Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jorge R. Quesada"'
Autor:
Adan Rios, Theresa W. Fossum, Susan P. Colby-Germinario, Allan L. Goldstein, Dallas W. Anderson, Mark A. Wainberg, Jorge R. Quesada
Publikováno v:
Virus Research. 155:189-194
We demonstrate that a photo-labeled derivative of the non-nucleoside reverse transcriptase inhibitor (NNRTI) dapivirine termed DAPY, when used together with exposure to ultraviolet light, was able to completely and irreversibly inactivate both HIV-1
Autor:
Adan Rios, Jorge R. Quesada, Mark A. Wainberg, Dallas W. Anderson, Allan L. Goldstein, Theresa W. Fossum, Susan P. Colby-Germinario
Publikováno v:
Vaccine. 27:6137-6142
We describe a new method for the development of a preventive inactivated-HIV vaccine, based on photo-inactivation of HIV reverse transcriptase (RT), which preserves both the conformational and functional integrity of viral surface proteins. The RT of
Publikováno v:
Clinical breast cancer. 14(5)
Sarcoidosis is a systemic, granulomatous disorder that affects the lungs and mediastinal lymph nodes in most patients. Areas affected by sarcoidosis can exhibit F-fluoro2-deoxy-D-glucose avidity on positron emission tomography (PET). We report the ca
Autor:
Brandy Shattuck, Luis Marcos, Anas Alrwas, Shivang Mehta, Jorge R. Quesada, Harinder S. Juneja, Nghia D. Nguyen
Publikováno v:
Cancer genetics. 205(10)
We report an unusual case of a symptomatic patient who initially had high hemoglobin and low serum erythropoietin levels, fitting a clinical diagnosis of polycythemia vera. However, after treatment with hydroxyurea and serial phlebotomies had been st
Autor:
Jorge R. Quesada, Robert J. Amato
Publikováno v:
Sarcoma, Vol 2012 (2012)
Sarcoma
Sarcoma
Basic research in sarcoma models has been fundamental in the discovery of scientific milestones leading to a better understanding of the molecular biology of cancer. Yet, clinical research in sarcoma has lagged behind other cancers because of the mul
Publikováno v:
American journal of hematology. 33(3)
The efficacy of interferon alpha in treatment of hairy cell leukemia is well established. Our experience with low doses of 2'-deoxycoformycin, a competitive inhibitor of adenosine deaminase, showed that it was also effective against hairy cell leukem
Publikováno v:
Journal of Clinical Oncology. 3:1086-1092
Partially purified interferon alpha (IFN alpha) was administered to 50 patients with metastatic renal-cell carcinoma (RCC) studied for more than two years. Complete or partial remissions were observed in 26% of the patients. Duration of remissions ra
Autor:
Razelle Kurzrock, Samuel Saks, Barthel Barlogie, Jorge R. Quesada, Raymond Alexanian, Jordan U. Gutterman
Publikováno v:
American Journal of Hematology. 29:1-4
Fifteen patients with multiple myeloma, five with hairy cell leukemia, and five with Waldenstrom's macroglobulinemia were treated with recombinant interferon gamma (rINF-gamma) to determine the antitumor activity of this agent. The rIFN-gamma was adm
Autor:
Samuel G. Murphy, J. U. Gutterman, J. Morgan, Evan M. Hersh, C. R. Gschwind, Jorge R. Quesada
Publikováno v:
JNCI: Journal of the National Cancer Institute. 66:993-1002
The effects of active nonspecific immunotherapy were studied in 42 patients receiving daily iv Corynebacterium parvum at 2 mg/m2 in 14-day courses and in 14 patients receiving iv methanol extraction residue of BCG (MER) at 0.5 mg/m2 weekly. The host
Autor:
J. U. Gutterman, Carl Plager, Robert S. Benjamin, Jorge R. Quesada, Moshe Talpaz, Hagop M. Kantarjian
Publikováno v:
European Journal of Cancer and Clinical Oncology. 22:685-689
Difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, and human leukocyte interferon (IFN-α) have synergistic anti-tumor activities in vivo in B 16 melanoma and in vitro against several human cancer cell lines. We hav