Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Jorge PEDROSA"'
Autor:
Bruna Coelho-Ribeiro, Helena G. Silva, Belém Sampaio-Marques, Alexandra G. Fraga, Olga Azevedo, Jorge Pedrosa, Paula Ludovico
Publikováno v:
Cells, Vol 13, Iss 8, p 654 (2024)
Fabry Disease (FD) is one of the most prevalent lysosomal storage disorders, resulting from mutations in the GLA gene located on the X chromosome. This genetic mutation triggers glo-botriaosylceramide (Gb-3) buildup within lysosomes, ultimately impai
Externí odkaz:
https://doaj.org/article/73d525dfbc824cf88540d3c43327ce75
Autor:
André Santa Cruz, Ana Mendes-Frias, Marne Azarias-da-Silva, Sónia André, Ana Isabel Oliveira, Olga Pires, Marta Mendes, Bárbara Oliveira, Marta Braga, Joana Rita Lopes, Rui Domingues, Ricardo Costa, Luís Neves Silva, Ana Rita Matos, Cristina Ângela, Patrício Costa, Alexandre Carvalho, Carlos Capela, Jorge Pedrosa, António Gil Castro, Jérôme Estaquier, Ricardo Silvestre
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Post-acute sequelae SARS-CoV-2 (PASC), also known as long COVID is a chronic and often debilitating condition that develops following acute disease. Here authors show that individuals who suffer from PASC symptoms at six month following infection are
Externí odkaz:
https://doaj.org/article/97055119f2a348ecad17d46b48646719
Autor:
Juan Dominguez, Ana I. Mendes, Ana R. Pacheco, Maria J. Peixoto, Jorge Pedrosa, Alexandra G. Fraga
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Mycobacterium ulcerans causes Buruli Ulcer, a neglected infectious skin disease that typically progresses from an early non-ulcerative lesion to an ulcer with undermined edges. If not promptly treated, these lesions can lead to severe disfigurement a
Externí odkaz:
https://doaj.org/article/680e1049828646daa313268b2d135280
Autor:
Ana Isabel MENDES, Maria João PEIXOTO, Alexandra Pinto MARQUES, Jorge PEDROSA, Alexandra Gabriel FRAGA
Publikováno v:
BMC Research Notes, Vol 15, Iss 1, Pp 1-6 (2022)
Abstract Objective Diabetic foot infection (DFI) represents a major healthcare burden, for which treatment is challenging owing to the pathophysiological alterations intrinsic to diabetes and the alarming increase of antimicrobial resistance. Novel t
Externí odkaz:
https://doaj.org/article/bafb17c55c404682a8938f27fe7c9e94
Autor:
Sonia André, Marne Azarias da Silva, Morgane Picard, Aurélie Alleaume-Buteau, Lucy Kundura, Renaud Cezar, Calaiselvy Soudaramourty, Santa Cruz André, Ana Mendes-Frias, Alexandre Carvalho, Carlos Capela, Jorge Pedrosa, António Gil Castro, Paul Loubet, Albert Sotto, Laurent Muller, Jean-Yves Lefrant, Claire Roger, Pierre-Géraud Claret, Sandra Duvnjak, Tu-Anh Tran, Ouafa Zghidi-Abouzid, Pierre Nioche, Ricardo Silvestre, Pierre Corbeau, Fabrizio Mammano, Jérôme Estaquier
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-15 (2022)
Abstract In addition to an inflammatory reaction, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-infected patients present lymphopenia, which we recently reported as being related to abnormal programmed cell death. As an efficient humor
Externí odkaz:
https://doaj.org/article/6fecc8e6b5164568af51fbebea43c83e
Autor:
Ana Isabel Mendes, Alexandra Gabriel Fraga, Maria João Peixoto, Ivo Aroso, Adhemar Longatto‐Filho, Alexandra Pinto Marques, Jorge Pedrosa
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 3, Pp n/a-n/a (2023)
Abstract Diabetic foot infection (DFI) is an important cause of morbidity and mortality. Antibiotics are fundamental for treating DFI, although bacterial biofilm formation and associated pathophysiology can reduce their effectiveness. Additionally, a
Externí odkaz:
https://doaj.org/article/2c0589e18f2f43a7a28ba37d44b7967e
Autor:
João Fevereiro, Alexandra G. Fraga, Carlos Capela, Ghislain E. Sopoh, Ange Dossou, Gilbert Adjimon Ayelo, Maria João Peixoto, Cristina Cunha, Agostinho Carvalho, Fernando Rodrigues, Jorge Pedrosa
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 223-225 (2021)
Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the BCL2L11 gene). We here report the association of genetic
Externí odkaz:
https://doaj.org/article/6d2620f8d87b431d8320aa267635c625
Autor:
André Santa Cruz, Ana Mendes-Frias, Ana Isabel Oliveira, Luís Dias, Ana Rita Matos, Alexandre Carvalho, Carlos Capela, Jorge Pedrosa, António Gil Castro, Ricardo Silvestre
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Hyper-inflammatory responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are a major cause of disease severity and death. Predictive prognosis biomarkers to guide therapeutics are critically lacking. Several studies have i
Externí odkaz:
https://doaj.org/article/0223a3c94ee14347be73d2379c0df7c6
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008161 (2020)
BACKGROUND:Buruli ulcer (BU) is a necrotizing skin disease, caused by Mycobacterium ulcerans, with poorly understood acquisition risk factors. This review aims at evaluating the importance of individual-sex, age, family ties with history of BU, gene
Externí odkaz:
https://doaj.org/article/d36ab920bcfd4a93be8596abf472f372
Autor:
Alexandra G Fraga, Gabriela Trigo, Ramya K Murthy, Shamim Akhtar, Madhavi Hebbur, Ana Rita Pacheco, Juan Dominguez, Rita Silva-Gomes, Carine M Gonçalves, Hugo Oliveira, António G Castro, Umender Sharma, Joana Azeredo, Jorge Pedrosa
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007113 (2019)
Buruli Ulcer (BU) is a cutaneous disease caused by Mycobacterium ulcerans. The pathogenesis of this disease is closely related to the secretion of the toxin mycolactone that induces extensive destruction of the skin and soft tissues. Currently, there
Externí odkaz:
https://doaj.org/article/be335171665840bbb480559a2a6a4957