Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53

Autor: Jayanth Kumar Palanichamy, Tiffany M. Tran, Jennifer K. King, Sol Katzman, Alexander J. Ritter, Gunjan Sharma, Christine Tso, Jorge R. Contreras, Thilini R. Fernando, Jeremy R. Sanford, Dinesh S. Rao

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Loss of function in the tumor suppressor gene TP53 is the most common alteration seen in human cancer. In mice, P53 deletion in all cells leads predominantly to the development of T-cell lymphomas, followed by B-cell lymphomas, sarcomas and

Externí odkaz: https://doaj.org/article/d4d856ddeb78490fb274068a06234553

Development of Notch1 Positive T-Lineage Lymphomas or Splenic Marginal Zone Lymphomas with Pan-Hematopoietic or Pro-B Cell Specific Deletion of Trp53 with Distinct Differentially Dysregulated Pathways

Autor: J. King, Thilini Fernando, Tiffany M. Tran, Jayanth Kumar Palanichamy, Jeremy R. Sanford, Christine Tso, Jorge R. Contreras, Sol Katzman, Gunjan Sharma, Dinesh S. Rao

Publikováno v: Blood. 138:2229-2229

Deletion of the tumor suppressor gene TP53 (Trp53 in mice) has been associated with the development of numerous human malignancies. TP53 acts as a central coordinator of the DNA damage response. In mice, pan-Trp53 deletion leads predominantly to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ebeab49609221527f19252c0a5b00ed
https://doi.org/10.1182/blood-2021-150931

The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia

Autor: Cody J. Aros, Dinesh S. Rao, Giuseppe Basso, Jasmine Gajeton, Tiffany M. Tran, David Casero, Ella V. Waters, Martina Pigazzi, Nolan M. Ung, Norma I. Rodriguez-Malave, Jorge R. Contreras, Matteo Zampini, Michael O. Alberti, Jaime Anguiano, Jayanth Kumar Palanichamy, Thilini Fernando

Publikováno v: Molecular cancer, vol 16, iss 1
Molecular Cancer, Vol 16, Iss 1, Pp 1-15 (2017)
Fernando, TR; Contreras, JR; Zampini, M; Rodriguez-Malave, NI; Alberti, MO; Anguiano, J; et al.(2017). The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia. MOLECULAR CANCER, 16. doi: 10.1186/s12943-017-0692-x. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6t81514x
Molecular Cancer

Background Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromosomally adjacent genes. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec9eb9534df36f7c0cb526aa6478b6c
https://escholarship.org/uc/item/6t81514x

Regulation of Marginal Zone B Cell Differentiation By microRNA-146a Via the Numb-Notch Pathway

Autor: Nolan Ung, Thilini Fernando, Michael O. Alberti, Jorge R. Contreras, May Paing, Matteo Pellegrini, Kelvin Xi Zhang, Dinesh S. Rao, Jennifer K. King

Publikováno v: Blood, vol 128, iss 22

B cell development in bone marrow is followed by specification into spleen subsets, including marginal zone (MZ) cells. MZ require elaboration of distinct gene expression programs for development. Given their role in gene regulation, its not surprisi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b13f816aa1d2d79c698fc7006977daf
https://escholarship.org/uc/item/7jb8v6zz

BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia

Autor: Parth C. Patel, Dinesh S. Rao, Jayanth Kumar Palanichamy, Norma I. Rodriguez-Malave, Jaime Anguiano, Kimanh T. Pioli, Tiffany M. Tran, Michael Davoren, Salemiz Sandoval, Thilini Fernando, Jorge R. Contreras, Michael O. Alberti

Publikováno v: Molecular cancer, vol 14, iss 1
Molecular Cancer

Background A new class of non-coding RNAs, known as long non-coding RNAs (lncRNAs), has been recently described. These lncRNAs are implicated to play pivotal roles in various molecular processes, including development and oncogenesis. Gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386607c48388ac772fef56f7263e1af0
https://doi.org/10.1186/s12943-015-0485-z