Výsledky vyhledávání - "Jorge F. Gaspar"

(1–3)-Beta-D-glucan in association with lactate dehydrogenase as biomarkers of Pneumocystis pneumonia (PcP) in HIV-infected patients

Autor: Camila Fernandes, R. Badura, Francisco de Assis Esteves, M. Seringa, Francisco Antunes, Chao-Hung Lee, Olga Matos, B. de Sousa, Jorge F. Gaspar

Publikováno v: European Journal of Clinical Microbiology & Infectious Diseases. 33:1173-1180

Pneumocystis pneumonia (PcP) is a major HIV-related illness caused by Pneumocystis jirovecii. Definitive diagnosis of PcP requires microscopic detection of P. jirovecii in pulmonary specimens. The objective of this study was to evaluate the usefulnes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9057800e6023b6904e949da8c7e8cdfa
https://doi.org/10.1007/s10096-014-2054-6

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Abstract P2-13-01: The Brazilian founder TP53 p.R337H mutation is uncommon in Portuguese women diagnosed with breast cancer

Autor: C Portela, Jorge F. Gaspar, Rui Manuel Reis, Rudinei Luis Correia, Suzi Alves Camey, Juliana Giacomazzi, Maria Inês Almeida, Patricia Ashton-Prolla, Edenir Inêz Palmero

Publikováno v: Cancer Research. 73:P2-13

Since the first studies reporting the TP53 p.R337H mutation as founder mutation in Southern and Southeastern regions of Brazil, both in the general population and in patients from high risk breast cancer families with adrenocortical, choroid plexus a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::573a8fcc125bbb1177990e6badc67256
https://doi.org/10.1158/0008-5472.sabcs13-p2-13-01

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Genotoxic effect of exposure to metal(loid)s. A molecular epidemiology survey of populations living and working in Panasqueira mine area, Portugal

Autor: João Pereira de Lima, Blanca Laffon, Valentina Dall'Armi, Roberto Zoffoli, Carla Costa, Eduardo Pásaro, Stefano Bonassi, Susana Silva, Patrícia Coelho, Julia García-Lestón, Solange Costa, Jorge F. Gaspar, João Paulo Teixeira

Publikováno v: Environment International, Vol 60, Iss, Pp 163-170 (2013)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Previous studies investigating the exposure to metal(loid)s of populations living in the Panasqueira mine area of central Portugal found a higher internal dose of elements such as arsenic, chromium, lead, manganese, molybdenum and zinc in exposed ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768d0e68fd17f9065ff1af73cf3a97bf
https://doi.org/10.1016/j.envint.2013.08.014

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Induction of sister chromatid exchange by acrylamide and glycidamide in human lymphocytes: Role of polymorphisms in detoxification and DNA-repair genes in the genotoxicity of glycidamide

Autor: Nuno G. Oliveira, Célia Martins, José Rueff, João Pereira de Lima, Bruno Gomes, Marta Pingarilho, Jorge F. Gaspar, Vanda Martins, Anatalia Labilloy, Ana Sofia Fernandes

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 752:1-7

Acrylamide (AA) is a probable human carcinogen generated in carbohydrate-rich foodstuffs upon heating. Glycidamide (GA), formed via epoxidation, presumably mediated by cytochrome P450 2E1, is considered to be the active metabolite that plays a centra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce0855f9273f4f0b14fa98ab31902e9
https://doi.org/10.1016/j.mrgentox.2012.12.013

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Pneumocystis jirovecii multilocus genotyping in pooled DNA samples: a new approach for clinical and epidemiological studies

Autor: B. de Sousa, Francisco de Assis Esteves, Jorge F. Gaspar, Olga Matos, Francisco Antunes, Kamal Mansinho

Publikováno v: Clinical Microbiology and Infection. 18:E177-E184

Specific single-nucleotide polymorphisms (SNPs) are recognized as important DNA sequence variations influencing the pathogenesis of Pneumocystis jirovecii and the clinical outcome of Pneumocystis pneumonia, which is a major worldwide cause of illness

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288a64910666d5ac6585f7639f27cb73
https://doi.org/10.1111/j.1469-0691.2012.03828.x

