Iduronate-2-sulfatase interactome: validation by yeast two-hybrid assay

Autor: Eliana Benincore-Flórez, Jorge El-Azaz, Gabriela Alejandra Solarte, Alexander Rodríguez, Luis H. Reyes, Carlos Javier Alméciga-Díaz, Carolina Cardona-Ramírez

Publikováno v: Heliyon, Vol 8, Iss 3, Pp e09031- (2022)

Background: Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a rare X-linked recessive disease caused by a deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS), which activates intracellular accumulation of nonmetab

Externí odkaz: https://doaj.org/article/2812baf2325d47e48b41520ab1e921c6

Biosynthesis and metabolic fate of phenylalanine in conifers

Autor: María Belén Pascual, Jorge El-Azaz, Fernando N. de la Torre, Rafael A. Cañas, Concepción Avila, Francisco M Cánovas

Publikováno v: Frontiers in Plant Science, Vol 7 (2016)

The amino acid phenylalanine (Phe) is a critical metabolic node that plays an essential role in the interconnection between primary and secondary metabolism in plants. Phe is used as a protein building block but it is also as a precursor for numerous

Externí odkaz: https://doaj.org/article/c57719c8c3374fdcb419d1a4975e6445

Maritime Pine Genomics in Focus

Autor: Lieven Sterck, Nuria de María, Rafael A. Cañas, Marina de Miguel, Pedro Perdiguero, Annie Raffin, Katharina B. Budde, Miriam López-Hinojosa, Francisco R. Cantón, Andreia S. Rodrigues, Marian Morcillo, Agathe Hurel, María Dolores Vélez, Fernando N. de la Torre, Inês Modesto, Lorenzo Federico Manjarrez, María Belén Pascual, Ana Alves, Isabel Mendoza-Poudereux, Marta Callejas Díaz, Alberto Pizarro, Jorge El-Azaz, Laura Hernández-Escribano, María Ángeles Guevara, Juan Majada, Jerome Salse, Delphine Grivet, Laurent Bouffier, Rosa Raposo, Amanda R. De La Torre, Rafael Zas, José Antonio Cabezas, Concepción Ávila, Jean-Francois Trontin, Leopoldo Sánchez, Ricardo Alía, Isabel Arrillaga, Santiago C. González-Martínez, Célia Miguel, Francisco M. Cánovas, Christophe Plomion, Carmen Díaz-Sala, María Teresa Cervera

Publikováno v: The Pine Genomes. Compendium of Plant Genomes
Compendium of Plant Genomes ISBN: 9783030933890
The Pine Genomes
The Pine Genomes, Springer International Publishing, pp.67-123, 2022, Compendium of Plant Genomes, 978-3-030-93390-6. ⟨10.1007/978-3-030-93390-6_5⟩
Compendium of Plant Genomes
Compendium of Plant Genomes-The Pine Genomes

International audience; The advent of next-generation genome sequencing technologies has allowed approaching the sequencing and analysis of large and complex conifer genomes. Maritime pine (Pinus pinaster Ait.) is an economically and ecologically imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9346baa3a2034af754ab887032acc772

Allosteric deregulation of phenylalanine biosynthesis evolved with the emergence of vascular plants

Autor: Concepción Ávila, Francisco M. Cánovas, Jorge El-Azaz, Fernando de la Torre, Belén Barcelona

Phenylalanine (Phe) is the precursor of essential secondary products in plants. Here we show that a key, rate-limiting step in Phe biosynthesis, which is catalyzed by arogenate dehydratase (ADT), experienced allosteric de-regulation during evolution.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7c5ef3291bc99fff5c52da639bc1a7
https://doi.org/10.1101/834747

The arogenate dehydratase ADT2 is essential for seed development in Arabidopsis

Autor: Concepción Ávila, Jorge El-Azaz, Fernando de la Torre, Francisco M. Cánovas

Publikováno v: Plant and Cell Physiology.

Phenylalanine (Phe) biosynthesis in plants is a key process, as Phe serves as a precursor of proteins and phenylpropanoids. The prephenate pathway connects chorismate, the final product of the shikimate pathway, with the biosynthesis of Phe and tyros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d30dc73e304bfe99259794bc45bcafe
https://doi.org/10.1093/pcp/pcy200