Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Jorge L, Rodriguez"'
Autor:
Laura L. Baxter, Dawn E. Watkins-Chow, Nicholas L. Johnson, Nicole Y. Farhat, Frances M. Platt, Ryan K. Dale, Forbes D. Porter, William J. Pavan, Jorge L. Rodriguez-Gil
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Niemann–Pick disease type C1 (NPC1) is a rare, prematurely fatal lysosomal storage disorder which exhibits highly variable severity and disease progression as well as a wide-ranging age of onset, from perinatal stages to adulthood. This he
Externí odkaz:
https://doaj.org/article/ca15cd7d85e544589362b1541d47b189
Autor:
Babatunde Adedokun, Zhaohui Du, Guimin Gao, Thomas U. Ahearn, Kathryn L. Lunetta, Gary Zirpoli, Jonine Figueroa, Esther M. John, Leslie Bernstein, Wei Zheng, Jennifer J. Hu, Regina G. Ziegler, Sarah Nyante, Elisa V. Bandera, Sue A. Ingles, Michael F. Press, Sandra L. Deming-Halverson, Jorge L. Rodriguez-Gil, Song Yao, Temidayo O. Ogundiran, Oladosu Ojengbede, William Blot, Melissa A. Troester, Katherine L. Nathanson, Anselm Hennis, Barbara Nemesure, Stefan Ambs, Peter N. Fiorica, Lara E. Sucheston-Campbell, Jeannette T. Bensen, Lawrence H. Kushi, Gabriela Torres-Mejia, Donglei Hu, Laura Fejerman, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Kyriaki Michailidou, Paul D. P. Pharoah, Qin Wang, Dale P. Sandler, Jack A. Taylor, Katie M. O’Brien, Cari M. Kitahara, Adeyinka G. Falusi, Chinedum Babalola, Joel Yarney, Baffour Awuah, Beatrice Addai-Wiafe, The GBHS Study Team, Stephen J. Chanock, Andrew F. Olshan, Christine B. Ambrosone, David V. Conti, Elad Ziv, Olufunmilayo I. Olopade, Montserrat Garcia-Closas, Julie R. Palmer, Christopher A. Haiman, Dezheng Huo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
GWAS have enhanced our understanding for the genetic basis of breast cancer, but the majority of them were performed for European ancestry populations. Here, the authors use a cross-ancestry approach and report seven new variants associated with brea
Externí odkaz:
https://doaj.org/article/6f0e5304a68d47149e5deb98e9b77d0a
Autor:
Nury N Olaya-Galán, Sandra P Salas-Cárdenas, Jorge L Rodriguez-Sarmiento, Milcíades Ibáñez-Pinilla, Ricardo Monroy, Adriana P Corredor-Figueroa, Wilson Rubiano, Jairo de la Peña, HuaMin Shen, Gertrude C Buehring, Manuel A Patarroyo, Maria F Gutierrez
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257492 (2021)
Viruses have been implicated in cancer development in both humans and animals. The role of viruses in cancer is typically to initiate cellular transformation through cellular DNA damage, although specific mechanisms remain unknown. Silent and long-te
Externí odkaz:
https://doaj.org/article/b471e74620b34cfba709d6d5790fe2ee
Autor:
Jorge L. Rodriguez-Gil, Dawn E. Watkins-Chow, Laura L. Baxter, Gene Elliot, Ursula L. Harper, Stephen M. Wincovitch, Julia C. Wedel, Arturo A. Incao, Mylene Huebecker, Frederick J. Boehm, William S. Garver, Forbes D. Porter, Karl W. Broman, Frances M. Platt, William J. Pavan
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 3 (2020)
Niemann-Pick disease type C1 (NPC1) is a rare, fatal neurodegenerative disorder characterized by lysosomal accumulation of unesterified cholesterol and glycosphingolipids. These subcellular pathologies lead to phenotypes of hepatosplenomegaly, neurol