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Clinical Relevance of Multiple Single-Nucleotide Polymorphisms in Pneumocystis jirovecii Pneumonia: Development of a Multiplex PCR-Single-Base-Extension Methodology

Autor: Francisco de Assis Esteves, Olga Matos, Francisco Antunes, Kamal Mansinho, B. de Sousa, Jorge F. Gaspar

Publikováno v: Journal of Clinical Microbiology. 49:1810-1815

Pneumocystis jirovecii pneumonia (PcP) is a major cause of respiratory illness in patients with AIDS. The identification of multiple single-nucleotide polymorphisms (SNPs) at three distinct P. jirovecii loci encoding dihydrofolate reductase ( DHFR ),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42124f9116f0bd33214c118c53141e36
https://doi.org/10.1128/jcm.02303-10

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Identification of relevant single-nucleotide polymorphisms in Pneumocystis jirovecii: relationship with clinical data

Autor: Kamal Mansinho, Francisco Antunes, T. Marques, Romulo Leite, Olga Matos, Francisco de Assis Esteves, Jorge F. Gaspar

Publikováno v: Universidade Nova de Lisboa

Pneumocystis jirovecii is a poorly understood pathogen that causes opportunistic pneumonia (Pneumocystis pneumonia (PcP)) in patients with AIDS. The present study was aimed at correlating genetic differences in P. jirovecii isolates and clinical pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a6150e7b71665d402152c1aca96448
https://doi.org/10.1111/j.1469-0691.2009.03030.x

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8,15-Epoxylabdane and norlabdane diterpenoids from Eragrostis viscosa

Autor: Célia Martins, Dina I.M.D. de Mendonça, Inês J.S. Cordeiro, Carlos Diakanamwa, Aldenir Feitosa dos Santos, Antônio Euzébio Goulart Santana, N’Soki N. Sebastião, Jorge F. Gaspar, José Rueff

Publikováno v: Phytochemistry. 71:798-803

Four labdanes with a 8alpha,15-epoxy ring (8alpha,15-epoxylabdan-16beta-oic acid; 8alpha,15-epoxy-16-norlabdan-13-one; 8alpha,15-epoxy-16-norlabdane; and 16-acetoxy-8alpha,15-epoxylabdane) and the known compound ambreinolide were isolated from the he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5054001cbfa6a4b8f4d050fc14e4c3
https://doi.org/10.1016/j.phytochem.2010.02.003

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Population structure of Pneumocystis jirovecii isolated from immunodeficiency virus-positive patients

Autor: Adélcia Tavares, Inês Moser, Jorge F. Gaspar, Francisco Antunes, Olga Matos, Kamal Mansinho, Francisco de Assis Esteves

Publikováno v: Infection, Genetics and Evolution. 10:192-199

Pneumocystis jirovecii pneumonia (PcP) is an important opportunistic infection among immunocompromised patients. Genetic characterization of P. jirovecii isolated from HIV-positive patients, based on identification of multiple nucleotide sequences at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f37ac9d1e5d2093acde8539d456d51
https://doi.org/10.1016/j.meegid.2009.12.007

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Biological assays and noncovalent interactions of pyridine-2-carbaldehyde thiosemicarbazonecopper(II) drugs with [poly(dA–dT)]2, [poly(dG–dC)]2, and calf thymus DNA

Autor: Natalia Busto, Jorge F. Gaspar, R. Ruiz, José M. Leal, Rubén Gil-García, Marta González-Álvarez, Javier García-Tojal, Célia Martins, Saturnino Ibeas, Joaquín Borrás, Begoña García

Publikováno v: JBIC Journal of Biological Inorganic Chemistry. 15:515-532

The interaction of the Cu(II) drugs CuL(NO(3)) and CuL'(NO(3)) (HL is pyridine-2-carbaldehyde thiosemicarbazone and HL' is pyridine-2-carbaldehyde 4N-methylthiosemicarbazone, in water named [CuL](+) and [CuL'](+)) with [poly(dA-dT)](2), [poly(dG-dC)]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a74d0244d2d44b2c22387ada2c93cf4
https://doi.org/10.1007/s00775-009-0620-7

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