Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Jorge L Ruas"'
Autor:
Brennan J Wadsworth, Marina Leiwe, Eleanor A Minogue, Pedro P Cunha, Viktor Engman, Carolin Brombach, Christos Asvestis, Shiv K Sah-Teli, Emilia Marklund, Peppi Koivunen, Jorge L Ruas, Helene Rundqvist, Johanna T Lanner, Randall S Johnson
Publikováno v:
eLife, Vol 12 (2024)
Several metabolites have been shown to have independent and at times unexpected biological effects outside of their metabolic pathways. These include succinate, lactate, fumarate, and 2-hydroxyglutarate. 2-Hydroxybutyrate (2HB) is a byproduct of endo
Externí odkaz:
https://doaj.org/article/a2344de77b9c433ca84e766bf403fa6d
Autor:
Irem Bayindir‐Buchhalter, Gretchen Wolff, Sarah Lerch, Tjeerd Sijmonsma, Maximilian Schuster, Jan Gronych, Adrian T Billeter, Rohollah Babaei, Damir Krunic, Lars Ketscher, Nadine Spielmann, Martin Hrabe de Angelis, Jorge L Ruas, Beat P Müller‐Stich, Mathias Heikenwalder, Peter Lichter, Stephan Herzig, Alexandros Vegiopoulos
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 8, Pp 1-18 (2018)
Abstract Most antidiabetic drugs treat disease symptoms rather than adipose tissue dysfunction as a key pathogenic cause in the metabolic syndrome and type 2 diabetes. Pharmacological targeting of adipose tissue through the nuclear receptor PPARg, as
Externí odkaz:
https://doaj.org/article/a4f7620a706d40c1b743c16d6f4e5f05
Autor:
Mélissa Léveillé, Aurèle Besse-Patin, Nathalie Jouvet, Aysim Gunes, Sarah Sczelecki, Stewart Jeromson, Naveen P. Khan, Cindy Baldwin, Annie Dumouchel, Jorge C. Correia, Paulo R. Jannig, Jonathan Boulais, Jorge L. Ruas, Jennifer L. Estall
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 72-84 (2020)
Objective: The liver is regularly exposed to changing metabolic and inflammatory environments. It must sense and adapt to metabolic need while balancing resources required to protect itself from insult. Peroxisome proliferator activated receptor gamm
Externí odkaz:
https://doaj.org/article/c06589cb7e004ec49cb98361c3eaaf51
Autor:
Duarte M. S. Ferreira, Arthur J. Cheng, Leandro Z. Agudelo, Igor Cervenka, Thomas Chaillou, Jorge C. Correia, Margareta Porsmyr-Palmertz, Manizheh Izadi, Alicia Hansson, Vicente Martínez-Redondo, Paula Valente-Silva, Amanda T. Pettersson-Klein, Jennifer L. Estall, Matthew M. Robinson, K. Sreekumaran Nair, Johanna T. Lanner, Jorge L. Ruas
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-19 (2019)
Abstract Background Skeletal muscle mass and strength are crucial determinants of health. Muscle mass loss is associated with weakness, fatigue, and insulin resistance. In fact, it is predicted that controlling muscle atrophy can reduce morbidity and
Externí odkaz:
https://doaj.org/article/2f827301045e4b2e8bc503169f19361b
Autor:
Yildiz Kelahmetoglu, Paulo R. Jannig, Igor Cervenka, Lauren G. Koch, Steven L. Britton, Jiajia Zhou, Huating Wang, Matthew M. Robinson, K Sreekumaran Nair, Jorge L. Ruas
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Increasing exercise capacity promotes healthy aging and is strongly associated with lower mortality rates. In this study, we analyzed skeletal muscle transcriptomics coupled to exercise performance in humans and rats to dissect the inherent and respo
Externí odkaz:
https://doaj.org/article/8bff6e8df1fa4140a9745a039a4930a2
Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN
Autor:
Christiano R.R. Alves, Willian das Neves, Ney R. de Almeida, Eric J. Eichelberger, Paulo R. Jannig, Vanessa A. Voltarelli, Gabriel C. Tobias, Luiz R.G. Bechara, Daniele de Paula Faria, Maria J.N. Alves, Lars Hagen, Animesh Sharma, Geir Slupphaug, José B.N. Moreira, Ulrik Wisloff, Michael F. Hirshman, Carlos E. Negrão, Gilberto de Castro Jr, Roger Chammas, Kathryn J. Swoboda, Jorge L. Ruas, Laurie J. Goodyear, Patricia C. Brum
Publikováno v:
Molecular Metabolism, Vol 39, Iss , Pp 101012- (2020)
Objective: We tested the hypothesis that exercise training would attenuate metabolic impairment in a model of severe cancer cachexia. Methods: We used multiple in vivo and in vitro methods to explore the mechanisms underlying the beneficial effects i
Externí odkaz:
https://doaj.org/article/be8202df0b80459fac41942eb9eb9047
Autor:
Richard Mills, Hermes Taylor-Weiner, Jorge C. Correia, Leandro Z. Agudelo, Ilary Allodi, Christina Kolonelou, Vicente Martinez-Redondo, Duarte M.S. Ferreira, Susanne Nichterwitz, Laura H. Comley, Vanessa Lundin, Eva Hedlund, Jorge L. Ruas, Ana I. Teixeira
Publikováno v:
Molecular Metabolism, Vol 7, Iss , Pp 12-22 (2018)
Objective: We examined whether skeletal muscle overexpression of PGC-1α1 or PGC-1α4 affected myokine secretion and neuromuscular junction (NMJ) formation. Methods: A microfluidic device was used to model endocrine signaling and NMJ formation betwee
Externí odkaz:
https://doaj.org/article/db87ccbfe02748bf8d9b5cf1f96d5cac
Autor:
Maxwell A. Ruby, Julie Massart, Devon M. Hunerdosse, Milena Schönke, Jorge C. Correia, Sharon M. Louie, Jorge L. Ruas, Erik Näslund, Daniel K. Nomura, Juleen R. Zierath
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 636-646 (2017)
Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. Here, we performed activity-based protein profiling to assess the functional level of serine hydrolases in liver biopsies from lean and obese humans in order
Externí odkaz:
https://doaj.org/article/aa11d88b9e6d4a64a80f36f80d98b06d
Autor:
Jorge C. Correia, Julie Massart, Jan Freark de Boer, Margareta Porsmyr-Palmertz, Vicente Martínez-Redondo, Leandro Z. Agudelo, Indranil Sinha, David Meierhofer, Vera Ribeiro, Marie Björnholm, Sascha Sauer, Karin Dahlman-Wright, Juleen R. Zierath, Albert K. Groen, Jorge L. Ruas
Publikováno v:
Molecular Metabolism, Vol 4, Iss 12, Pp 891-902 (2015)
Objective: Farnesoid X receptor (FXR) plays a prominent role in hepatic lipid metabolism. The FXR gene encodes four proteins with structural differences suggestive of discrete biological functions about which little is known. Methods: We expressed ea
Externí odkaz:
https://doaj.org/article/8ebda816bd19486b9e767bdbd21f6a38
Publikováno v:
Cardiovascular Research. 118:1520-1534
Aims Biological sex has fundamental effects on mammalian heart physiology and pathogenesis. While it has been established that female sex is a protective factor against most cardiovascular diseases (CVDs), this beneficial effect may involve pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfe2d70d7994823c4f6087ef96f87cf
https://doi.org/10.1093/cvr/cvab188
https://doi.org/10.1093/cvr/cvab188