Výsledky vyhledávání - "Jorge Monteon"

Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs

Publikováno v: Mol Pharm

Conventional antibody–drug conjugates (ADCs) are heterogeneous mixtures of chemically distinct molecules that vary in both drugs/antibody (DAR) and conjugation sites. Suboptimal properties of heterogeneous ADCs have led to new site-specific conjuga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d883318e923b6b79e4a53f04cf24bb2c
https://doi.org/10.1021/acs.molpharmaceut.5b00432

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Abstract 3826: GITRL-Fc biomarker and mechanism study: GITRL-Fc reduces Treg frequency in tumors and requires effector function for inhibition of tumor growth

Autor: Ming-Hong Xie, Fumiko Takada Axelrod, Belinda Cancilla, Ann M. Kapoun, Reyhaneh Lahmy, Alayne Brunner, Jorge Monteon, Gilbert O'Young, Rose Harris, Pete Yeung, Austin L. Gurney, Andrew Lam, Fiore Cattaruzza, Earth Light Lowe, Gretchen Argast, Jennifer Elechko, Min Wang, Erwan Le Scolan

Publikováno v: Cancer Research. 78:3826-3826

Activation of the co-stimulatory receptor GITR (Glucocorticoid-Induced Tumor Necrosis Factor Receptor) by GITR-Ligand (GITRL) promotes proliferation and activation of effector T cells (T eff) and inhibits suppressive activity of regulatory T cells (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e4558506ad0516bff1035a66dcf6c42
https://doi.org/10.1158/1538-7445.am2018-3826

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Abstract 5627: Anti-TIGIT biomarker study: Inhibition of TIGIT induces loss of Tregs from tumors and requires effector function for tumor growth inhibition

Autor: Fumiko Takada Axelrod, Rose Harris, Austin L. Gurney, Ming-Hong Xie, Pete Yeung, Ann M. Kapoun, Alayne Brunner, Reyhaneh Lahmy, Fiore Cattaruzza, Erwan Le Scolan, John Lewicki, Gilbert O'Young, Jorge Monteon, Andrew Lam, Belinda Cancilla, Min Wang, Earth Light Lowe, Gretchen Argast, Jennifer Elechko

Publikováno v: Cancer Research. 78:5627-5627

The immune checkpoint co-inhibitory receptor TIGIT (T cell immunoreceptor with Ig ITIM domain) is expressed on regulatory T cells (Tregs) and on activated CD4+ T, CD8+ T, and NK cells. We have reported that by blocking TIGIT activity with an IgG2a an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfe5af48895484af23edb76406e7bfd4
https://doi.org/10.1158/1538-7445.am2018-5627

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Abstract 2612: Anti-Tigit induces T cell mediated anti-tumor immune response and combines with immune checkpoint inhibitors to enhance strong and long term anti-tumor immunity

Autor: Hyun-Bae Jie, Fumiko Takada Axelrod, Andrew Lam, Austin L. Gurney, Yu-Wang Liu, Janice Yu, Ming-Hong Xie, Jorge Monteon, John Lewicki, Rui Yun, May Ji, Tim Hoey, Minu K. Srivastava, Erin Mayes, Angie Inkyung Park

Publikováno v: Cancer Research. 77:2612-2612

TIGIT (T cell immunoreceptor with Ig and ITIM domains) has been recently described as an inhibitory receptor which blocks CD8 T cell-mediated anti-tumor immune responses. We have generated an anti-mouse TIGIT antibody (313R12) to evaluate drug effica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8ccacafd479586b5b625069b0f6d422
https://doi.org/10.1158/1538-7445.am2017-2612

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Abstract 2003: Antibody against TIGIT (T cell immunoreceptor with Ig and ITIM domains) induces anti-tumor immune response and generates long-term immune memory

Autor: Angie Inkyung Park, Christopher Murriel, Minu K. Srivastava, Erin Mayes, Austin L. Gurney, Rui Yun, May Ji, Fumiko Takada Axelrod, Ming-Hong Xie, Jorge Monteon, Hyun-Bae Jie, John Lewicki, Tim Hoey, Andrew Lam

Publikováno v: Cancer Research. 77:2003-2003

T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a co-inhibitory molecule containing an immunoreceptor tyrosine-based inhibition motif (ITIM) within its cytoplasmic tail, and is highly expressed on regulatory T cells and activated CD4+ T, CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18dba3bd65ffea064828cc69859d238b
https://doi.org/10.1158/1538-7445.am2017-2003

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Abstract 2214: GITR ligand fusion protein (GITRL-Fc) induces T cell mediated anti-tumor immune response and can combine with anti-PDL1 to enhance anti-tumor immunity and long-term immune memory

Autor: Hyun-Bae Jie, Fumiko Takada Axelrod, Austin L. Gurney, John Lewicki, Tim Hoey, Angie Inkyung Park, Jorge Monteon, Rui Yun, Minu K. Srivastava, Erin Mayes, Ming-Hong Xie

Publikováno v: Cancer Research. 76:2214-2214

GITRL (Glucocorticoid-Induced Tumor Necrosis Factor Receptor Ligand, TNFSF18) is a member of the TNF superfamily and naturally exists as a membrane-anchored type II protein that self assembles as a trimer. GITRL activates the co-stimulatory receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c8b968b61f12f0969214b1b73219352
https://doi.org/10.1158/1538-7445.am2016-2214

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Abstract 3215: GITRL-Fc can significantly reduce tumor growth by stimulating innate and adaptive immunity

Autor: Hyun-Bae Jie, Jorge Monteon, Minu K. Srivastava, Erin Mayes, Austin L. Gurney, Angie Inkyung Park, Rui Yun, Fumiko Takada Axelrod

Publikováno v: Cancer Research. 76:3215-3215

Although the interaction between GITR (Glucocorticoid-Induced Tumor Necrosis Factor Receptor) and GITRL (its ligand) is important for the development of immune responses, the cellular mechanisms underlying anti-tumor immunity including both innate an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5707bb3ea76e89cbc1c72d93f37c0c94
https://doi.org/10.1158/1538-7445.am2016-3215

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Abstract A058: GITRL-Fc, an immunotherapeutic agent that stimulates T-cell-mediated antitumor immune response

Autor: Fumiko Takada Axelrod, Jorge Monteon, Minu K. Srivastava, Austin L. Gurney, Hyun-Bae Jie, Park Inkyung, Erin Mayes, Rui Yun

Publikováno v: Cancer Immunology Research. 4:A058-A058

GITRL, (Glucocorticoid-Induced Tumor Necrosis Factor Receptor Ligand, TNFSF18) is a member of the TNF family of ligands and naturally exists as a membrane-anchored type II protein that self assembles as a trimer. GITRL activates the co-stimulatory re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0abe07ee48cca75b2719123b62c4b8f
https://doi.org/10.1158/2326-6074.cricimteatiaacr15-a058

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