Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jorge Martínez‐Torrecuadrada"'
Autor:
Leire Bejarano, Giuseppe Bosso, Jessica Louzame, Rosa Serrano, Elena Gómez‐Casero, Jorge Martínez‐Torrecuadrada, Sonia Martínez, Carmen Blanco‐Aparicio, Joaquín Pastor, Maria A Blasco
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 7, Pp 1-21 (2019)
Abstract Telomeres are considered as universal anti‐cancer targets, as telomere maintenance is essential to sustain indefinite cancer growth. Mutations in telomerase, the enzyme that maintains telomeres, are among the most frequently found in cance
Externí odkaz:
https://doaj.org/article/9779bb57d13c41769aa864bea9220f33
Autor:
Marta Compte, Seandean L. Harwood, Jorge Martínez-Torrecuadrada, Gema Perez-Chacon, Patricia González-García, Antonio Tapia-Galisteo, Paul M. P. Van Bergen en Henegouwen, Aránzazu Sánchez, Isabel Fabregat, Laura Sanz, Juan M. Zapata, Luis Alvarez-Vallina
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Agonistic monoclonal antibodies (mAbs) targeting the co-stimulatory receptor 4-1BB are among the most effective immunotherapeutic agents across pre-clinical cancer models. However, clinical development of full-length 4-1BB agonistic mAbs, has been ha
Externí odkaz:
https://doaj.org/article/73fed565702c4bd49e60af922d155683
Autor:
Marta Compte, Seandean Lykke Harwood, Ines G. Muñoz, Rocio Navarro, Manuela Zonca, Gema Perez-Chacon, Ainhoa Erce-Llamazares, Nekane Merino, Antonio Tapia-Galisteo, Angel M. Cuesta, Kasper Mikkelsen, Eduardo Caleiras, Natalia Nuñez-Prado, M. Angela Aznar, Simon Lykkemark, Jorge Martínez-Torrecuadrada, Ignacio Melero, Francisco J. Blanco, Jorge Bernardino de la Serna, Juan M. Zapata, Laura Sanz, Luis Alvarez-Vallina
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Cancer therapy using systemically administrated 4-1BB-targeting antibodies is often associated with severe toxicity due to the nonspecific activation of autoreactive T cells. Here, the authors have developed a trimeric antibody targeting both 4-1BB a
Externí odkaz:
https://doaj.org/article/7575acc4586f44568954b0510de1f6d3
Autor:
Marinela Méndez-Pertuz, Paula Martínez, Carmen Blanco-Aparicio, Elena Gómez-Casero, Ana Belen García, Jorge Martínez-Torrecuadrada, Marta Palafox, Javier Cortés, Violeta Serra, Joaquin Pastor, Maria A. Blasco
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Regulation of telomeres and the insulin/PI3K pathway both have roles in aging and cancer development but have not been functionally linked. Here the authors demonstrate that PI3K, via downstream targets, regulates TRF1 via phosphorylation.
Externí odkaz:
https://doaj.org/article/2d614c1112c2497aaf67ea663b43f2d5
Autor:
Sara García-Alonso, Pablo Mesa, Laura de la Puente Ovejero, Gonzalo Aizpurua, Carmen G. Lechuga, Eduardo Zarzuela, Clara M. Santiveri, Manuel Sanclemente, Javier Muñoz, Mónica Musteanu, Ramón Campos-Olivas, Jorge Martínez-Torrecuadrada, Mariano Barbacid, Guillermo Montoya
RAF kinases are RAS-activated enzymes that initiate signalling through the MAPK cascade to control cellular proliferation, differentiation, and survival. Here, we describe the structure of the full-length RAF1 protein in complex with HSP90 and CDC37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf457133a379e3f5fffda757e6ab2530
https://doi.org/10.1101/2022.05.04.490607
https://doi.org/10.1101/2022.05.04.490607
Autor:
Benjamin Krusche, Cristina Ottone, Melanie P Clements, Ewan R Johnstone, Katrin Goetsch, Huang Lieven, Silvia G Mota, Poonam Singh, Sanjay Khadayate, Azhaar Ashraf, Timothy Davies, Steven M Pollard, Vincenzo De Paola, Federico Roncaroli, Jorge Martinez-Torrecuadrada, Paul Bertone, Simona Parrinello
Publikováno v:
eLife, Vol 5 (2016)
Glioblastomas (GBM) are aggressive and therapy-resistant brain tumours, which contain a subpopulation of tumour-propagating glioblastoma stem-like cells (GSC) thought to drive progression and recurrence. Diffuse invasion of the brain parenchyma, incl
Externí odkaz:
https://doaj.org/article/99e030f6989e4de2bac103b0da9fd5ea