Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Jorge M.A. Oliveira"'
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Akademický článek
Mitochondrial dynamics and quality control in Huntington's disease
Autor: Pedro Guedes-Dias, Brígida R. Pinho, Tânia R. Soares, João de Proença, Michael R. Duchen, Jorge M.A. Oliveira
Publikováno v: Neurobiology of Disease, Vol 90, Iss , Pp 51-57 (2016)
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by polyglutamine expansion mutations in the huntingtin protein. Despite its ubiquitous distribution, expression of mutant huntingtin (mHtt) is particularly detrimental to med
Externí odkaz: https://doaj.org/article/ab13d0a22963488ca1ff9ff1f22c587f
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4
Disruptions of circadian rhythms, sleep, and stress responses in zebrafish: New infrared-based activity monitoring assays for toxicity assessment
Autor: Rui F.O. Silva, Brígida R. Pinho, Miguel M. Santos, Jorge M.A. Oliveira
Publikováno v: Chemosphere. 305
Behavioural disruptions are sensitive indicators of alterations to normal animal physiology and can be used for toxicity assessment. The small vertebrate zebrafish is a leading model organism for toxicological studies. The ability to continuously mon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b6a541fd2e2d3f090ca91cba83aa25
https://pubmed.ncbi.nlm.nih.gov/35750227
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5
Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation
Autor: Liliana M Almeida, Michael R. Duchen, Jorge M.A. Oliveira, Brígida R. Pinho
Publikováno v: Life Sciences. 285:120009
Aims Huntington's disease (HD) is caused by a mutant huntingtin protein that misfolds, yields toxic N-terminal fragments, aggregates, and disrupts proteostasis. The Hsp70 chaperone is a potential therapeutic target as it prevents proteotoxicity by fa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9eade53c39888f164a91c1ec7a9256a
https://doi.org/10.1016/j.lfs.2021.120009
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6
The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice
Autor: Ana I. Duarte, Paula I. Moreira, Brígida R. Pinho, Paula M. Canas, Jorge M.A. Oliveira, Michael P. Murphy
Publikováno v: Free Radical Biology & Medicine
Abnormal protein homeostasis (proteostasis), dysfunctional mitochondria, and aberrant redox signalling are often associated in neurodegenerative disorders, such as Huntington's (HD), Alzheimer's and Parkinson's diseases. It remains incompletely under
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85870a24e4f74069ffd8b43a7a0a2113
https://pubmed.ncbi.nlm.nih.gov/31751762
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7
Does the antidepressant sertraline show chronic effects on aquatic invertebrates at environmentally relevant concentrations? A case study with the keystone amphipod, Gammarus locusta
Autor: Jorge M.A. Oliveira, Miguel M. Santos, Teresa Neuparth, Ana Isabel Lopes, Nélson Alves
Publikováno v: Ecotoxicology and environmental safety. 183
The increasing use of Sertraline (SER) as antidepressant and its consequent presence in the aquatic environment is raising concern about the chronic effects of this pharmaceutical to aquatic organisms. As the current concentrations of SER in surface
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57886f7c5fa6ef3636d3f87dbde039f8
https://pubmed.ncbi.nlm.nih.gov/31377518
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8
Mitochondrial dynamics and quality control in Huntington's disease
Autor: Michael R. Duchen, Brígida R. Pinho, Tânia Soares, Pedro Guedes-Dias, João de Proença, Jorge M.A. Oliveira
Publikováno v: Neurobiology of Disease, Vol 90, Iss, Pp 51-57 (2016)
Neurobiology of Disease
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by polyglutamine expansion mutations in the huntingtin protein. Despite its ubiquitous distribution, expression of mutant huntingtin (mHtt) is particularly detrimental to med
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69805bf99747c0399c710df766c3032
http://www.sciencedirect.com/science/article/pii/S0969996115300553
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9
A39 Triad of neuronal vulnerability in huntington’s disease: huntingtin proteostasis, inclusion body formation and mitochondrial function
Autor: Michael R. Duchen, Brígida R. Pinho, Jorge M.A. Oliveira, Tânia Soares
Publikováno v: Pathogenic mechanisms.
Introduction The preferential vulnerability of striatal medium spiny neurons is a pathological hallmark in Huntington’s Disease (HD). Striatal neurons have been proposed to differ from other less vulnerable neuronal populations, namely in their pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f998172bef08ad450d6304d9cfb23250
https://doi.org/10.1136/jnnp-2018-ehdn.37
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10
A19 Pharmacological modulation of HSP70 in cellular models of huntington’s disease
Autor: Liliana M Almeida, Jorge M.A. Oliveira, Sara D. Reis, Brígida R. Pinho
Publikováno v: Pathogenic mechanisms.
Background Huntington’s disease (HD) is a protein misfolding disorder involving a mutant form of the huntingtin protein (Htt) with a polyglutamine expansion. Heat shock proteins (Hsp) are key therapeutic targets in protein misfolding diseases given
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cf6a758708d2f82d63afc33167c7080
https://doi.org/10.1136/jnnp-2018-ehdn.18
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