Externí odkaz:
https://doaj.org/article/ef50034038734837b8a67902b9084e8d
Autor:
Maureen E. Murphy, Song Liu, Song Yao, Dezheng Huo, Qin Liu, Sonia C. Dolfi, Kim M. Hirshfield, Chi-Chen Hong, Qiang Hu, Andrew F. Olshan, Temidayo O. Ogundiran, Clement Adebamowo, Susan M. Domchek, Katherine L. Nathanson, Barbara Nemesure, Stefan Ambs, William J. Blot, Ye Feng, Esther M. John, Leslie Bernstein, Wei Zheng, Jennifer J. Hu, Regina G. Ziegler, Sarah Nyante, Sue A. Ingles, Michael F. Press, Sandra L. Deming, Jorge L. Rodriguez-Gil, Christopher A. Haiman, Olufunmilayo I. Olopade, Kathryn L. Lunetta, Julie R. Palmer, Christine B. Ambrosone
Publikováno v:
npj Breast Cancer, Vol 3, Iss 1, Pp 1-4 (2017)
Genetics: Variant may increase cancer risk in pre-menopausal black women A gene variant found in people of African descent may increase the risk of breast cancer—but only among pre-menopausal women. In a study of more than 14,000 women of African a
Externí odkaz:
https://doaj.org/article/6cbf07c525e841a38a28b2739e09d08a
Autor:
Wendy Westbroek, Matthew Nguyen, Marina Siebert, Taylor Lindstrom, Robert A. Burnett, Elma Aflaki, Olive Jung, Rafael Tamargo, Jorge L. Rodriguez-Gil, Walter Acosta, An Hendrix, Bahafta Behre, Nahid Tayebi, Hideji Fujiwara, Rohini Sidhu, Benoit Renvoise, Edward I. Ginns, Amalia Dutra, Evgenia Pak, Carole Cramer, Daniel S. Ory, William J. Pavan, Ellen Sidransky
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 7, Pp 769-778 (2016)
Glucocerebrosidase is a lysosomal hydrolase involved in the breakdown of glucosylceramide. Gaucher disease, a recessive lysosomal storage disorder, is caused by mutations in the gene GBA1. Dysfunctional glucocerebrosidase leads to accumulation of glu
Externí odkaz:
https://doaj.org/article/f7b3e5e990b84865ae7b2fc4d4fb9cb0
Autor:
Christopher A. Haiman, Julie R. Palmer, Olufunmilayo I. Olopade, Daniel O. Stram, Gerhard A. Coetzee, David V. Conti, Laurence N. Kolonel, Andrew F. Olshan, Loic Le Marchand, Stephen J. Chanock, Jeannette T. Bensen, Lara E. Sucheston-Campbell, Kathryn L. Lunetta, Katherine L. Nathanson, Lisa Signorello, Qiuyin Cai, William Blot, Stefan Ambs, Barbara Nemesure, Anselm Hennis, Adeyinka G. Falusi, Oladosu Ojengbede, Clement Adebamowo, Timothy R. Rebbeck, Temidayo O. Ogundiran, Yoo-Jeong Han, Song Yao, Yonglan Zheng, Jorge L. Rodriguez-Gil, Sandra L. Deming, Michael F. Press, Sue A. Ingles, Elisa V. Bandera, Sarah Nyante, Regina G. Ziegler, Jennifer J. Hu, Wei Zheng, Leslie Bernstein, Esther M. John, Christine B. Ambrosone, Stephen A. Haddad, Edward A. Ruiz-Narvaez, Dezheng Huo, Suhn Kyong Rhie, Ye Feng
Supplementary Table S1. Associations of Overall Breast Cancer Risk with 74 Breast Cancer Risk Variants in African Americans with Study-specific Results.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f7e783bfd4bf36aef792d7864a1495
https://doi.org/10.1158/1055-9965.22436271.v1
https://doi.org/10.1158/1055-9965.22436271.v1
Autor:
