Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jorge Guzman-Lepe"'
Autor:
Edgar N. Tafaleng, Amitava Mukherjee, Aaron Bell, Kazutoyo Morita, Jorge Guzman‐Lepe, Nils Haep, Rodrigo M. Florentino, Ricardo Diaz‐Aragon, Carla Frau, Alina Ostrowska, Joshua R. Schultz, Paolo G. V. Martini, Alejandro Soto‐Gutierrez, Ira J. Fox
Publikováno v:
Hepatology Communications, Vol 5, Iss 11, Pp 1911-1926 (2021)
The only definitive therapy for end‐stage liver disease is whole‐organ transplantation. The success of this intervention is severely limited by the complexity of the surgery, the cost of patient care, the need for long‐term immunosuppression, a
Externí odkaz:
https://doaj.org/article/eefaa6013f164a9e83b52ff3fa2c4cc8
Autor:
Rodrigo M. Florentino, Nicolas A. Fraunhoffer, Kazutoyo Morita, Kazuki Takeishi, Alina Ostrowska, Abhinav Achreja, Olamide Animasahun, Nils Haep, Shohrat Arazov, Nandini Agarwal, Alexandra Collin de l'Hortet, Jorge Guzman‐Lepe, Edgar N. Tafaleng, Amitava Mukherjee, Kris Troy, Swati Banerjee, Shirish Paranjpe, George K. Michalopoulos, Aaron Bell, Deepak Nagrath, Sarah J. Hainer, Ira J. Fox, Alejandro Soto‐Gutierrez
Publikováno v:
Hepatology Communications, Vol 4, Iss 6, Pp 859-875 (2020)
Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a critical role in hepatocyte function, and HNF4α‐based reprogramming corrects terminal liver failure in rats with chronic liver disease. In the livers of patients wit
Externí odkaz:
https://doaj.org/article/a366b3ff63454cfe85adee4824c052ae
Autor:
Kazuki Takeishi, Alexandra Collin de l’Hortet, Yang Wang, Kan Handa, Jorge Guzman-Lepe, Kentaro Matsubara, Kazutoyo Morita, Sae Jang, Nils Haep, Rodrigo M. Florentino, Fangchao Yuan, Ken Fukumitsu, Kimimasa Tobita, Wendell Sun, Jonathan Franks, Evan R. Delgado, Erik M. Shapiro, Nicolas A. Fraunhoffer, Andrew W. Duncan, Hiroshi Yagi, Tomoji Mashimo, Ira J. Fox, Alejandro Soto-Gutierrez
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a bioengineered human liver derived from induced pluripotent stem cells (iPSCs) has n
Externí odkaz:
https://doaj.org/article/2669d2ed58534d89a4a0eccc2bf0473f
Autor:
Takamasa Tobita, Jorge Guzman-Lepe, Kazuki Takeishi, Toshimasa Nakao, Yang Wang, Fanying Meng, Chu-Xia Deng, Alexandra Collin de l'Hortet, Alejandro Soto-Gutierrez
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149344 (2016)
There are unprecedented epidemics of obesity, such as type II diabetes and non-alcoholic fatty liver diseases (NAFLD) in developed countries. A concerning percentage of American children are being affected by obesity and NAFLD. Studies have suggested
Externí odkaz:
https://doaj.org/article/c62d8a4077434fafb542fe025ce4aff0
Autor:
Marc C. Hansel, Roberto Gramignoli, William Blake, Julio Davila, Kristen Skvorak, Kenneth Dorko, Veysel Tahan, Brian R. Lee, Edgar Tafaleng, Jorge Guzman-Lepe, Alejandro Soto-Gutierrez, Ira J. Fox, Stephen C. Strom
Publikováno v:
Cell Transplantation, Vol 23 (2014)
Hepatocyte transplantation has been used to treat liver disease. The availability of cells for these procedures is quite limited. Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) may be a useful source of hepatocytes for
Externí odkaz:
https://doaj.org/article/a791c72535254c10a9d800f6a525d466
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/62eafe483e3a4850ab384a3fc3016ad4
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/fb9cbd0cb5df47499fffdaeaf893ed33
Autor:
Shirish Paranjpe, George K. Michalopoulos, Nicolas A. Fraunhoffer, Jorge Guzman-Lepe, Aaron Bell, Sarah J. Hainer, Kazutoyo Morita, Rodrigo M. Florentino, Kris Troy, Kazuki Takeishi, Nandini Agarwal, Alejandro Soto-Gutierrez, Olamide Animasahun, Nils Haep, Amitava Mukherjee, Alina Ostrowska, Deepak Nagrath, Swati Banerjee, Ira J. Fox, Shohrat Arazov, Abhinav Achreja, Alexandra Collin de l'Hortet, Edgar N. Tafaleng
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Hepatology Communications, Vol 4, Iss 6, Pp 859-875 (2020)
Hepatology Communications
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Hepatology Communications, Vol 4, Iss 6, Pp 859-875 (2020)
Hepatology Communications
Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a critical role in hepatocyte function, and HNF4α‐based reprogramming corrects terminal liver failure in rats with chronic liver disease. In the livers of patients wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da96665139b09dfb6dc80d389bde5a0
Wiley Online Library
Wiley Online Library
Autor:
Erik M. Shapiro, Sae Jang, Rodrigo M. Florentino, Ira J. Fox, Tomoji Mashimo, Kan Handa, Andrew W. Duncan, Fangchao Yuan, Wendell Sun, Jorge Guzman-Lepe, Alexandra Collin de l'Hortet, Nils Haep, Kimimasa Tobita, Alejandro Soto-Gutierrez, Evan R. Delgado, Hiroshi Yagi, Nicolas A. Fraunhoffer, Kazuki Takeishi, Kentaro Matsubara, Yang Wang, Kazutoyo Morita, Jonathan Franks, Ken Fukumitsu
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp-(2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a bioengineered human liver derived from induced pluripotent stem cells (iPSCs) has not been p
Autor:
Kazuki Takeishi, Ji-ye Zhu, Alexandra Collin de l'Hortet, Zhao Li, Xiao Cui, Jorge Guzman-Lepe, Yang Wang, Eduardo Cervantes-Alvarez
Publikováno v:
Organogenesis. 13:83-94
Organ-like microenviroment and 3-dimensional (3D) cell culture conformations have been suggested as promising approaches to mimic in a micro-scale a whole organ cellular functions and interactions present in vivo. We have used this approach to examin