsy. Recently, we showed that LGI1 deficiency in a mouse model (KO-Lgi1) decreased Kv1.1 chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba33a6ddf9b03a12d3a50ed6f7488d04
https://doi.org/10.1101/2023.01.25.525523
https://doi.org/10.1101/2023.01.25.525523
Autor:
Gertrudis Perea, Candela Gonzalez-Arias, Julio Esparza, Cristina Sanchez-Puelles, Lucia Arancibia, Andrea Sanchez-Ruiz, Jorge Ramirez-Franco, Davide Gobbo, Frank Kirchhoff
Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal and synaptic physiology. Astrocytic alterations have been found in Major Depressive Disorder (MDD) patients; however, the consequences of astrocyte Ca2+ signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe6c5c90b1e5c68afefabf2bebb20ae7
https://doi.org/10.21203/rs.3.rs-2361503/v1
https://doi.org/10.21203/rs.3.rs-2361503/v1
Autor:
Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Christina Pötschke, Jean-Marc Goillard, Moritz Münchmeyer, Rosanna Parlato, Birgit Liss
Here we present a deep learning-based image analysis platform (DLAP), tailored to autonomously quantify numbers of neuronal subtypes in defined areas, and of fluorescence signals, derived from RNAscope probes or immunohistochemistry, in defined cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a935d72992fc710e4d3487bb6cc72f
https://doi.org/10.1101/2022.12.14.520432
https://doi.org/10.1101/2022.12.14.520432
Autor:
Jorge Ramirez-Franco, Fodil Azzaz, Marion Sangiardi, Géraldine Ferracci, Fahamoe Youssouf, Michel Robert Popoff, Michael Seagar, Christian Lévêque, Jacques Fantini, Oussama El Far
Publikováno v:
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2022, 79 (9), pp.496. ⟨10.1007/s00018-022-04527-4⟩
Cellular and Molecular Life Sciences, 2022, 79 (9), pp.496. ⟨10.1007/s00018-022-04527-4⟩
International audience; Botulinum neurotoxin serotype B (BoNT/B) uses two separate protein and polysialoglycolipid-binding pockets to interact with synaptotagmin 1/2 and gangliosides. However, an integrated model of BoNT/B bound to its neuronal recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d2f4bb309d656f914aa9f1bcac9eb7
https://pubmed.ncbi.nlm.nih.gov/36006520
https://pubmed.ncbi.nlm.nih.gov/36006520
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1
Autor:
Jorge Ramirez-Franco, Kévin Debreux, Johanna Extremet, Yves Maulet, Maya Belghazi, Claude Villard, Marion Sangiardi, Fahamoe Youssouf, Lara El Far, Christian Lévêque, Claire Debarnot, Pascale Marchot, Sofija Paneva, Dominique Debanne, Michael Russier, Michael Seagar, Sarosh R Irani, Oussama El Far
Publikováno v:
Brain-A Journal of Neurology
Brain-A Journal of Neurology, 2022, pp.awac218. ⟨10.1093/brain/awac218⟩
Brain-A Journal of Neurology, 2022, pp.awac218. ⟨10.1093/brain/awac218⟩
Autoantibodies against leucine-rich glioma-inactivated 1 (LGI1) occur in patients with encephalitis who present with frequent focal seizures and a pattern of amnesia consistent with focal hippocampal damage. To investigate whether the cellular and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47e29bfb73faf39171eae8c48c1bcf2
https://pubmed.ncbi.nlm.nih.gov/35727946
https://pubmed.ncbi.nlm.nih.gov/35727946
Autor:
Jorge Ramirez-Franco, Kévin Debreux, Johanna Extremet, Yves Maulet, Maya Belghazi, Claude Villard, Marion Sangiardi, Fahamoe Youssouf, Lara El Far, Christian Lévêque, Claire Debarnot, Pascale Marchot, Sofija Paneva, Dominique Debanne, Michael Russier, Michael Seagar, Sarosh R Irani, Oussama El Far
Autoantibodies against leucine-rich glioma-inactivated 1 (LGI1) occur in patients with encephalitis who present with frequent focal seizures and a pattern of amnesia consistent with focal hippocampal damage. To investigate whether the cellular and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46b7a577bd302c4ec0743f8baca25c26
https://doi.org/10.1101/2022.03.29.486232
https://doi.org/10.1101/2022.03.29.486232
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
Hippocampal interneurons comprise a diverse family of inhibitory neurons which function is critical for fine information processing. Along with gamma-aminobutyric acid (GABA), interneurons secrete a myriad of neuroactive substances via secretory vesi
Externí odkaz:
https://doaj.org/article/ac26c4ebda1e43b7971a0f5795701975
Autor:
Candela González Arias, Julio Esparza, Cristina Sánchez-Puelles, Lucía Arancibia, Andrea Sánchez-Ruiz, Jorge Ramírez-Franco, Davide Gobbo, Frank Kirchhoff, Gertrudis Perea
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S229- (2023)
Externí odkaz:
https://doaj.org/article/38e5cc333c034da783009ba8a1e74917