Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Jorge R Espinosa"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009810 (2022)
Biomolecular condensates formed via liquid-liquid phase separation (LLPS) play a crucial role in the spatiotemporal organization of the cell material. Nucleic acids can act as critical modulators in the stability of these protein condensates. To unve
Externí odkaz:
https://doaj.org/article/48bd1ca6b16048ff94fece7e4cdabdff
Autor:
Kyle Brown, Pin Yu Chew, Steven Ingersoll, Jorge R. Espinosa, Anne Aguirre, Axel Espinoza, Joey Wen, Kalkidan Astatike, Tatiana G. Kutateladze, Rosana Collepardo-Guevara, Xiaojun Ren
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113997- (2024)
Externí odkaz:
https://doaj.org/article/c66fa4fd77ec4f6893dd3fcf44c3f9d3
Autor:
Kyle Brown, Pin Yu Chew, Steven Ingersoll, Jorge R. Espinosa, Anne Aguirre, Axel Espinoza, Joey Wen, Kalkidan Astatike, Tatiana G. Kutateladze, Rosana Collepardo-Guevara, Xiaojun Ren
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113136- (2023)
Summary: Polycomb repressive complex 1 (PRC1) undergoes phase separation to form Polycomb condensates that are multi-component hubs for silencing Polycomb target genes. In this study, we demonstrate that formation and regulation of PRC1 condensates a
Externí odkaz:
https://doaj.org/article/90f4a766e5c946ce863b02c3e0c6d970
Autor:
Samuel Blazquez, Ignacio Sanchez‐Burgos, Jorge Ramirez, Tim Higginbotham, Maria M. Conde, Rosana Collepardo‐Guevara, Andres R. Tejedor, Jorge R. Espinosa
Publikováno v:
Advanced Science, Vol 10, Iss 25, Pp n/a-n/a (2023)
Abstract Maturation of functional liquid‐like biomolecular condensates into solid‐like aggregates has been linked to the onset of several neurodegenerative disorders. Low‐complexity aromatic‐rich kinked segments (LARKS) contained in numerous
Externí odkaz:
https://doaj.org/article/57e039561584474296f51f4b1026f5f3
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Biomolecular condensates formed by the process of liquid–liquid phase separation (LLPS) play diverse roles inside cells, from spatiotemporal compartmentalisation to speeding up chemical reactions. Upon maturation, the liquid-like propertie
Externí odkaz:
https://doaj.org/article/aafa03b5558d431cbc09e88473e012d3
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Biomolecular condensates are liquid-like membraneless compartments that contribute to the spatiotemporal organization of proteins, RNA, and other biomolecules inside cells. Some membraneless compartments, such as nucleoli, are dispersed as d
Externí odkaz:
https://doaj.org/article/521a2f5926d8490f959614a9ad5e2782
Autor:
Georg Krainer, Timothy J. Welsh, Jerelle A. Joseph, Jorge R. Espinosa, Sina Wittmann, Ella de Csilléry, Akshay Sridhar, Zenon Toprakcioglu, Giedre Gudiškytė, Magdalena A. Czekalska, William E. Arter, Jordina Guillén-Boixet, Titus M. Franzmann, Seema Qamar, Peter St George-Hyslop, Anthony A. Hyman, Rosana Collepardo-Guevara, Simon Alberti, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Elucidating the molecular driving forces underlying liquid–liquid phase separation is a key objective for understanding biological function and malfunction. Here the authors show that a wide range of cellular proteins, including FUS, TDP-43, Brd4,
Externí odkaz:
https://doaj.org/article/f1a7c13511ed46d3b7d48b9f4017a81c
Publikováno v:
The Journal of Chemical Physics. 158
One of the most accepted hypothesis to explain the anomalous behavior of water is the presence of a critical point between two liquids, the liquid–liquid critical point (LLCP), buried within the deep supercooled regime. Unfortunately, such hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1237b38eb6832be736b5c6c02b7e333
https://doi.org/10.1063/5.0147345
https://doi.org/10.1063/5.0147345
Publikováno v:
Physical Review Letters. 130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece584e10dc2008e59c9aaffa9516362
https://doi.org/10.1103/physrevlett.130.118001
https://doi.org/10.1103/physrevlett.130.118001
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 278 (2021)
Biomolecular condensates, which assemble via the process of liquid–liquid phase separation (LLPS), are multicomponent compartments found ubiquitously inside cells. Experiments and simulations have shown that biomolecular condensates with many compo
Externí odkaz:
https://doaj.org/article/55325487bd2645b4a66d1149ec393724