Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jorge Gomez-Galeno"'
Autor:
Jorge Gomez‐Galeno, Karl Okolotowicz, Mark Johnson, Wesley L. McKeithan, Mark Mercola, John R. Cashman
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract Prolongation of the cardiac action potential (AP) and early after depolarizations (EADs) are electrical anomalies of cardiomyocytes that can lead to lethal arrhythmias and are potential liabilities for existing drugs and drug candidates in d
Externí odkaz:
https://doaj.org/article/0aa03a93ca524ad2bceee95b8a4542e8
Autor:
Arash Pezhouman, Karl J. Okolotowicz, Wesley L. McKeithan, Robert S. Kass, John R. Cashman, Jorge Gomez-Galeno, Kevin J. Sampson, Mark Johnson, Mark Mercola, Hrayr S. Karagueuzian, Daniel P. Ryan
Publikováno v:
Journal of Medicinal Chemistry. 64:5384-5403
Ventricular cardiac arrhythmia (VA) arises in acquired or congenital heart disease. Long QT syndrome type-3 (LQT3) is a congenital form of VA caused by cardiac sodium channel (INaL) SCN5A mutations that prolongs cardiac action potential (AP) and enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5c7f0dd305d00d80d3c4b895bff882
https://doi.org/10.1021/acs.jmedchem.0c01545
https://doi.org/10.1021/acs.jmedchem.0c01545
Autor:
Karl J. Okolotowicz, Jorge Gomez-Galeno, John R. Cashman, Wesley L. McKeithan, Mark R. Johnson, Mark Mercola
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
Prolongation of the cardiac action potential (AP) and early after depolarizations (EADs) are electrical anomalies of cardiomyocytes that can lead to lethal arrhythmias and are potential liabilities for existing drugs and drug candidates in developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339f1a3ade44b806486f27bb4c2fe866
https://doi.org/10.1002/prp2.828
https://doi.org/10.1002/prp2.828
Autor:
Jorge Gomez-Galeno, Wesley L. McKeithan, Kevin J. Sampson, Daniel P. Ryan, John R. Cashman, Mark Mercola, Karl J. Okolotowicz, Mark S. Johnson, Robert S. Kass
Publikováno v:
Bioorganicmedicinal chemistry letters. 46
In the United States, approximately one million individuals are hospitalized every year for arrhythmias, making arrhythmias one of the top causes of healthcare expenditures. Mexiletine is currently used as an antiarrhythmic drug but has limitations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29eb1ae39b7c7b74f4b845f968af4238
https://pubmed.ncbi.nlm.nih.gov/34062251
https://pubmed.ncbi.nlm.nih.gov/34062251
Autor:
Jorge Gomez-Galeno, Pilar Ruiz-Lozano, Philip Janiak, Raeeun Chung, Christopher J. Larson, Alena Safarova, Suzuki Teri, Cecilia Hurtado, John R. Cashman, Franz Oswald, Arne A. N. Bruyneel, Mark Mercola, Michael L. Smith
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
NOTCH plays a pivotal role during normal development and in congenital disorders and cancer. γ-secretase inhibitors are commonly used to probe NOTCH function, but also block processing of numerous other proteins. We discovered a new class of small m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca27347922b576fb4295c5b6d12121d
http://hdl.handle.net/10044/1/82415
http://hdl.handle.net/10044/1/82415
Autor:
Dong-Hoon Lee, Jiongjia Cheng, Karl J. Okolotowicz, Jorge Gomez-Galeno, Stephanie Moore, John R. Cashman
Publikováno v:
J Pharmacol Exp Ther
Prostate cancer (PCa) is the second leading cause of cancer-related death for men in the United States. Approximately 35% of PCa recurs and is often transformed to castration-resistant prostate cancer (CRPCa), the most deadly and aggressive form of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cc7ba85e8f9c73d769b2fd8122c150
https://pubmed.ncbi.nlm.nih.gov/31582422
https://pubmed.ncbi.nlm.nih.gov/31582422
Autor:
Dries A.M. Feyen, Franck Potet, Kevin J. Sampson, Daniel A. Ryan, Wesley L. McKeithan, Alfred L. George, Michelle Vu, Jorge Gomez-Galeno, Ricardo Serrano, Arne A. N. Bruyneel, Mark Mercola, Robert S. Kass, John R. Cashman, Karl J. Okolotowicz, Alex Savchenko
Publikováno v:
Cell Stem Cell
Modelling cardiac disorders with human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes is a new paradigm for preclinical testing of candidate therapeutics. However, disease-relevant physiological assays can be complex, and the use of hiP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09cee085acf16a9f1c8839243162c43
https://doi.org/10.1016/j.stem.2020.08.003
https://doi.org/10.1016/j.stem.2020.08.003
Publikováno v:
Cancer Research. 80:694-694
Today, pancreatic cancer (PC) remains a major health problem in the US and soon will be the second most common cause of mortality due to cancer. However, most of the front-line PC chemotherapies cause serious side effects and a majority of patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac801fbcb289ff58463f82f70b51d27c
https://doi.org/10.1158/1538-7445.am2020-694
https://doi.org/10.1158/1538-7445.am2020-694
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81fa7f198ed85ee5810cca8bfd58e949
https://doi.org/10.1096/fasebj.2020.34.s1.05853
https://doi.org/10.1096/fasebj.2020.34.s1.05853
Autor:
John R. Cashman, Jiongjia Cheng, Cecilia Hurtado, Ceren Yardimci, Jorge Gomez-Galeno, Mark Mercola
The Notch signaling pathway is involved in cell proliferation and differentiation, and has been recognized as an active pathway in regenerating tissue and cancerous cells. Notch signaling inhibition is considered a viable approach to the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a708c47ec1eef4b43088b9d87f12d6
https://europepmc.org/articles/PMC6261437/
https://europepmc.org/articles/PMC6261437/