Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jorge L.O. Domingos"'
Autor:
Talita de A. Fernandes, Jorge L.O. Domingos, Carmen Nájera, Paulo R. R. Costa, José M. Sansano, Luana G. de Souza, Magdalena N. Rennó
Publikováno v:
RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)
Universidad de Alicante (UA)
The enantioselective electrophilic fluorination of α-aryl-tetralones is promoted by cinchonine/selectfluor combinations. This strategy allows a facile synthesis of the corresponding 2-fluoro-2-aryl-1-tetralones with excellent yields (up to >98%) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549970d2c3e1c986015fe0ec98993760
https://doi.org/10.1016/j.jfluchem.2018.11.007
https://doi.org/10.1016/j.jfluchem.2018.11.007
Autor:
Juliana de O. C. Brum, Paulo R. R. Costa, Jorge L.O. Domingos, Angela T. Costa, Guilherme S. Caleffi
Publikováno v:
The Journal of organic chemistry. 86(6)
3-Arylidenechroman-4-ones and 2-arylidene-1-tetralones are hydrogenated to cis-benzylic alcohols in dr's and er's up to 99:1 via a C═C and C═O one-pot reduction in the presence of 2-5 mol % Noyori-Ikariya-type RuII chiral complexes and HCO2Na as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5d6b8c40822cd88b383033d22c4560
https://pubmed.ncbi.nlm.nih.gov/33683900
https://pubmed.ncbi.nlm.nih.gov/33683900
Autor:
Samuel Monteiro, Carlos Roberto Koscky Paier, Paulo R. R. Costa, Julio C. F. Barcellos, Francisco V. Gaspar, Cláudia Pessoa, Maria Claudia dos Santos Luciano, Jorge L.O. Domingos, Soraya Marques Ribeiro
Publikováno v:
Bioorganic chemistry. 107
Natural pterocarpans and synthetic 5-carba-pterocarpans are isosteres in which the oxygen atom at position 5 in the pyran-ring of pterocarpans is replaced by a methylene group. These 5-carba-analogues were obtained in good yields through the palladiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdba6863b3e57c8ec6abffdce8df6c40
https://pubmed.ncbi.nlm.nih.gov/33453646
https://pubmed.ncbi.nlm.nih.gov/33453646
Autor:
Karen Machado Gomes, Jorge L.O. Domingos, Claudia Alessandra Fortes Aiub, Carmen Penido, Israel Felzenszwalb, Mariana Marques Costa-Lima, Evanoel Crizanto de Lima, Nubia Boechat, Angelo C. Pinto, Thadeu Estevam Moreira Maramaldo Costa, Maria das Graças M. O. Henriques, Maria C.S. Lourenço, Frederico Silva Castelo-Branco, Carlos Fernando Araujo-Lima
Publikováno v:
European Journal of Medicinal Chemistry. 146:529-540
Tuberculosis (TB) is one of the leading causes of death worldwide. The emergence of multi-drug resistant strains of Mycobacterium tuberculosis (Mtb) and TB-HIV co-infection are major public health challenges. The anti-TB drugs of first choice were de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6a9a245fe79f443b683a623a7e8012
https://doi.org/10.1016/j.ejmech.2018.01.071
https://doi.org/10.1016/j.ejmech.2018.01.071
Publikováno v:
SynOpen, Vol 01, Iss 01, Pp 0091-0096 (2017)
α-Aryl malonate and α-aryl cyano acetate moieties are found in the structures of many bioactive compounds. They are also key intermediates for the synthesis of many compounds such as isoflavonoids. In this work, we synthesized these compounds, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6765ee351ef4d5700fc6852c0123fc18
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1588550
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1588550
Autor:
Jorge L.O. Domingos, Nubia Boechat, Cheyene Almeida Celestino Menozzi, Rodolfo Rodrigo Florido França, Frederico Silva Castelo Branco
Publikováno v:
Revista Virtual de Química. 9:1216-1234
O fluconazol e um antifungico da classe dos azois de segunda geracao, sendo integrante da Relacao Nacional de Medicamentos Essenciais (RENAME) do Ministerio da Saude do Brasil. Este farmaco e considerado como de primeira escolha para o tratamento de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::903e20bf8c9debd38013cfead591d753
https://doi.org/10.21577/1984-6835.20170071
https://doi.org/10.21577/1984-6835.20170071
Autor:
Eduardo J. Salustiano, Angela T. Costa, Paulo R. R. Costa, Vivian M. Rumjanek, Jorge L.O. Domingos, Luana G. de Souza, Kelli Monteiro da Costa, Magdalena N. Rennó
Publikováno v:
Bioorganic Chemistry. 110:104790
α-aryl-α-tetralones and α-fluoro-α-aryl-α-tetralones derivatives were synthesized by palladium catalyzed α-arylation reaction of α-tetralones and α-fluoro-α-tetralones, with bromoarenes in moderate to good yields. These compounds were evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61a9f31219c73f8e930c52ae91f7b0b
https://doi.org/10.1016/j.bioorg.2021.104790
https://doi.org/10.1016/j.bioorg.2021.104790
Autor:
Paulo R. R. Costa, Talita de A. Fernandes, Dinesh Manvar, Amartya Basu, Jorge L.O. Domingos, Daniel Brian Nichols, Neerja Kaushik-Basu
Publikováno v:
European Journal of Medicinal Chemistry. 112:33-38
The synthesis of a series of 5-carba-pterocarpens derivatives involving the cyclization of α-aryl-α-tetralones is described. Several compounds demonstrated potent activity and selectivity in vitro against HCV replicon reporter cells. The best profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4cb7cce8be185377f5972956ba7513
https://doi.org/10.1016/j.ejmech.2016.02.010
https://doi.org/10.1016/j.ejmech.2016.02.010
Autor:
Dinesh Manvar, Talita de A. Fernandes, Paulo R. R. Costa, Amartya Basu, Jorge L.O. Domingos, Erdenechimeg Baljinnyam, Eurides F.T. Junior, Neerja Kaushik-Basu
Publikováno v:
European Journal of Medicinal Chemistry. 93:51-54
The synthesis of a novel series of 1-carba-isoflavanones through the α-arylation of α-tetralones is described. Several of these compounds demonstrated potent activity and selectivity in-vitro against HCV replicon reporter cells. Compound 10 (LQB-31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3157b3348f76afd73ef566dabfe6e8f
https://doi.org/10.1016/j.ejmech.2015.01.057
https://doi.org/10.1016/j.ejmech.2015.01.057