Christopher A. Haiman, Julie R. Palmer, Olufunmilayo I. Olopade, Daniel O. Stram, Gerhard A. Coetzee, David V. Conti, Laurence N. Kolonel, Andrew F. Olshan, Loic Le Marchand, Stephen J. Chanock, Jeannette T. Bensen, Lara E. Sucheston-Campbell, Kathryn L. Lunetta, Katherine L. Nathanson, Lisa Signorello, Qiuyin Cai, William Blot, Stefan Ambs, Barbara Nemesure, Anselm Hennis, Adeyinka G. Falusi, Oladosu Ojengbede, Clement Adebamowo, Timothy R. Rebbeck, Temidayo O. Ogundiran, Yoo-Jeong Han, Song Yao, Yonglan Zheng, Jorge L. Rodriguez-Gil, Sandra L. Deming, Michael F. Press, Sue A. Ingles, Elisa V. Bandera, Sarah Nyante, Regina G. Ziegler, Jennifer J. Hu, Wei Zheng, Leslie Bernstein, Esther M. John, Christine B. Ambrosone, Stephen A. Haddad, Edward A. Ruiz-Narvaez, Dezheng Huo, Suhn Kyong Rhie, Ye Feng
Supplementary Figure S1, Supplementary Figure S1. Regional plots of 3p24, 11q13, 12p11, 14q13, 16q12/TOX3, 16q12/FTO, 16q23, and 19p13.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2953e406dedef5f0a92b74783aedd3b9
https://doi.org/10.1158/1055-9965.22436277
https://doi.org/10.1158/1055-9965.22436277
Autor:
Christopher A. Haiman, Julie R. Palmer, Olufunmilayo I. Olopade, Daniel O. Stram, Gerhard A. Coetzee, David V. Conti, Laurence N. Kolonel, Andrew F. Olshan, Loic Le Marchand, Stephen J. Chanock, Jeannette T. Bensen, Lara E. Sucheston-Campbell, Kathryn L. Lunetta, Katherine L. Nathanson, Lisa Signorello, Qiuyin Cai, William Blot, Stefan Ambs, Barbara Nemesure, Anselm Hennis, Adeyinka G. Falusi, Oladosu Ojengbede, Clement Adebamowo, Timothy R. Rebbeck, Temidayo O. Ogundiran, Yoo-Jeong Han, Song Yao, Yonglan Zheng, Jorge L. Rodriguez-Gil, Sandra L. Deming, Michael F. Press, Sue A. Ingles, Elisa V. Bandera, Sarah Nyante, Regina G. Ziegler, Jennifer J. Hu, Wei Zheng, Leslie Bernstein, Esther M. John, Christine B. Ambrosone, Stephen A. Haddad, Edward A. Ruiz-Narvaez, Dezheng Huo, Suhn Kyong Rhie, Ye Feng
Supplementary Fig Leg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6fb301f8c99c68385a6af884aae910
https://doi.org/10.1158/1055-9965.22436280.v1
https://doi.org/10.1158/1055-9965.22436280.v1
Autor:
Christopher A. Haiman, Julie R. Palmer, Olufunmilayo I. Olopade, Daniel O. Stram, Gerhard A. Coetzee, David V. Conti, Laurence N. Kolonel, Andrew F. Olshan, Loic Le Marchand, Stephen J. Chanock, Jeannette T. Bensen, Lara E. Sucheston-Campbell, Kathryn L. Lunetta, Katherine L. Nathanson, Lisa Signorello, Qiuyin Cai, William Blot, Stefan Ambs, Barbara Nemesure, Anselm Hennis, Adeyinka G. Falusi, Oladosu Ojengbede, Clement Adebamowo, Timothy R. Rebbeck, Temidayo O. Ogundiran, Yoo-Jeong Han, Song Yao, Yonglan Zheng, Jorge L. Rodriguez-Gil, Sandra L. Deming, Michael F. Press, Sue A. Ingles, Elisa V. Bandera, Sarah Nyante, Regina G. Ziegler, Jennifer J. Hu, Wei Zheng, Leslie Bernstein, Esther M. John, Christine B. Ambrosone, Stephen A. Haddad, Edward A. Ruiz-Narvaez, Dezheng Huo, Suhn Kyong Rhie, Ye Feng
Background: Genome-wide association studies have identified approximately 100 common genetic variants associated with breast cancer risk, the majority of which were discovered in women of European ancestry. Because of different patterns of linkage di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326c7c479414d08da4b0807f44977385
https://doi.org/10.1158/1055-9965.c.6515301
https://doi.org/10.1158/1055-9965.c.6515301