Zygote cryobanking applied to CRISPR/Cas9 microinjection in mice.

Autor: Geraldine Schlapp, María Noel Meikle, Jorge Luis Pórfido, Alejo Menchaca, Martina Crispo

Publikováno v: PLoS ONE, Vol 19, Iss 7, p e0306617 (2024)

Microinjection of CRISPR/Cas9 requires the availability of zygotes that implies animal breeding, superovulation schemes, and embryo collection. Vitrification of zygotes may allow having ready-to-use embryos and to temporally dissociate the workload o

Externí odkaz: https://doaj.org/article/14371d1cef5846cfa06b718793577cba

Ivermectin reduces coronavirus infection in vivo: a mouse experimental model

Autor: Ana Paula Arévalo, Belen Varela, Romina Pagotto, Maite Duhalde Vega, Marcelo Hill, Mariela Bollati-Fogolín, Hellen Daghero, Jorge Luis Pórfido, Kanji Yamasaki, José Manuel Verdes, Martina Crispo, Mercedes Segovia

SARS-CoV2 is a single strand RNA virus member of the type 2 coronavirus family, responsible for causing COVID-19 disease in humans. The objective of this study was to test the ivermectin drug in a murine model of coronavirus infection using a type 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a55fe53702ef48ae37bd71f175832f2
https://doi.org/10.1101/2020.11.02.363242

Application of target repositioning and in silico screening to exploit fatty acid binding proteins (FABPs) from Echinococcus multilocularis as possible drug targets

Autor: Alan Talevi, Jorge Luis Pórfido, Julián Alberto Bélgamo, Gisela Raquel Franchini, Lucas Nicolás Alberca, Santiago Rodríguez, Franco Nahuel Caram Romero, Betina Córsico

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Fatty acid binding proteins (FABPs) are small intracellular proteins that reversibly bind fatty acids and other hydrophobic ligands. In cestodes, due to their inability to synthesise fatty acids and cholesterol de novo, FABPs, together with other lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65318f41fcc4059aba3f468e5c94396
http://sedici.unlp.edu.ar/handle/10915/136766

Direct interaction between EgFABP1, a fatty acid binding protein from Echinococcus granulosus, and phospholipid membranes

Autor: Valeria Silva, Jorge Luis Pórfido, Gabriela Alvite, Betina Córsico, Malcolm W. Kennedy, Adriana Esteves

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 11, p e1893 (2012)
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Neglected Tropical Diseases

Background: Growth and maintenance of hydatid cysts produced by Echinococcus granulosus have a high requirement for host lipids for biosynthetic processes, membrane building and possibly cellular and developmental signalling. This requires a high deg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96aad4e5dc378d710669f4956b56e22c
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166848/?tool=EBI