Výsledky vyhledávání - "Jorge Luis Maria Ruiz"

Dissertation/ Thesis

Caracterização de uma nanopartícula lipídica semelhante à LDL (LDE) como vetor para RNA de interferência

Autor: Jorge Luis Maria Ruiz

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

As nanopartículas são consideradas promissores vetores para a liberação eficaz e segura de ácidos nucléicos para tipos específicos de célula ou tecido, proporcionando uma alternativa aos vetores virais para terapia gênica. No entanto, com a

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/5/5167/tde-14062011-154226/

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Traditional and Advanced Cell Cultures in Hematopoietic Stem Cell Studies

Autor: Marluce da Cunha Mantovani, Sérgio Paulo Bydlowski, Jorge Luis Maria Ruiz, Debora Levy, Antonio Carlos Ribeiro-Filho

Publikováno v: Cells

Hematopoiesis is the main function of bone marrow. Human hematopoietic stem and progenitor cells reside in the bone marrow microenvironment, making it a hotspot for the development of hematopoietic diseases. Numerous alterations that correspond to di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363e3ae70562a0681f1017da6b025222
https://pubmed.ncbi.nlm.nih.gov/31842488

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Medical applications of clustered regularly interspaced short palindromic repeats (CRISPR/Cas) tool: A comprehensive overview

Autor: Michelli Ramires Teixeira, Thatiana Correa de Melo, Diego Grando Módolo, Edislane Barreiros de Souza, Rodrigo Pinheiro Araldi, Luis G. V. Fernandes, Charbel Khalil, Jorge Luis Maria Ruiz, Pedro Henrique Grignet

Publikováno v: Gene. 745:144636

Since the discovery of the double helix and the introduction of genetic engineering, the possibility to develop new strategies to manipulate the genome has fascinated scientists around the world. Currently scientists have the knowledge andabilitytoed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28efc237ee893e4ae68bb20f51cccc0
https://doi.org/10.1016/j.gene.2020.144636

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Oxysterols selectively promote short-term apoptosis in tumor cell lines

Autor: Maíra Luísa Fidelis, Jorge Luis Maria Ruiz, Alessandro Rodrigues, Debora Levy, Sérgio Paulo Bydlowski, Thatiana Correa de Melo, Bianca Yumi Ohira

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Oxysterols are 27-carbon oxidation products of cholesterol metabolism. Oxysterols possess several biological actions, including the promotion of cell death. Here, we examined the ability of several oxysterols to induce short-term death in cancerous (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da52d793a6ffdb4cca9b284d2244eff

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Oxysterols and mesenchymal stem cell biology

Autor: Thatiana Correa de Melo, Jorge Luis Maria Ruiz, Debora Levy, Sérgio Paulo Bydlowski

Publikováno v: Chemistry and physics of lipids. 207

Oxysterols are oxidized products of cholesterol that play several roles in various pathophysiological processes, including the control of lipid metabolism, immunological processes, and cytotoxicity. Mesenchymal stem cells are multipotent cells with p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb97188d438562bdad2a5c6e9e07152c
https://pubmed.ncbi.nlm.nih.gov/28669640

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Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death

Autor: Alessandro Rodrigues, Debora Levy, Jorge Luis Maria Ruiz, Cesar Isaac, Suelen Feitoza Silva, Sergio Paulo Bydlowski, Maíra Luísa Fidelis, Thatiana Correa de Melo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Mesenchymal stem cells (MSCs) are multipotent cells characterized by self-renewal and cellular differentiation capabilities. Oxysterols comprise a very heterogeneous group derived from cholesterol through enzymatic and non-enzymatic oxidation. Potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05916ff68190ce09eecdd85b887c20f

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Presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the Brazilian population

Autor: E.R.M. Bertoldi, Juliana Pereira, Debora Levy, Sérgio Paulo Bydlowski, Jorge Luis Maria Ruiz

Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 50, Iss 7
Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research, Volume: 50, Issue: 7, Article number: e6172, Published: 05 JUN 2017
Brazilian Journal of Medical and Biological Research v.50 n.7 2017
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC

Several groups have demonstrated that healthy individuals can present the t(14;18) translocation. In this report, the presence of the translocation was examined in healthy blood donors in Brazil, a country considered an ethnic melting pot. The transl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437380f2e05b86064ef3dc8af0a86aa0
https://doi.org/10.1590/1414-431x20176172

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Azidothymidine is Effective Against Human Multiple Myeloma: A New Use for an Old Drug?

Autor: Dalton de Alencar Fischer Chamone, Kleber A. Ferreira, Juliana Pereira, Abrahão Elias Hallack Neto, Graciela Aparecida Brocardo, Renata de Oliveira Costa, Jorge Luis Maria Ruiz, Rodrigo G. Queiroz, Debora Levy, Durvanei Augusto Maria, Sérgio Paulo Bydlowski

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Azidothymidine (AZT) is an antiretroviral drug that affects cell proliferation, apoptosis, and the NF-κB pathway. As multiple myeloma (MM) presents with constitutive activation of NF-κB, we analyzed the effect of AZT on human MM cell lines. We eval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e57c630b94ae021fb038f56967edea1
https://doi.org/10.2174/1871520611307010186

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Improving the Processability of Conductive Polymers: The Case of Polyaniline

Autor: Jorge Luis Maria Ruiz, José Luis Vilas, J. R. Dios, B. Gonzalo, José Manuel Laza, Luis Manuel León

Publikováno v: Advances in Polymer Technology. 32:E180-E188

Polyaniline (PANI) is one of the most widely used conductive polymers because of its ease of synthesis in addition to its good electrical properties. However, the difficulty in its processability limits its potential applications. In this work, condu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c40737b0d365a699d02a23332037bba6
https://doi.org/10.1002/adv.21261

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Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation

Autor: Avelino Corma, P. Botella, Jorge Luis Maria Ruiz, Sonia Miranda, Carlos Muniesa, Ibane Abasolo, Manuel Quesada, Simó Schwartz, Yolanda Fernández

Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname

[EN] Here we report the design, synthesis and biological evaluation of surface-modified silica nanoparticles (SNP) for the delivery of camptothecin (CPT). Drug has been covalently linked to the nanoparticle through an ester bond with the 20-hydroxy m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf3d1d60ce257e220f4f4125062c5c3
https://doi.org/10.1016/j.jconrel.2011.06.039

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