Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jorge Fernandez de Cossio-Diaz"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Adeno-associated viruses 2 (AAV2) are minute viruses renowned for their capacity to infect human cells and akin organisms. They have recently emerged as prominent candidates in the field of gene therapy, primarily attributed to their inheren
Externí odkaz:
https://doaj.org/article/553499d5eb064011adeae295355f32b3
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011812 (2024)
The design of proteins with specific tasks is a major challenge in molecular biology with important diagnostic and therapeutic applications. High-throughput screening methods have been developed to systematically evaluate protein activity, but only a
Externí odkaz:
https://doaj.org/article/748fac7a95b3481d9d0044122031bc14
Autor:
Lisandra Calzadilla, Erick Hernández, Julio Dustet, Jorge Fernandez-de-Cossio-Diaz, Kalet León, Matthias Pietzke, Alexei Vazquez, Roberto Mulet, Tammy Boggiano
Publikováno v:
Data in Brief, Vol 50, Iss , Pp 109604- (2023)
The data for provide evidences of the multi steady state of the human cell line HEK 293 was obtained from 2 L bioreactor continuous culture. A HEK 293 cell line transfected to produce soluble HER1 receptor was used. The bioreactor was operated at thr
Externí odkaz:
https://doaj.org/article/162fa46759614a488b8f103b64d26fc1
Autor:
Barbara Bravi, Andrea Di Gioacchino, Jorge Fernandez-de-Cossio-Diaz, Aleksandra M Walczak, Thierry Mora, Simona Cocco, Rémi Monasson
Publikováno v:
eLife, Vol 12 (2023)
Antigen immunogenicity and the specificity of binding of T-cell receptors to antigens are key properties underlying effective immune responses. Here we propose diffRBM, an approach based on transfer learning and Restricted Boltzmann Machines, to buil
Externí odkaz:
https://doaj.org/article/3aa7f87a1a4c4800a52f77d2f9c090cd
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105450- (2022)
Summary: The study of cellular metabolism is limited by the amount of experimental data available. Formulations able to extract relevant predictions from accessible measurements are needed. Maximum Entropy (ME) inference has been successfully applied
Externí odkaz:
https://doaj.org/article/418cd9d83f9e4a86af29f9074d9c6cfe
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Large molecular interaction networks are nowadays assembled in biomedical researches along with important technological advances. Diverse interaction measures, for which input solely consisting of the incidence of causal-factors, with the co
Externí odkaz:
https://doaj.org/article/1b80e32ab13549fb8b8eefb924588324
Publikováno v:
Physical Review X, Vol 13, Iss 2, p 021003 (2023)
A goal of unsupervised machine learning is to build representations of complex high-dimensional data, with simple relations to their properties. Such disentangled representations make it easier to interpret the significant latent factors of variation
Externí odkaz:
https://doaj.org/article/b76a351ce38b4ae8a8779680705032d1
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract We introduce an in silico model for the initial spread of an aberrant phenotype with Warburg-like overflow metabolism within a healthy homeostatic tissue in contact with a nutrient reservoir (the blood), aimed at characterizing the role of t
Externí odkaz:
https://doaj.org/article/acdfbc10cd054f6e83d572d0d68f32e0
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006823 (2019)
Continuous cultures of mammalian cells are complex systems displaying hallmark phenomena of nonlinear dynamics, such as multi-stability, hysteresis, as well as sharp transitions between different metabolic states. In this context mathematical models
Externí odkaz:
https://doaj.org/article/111f4e84f9f24a189c756bda8c53decc
The design of proteins with specific tasks is a major challenge in molecular biology with important diagnostic and therapeutic applications. High-throughput screening methods have been developed to systematically evaluate protein activity, but only a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45cdf49b8123ff9d161c3b145d30576b
https://doi.org/10.1101/2023.05.19.541442
https://doi.org/10.1101/2023.05.19.541442
