Výsledky vyhledávání - "Jorge Ochoa-Garay"

Characterization of TCR-induced phosphorylation of PKCθ in primary murine lymphocytes

Autor: Sabine Thébault, Jorge Ochoa-Garay

Publikováno v: Molecular Immunology. 40:931-942

Protein kinase C theta (PKCtheta) is a member of the "novel" PKC subfamily which plays a critical role in T-cell activation. Following T-cell stimulation, PKCtheta translocates to the center of the immunological synapse where it co-localizes with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc70dc75bcce779de71c58d3e898256
https://doi.org/10.1016/j.molimm.2003.10.014

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Nuclear Factor κB Is Required for Peptide Antigen-Induced Differentiation of a CD4+CD8+ Thymocyte Line

Autor: Jorge Ochoa-Garay, Jonathan Kaye, John E. Coligan

Publikováno v: The Journal of Immunology. 160:3835-3843

NF-κB transcription factors are known to regulate the expression of a number of genes involved in T cell activation and function. Some evidence has suggested that they also play a role in T cell development. However, the role of NF-κB in Ag-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92593e096ef8bca9d451d979a6d41c4c
https://doi.org/10.4049/jimmunol.160.8.3835

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The ability of peptides to induce cytotoxic T cells in vitro does not strongly correlate with their affinity for the H-2Ld molecule: implications for vaccine design and immunotherapy

Autor: Harold Kochounian, Jorge Ochoa-Garay, Denise M. McKinney, Minnie McMillan

Publikováno v: Molecular immunology. 34(3)

The hypothesis that the ability of a peptide to bind to a class I molecule correlates with its immunogenicity is controversial. In this paper we have measured the affinity constants of nine synthetic peptides, which have been previously identified as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ef50047b362b2bfdda63ecf4b857ec
https://pubmed.ncbi.nlm.nih.gov/9224969

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H-2Ld-alloreactive T cell hybridomas utilize diverse V alpha and V beta T cell receptor chains

Autor: Denise M. McKinney, Minnie McMillan, Jorge Ochoa-Garay, Katherine A. Louie, Pei-Jia Chen, Susan Groshen

Publikováno v: Molecular immunology. 33(9)

We have sequenced the TCRs from Ld-specific alloreactive T cell hybridomas, whose reactivities we have found to be quite representative of those of a primary dm2 anti-BALB/cJ mixed lymphocyte reaction. We find V beta 6, V beta 7, V beta 8 and V beta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe0ab690742159373a040c72824e005
https://pubmed.ncbi.nlm.nih.gov/8811070

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