Výsledky vyhledávání - "Jorge E. Hernández-González"

Akademický článek

A Computer-Aided Approach for the Discovery of D-Peptides as Inhibitors of SARS-CoV-2 Main Protease

Autor: Jorge E. Hernández González, Raphael J. Eberle, Dieter Willbold, Mônika A. Coronado

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2022)

The SARS-CoV-2 main protease, also known as 3-chymotrypsin-like protease (3CLpro), is a cysteine protease responsible for the cleavage of viral polyproteins pp1a and pp1ab, at least, at eleven conserved sites, which leads to the formation of mature n

Externí odkaz: https://doaj.org/article/f9d9a436e2124368a2e9742cfc9313f0

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Computational study on the allosteric mechanism of Leishmania major IF4E-1 by 4E-interacting protein-1: Unravelling the determinants of m7GTP cap recognition

Autor: Lilian Hernández-Alvarez, Alexandre Suman de Araujo, Fátima Pereira de Souza, Jorge Chahine, Jorge E. Hernández-González, Pedro Geraldo Pascutti, Antonio B. de Oliveira

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2027-2044 (2021)

Graphical abstract
Highlights • Atomistic details on perturbations induced by Lm4E-IP1 binding are described. • The modulation of LmIF4E-1 affinity for the cap is confirmed by energetic analyses. • Signaling paths between the allosteric an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ec726077f7b2f96ac3ceaabdc203d3

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In silico Evaluation of Cucurbit[6]uril as a Potential Detector for Cocaine and Its Adulterants Lidocaine, Caffeine, and Procaine

Autor: Vitor B. P. Leite, Aline Thaís Bruni, Caio Henrique Pinke Rodrigues, Natalia J. Pedrina, Jorge E. Hernández-González

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 32, Issue: 4, Pages: 800-810, Published: 29 MAR 2021
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Journal of the Brazilian Chemical Society v.32 n.4 2021
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Made available in DSpace on 2021-06-25T12:39:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01. Added 1 bitstream(s) on 2021-07-15T15:06:17Z : No. of bitstreams: 1 S0103-50532021000400800.pdf: 5035489 bytes, checksum: 680db78654a402895c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c046b4edaf6838ff6e034c2ad623ce
https://doi.org/10.21577/0103-5053.20200231

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Water Bridges Play a Key Role in Affinity and Selectivity for Malarial Protease Falcipain-2

Autor: Pedro Geraldo Pascutti, Vitor B. P. Leite, Jorge E. Hernández-González, Lilian Hernández Alvarez

Publikováno v: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2021-06-25T12:27:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-11-23 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3e2940d2386e21d7a8d0cecd09d0bf
https://pubmed.ncbi.nlm.nih.gov/32634311

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Disrupting a key hydrophobic pair in the oligomerization interface of the actinoporins impairs their pore-forming activity

Autor: María E. Lanio, Pedro A. Valiente, Uris Ros, Carlos Alvarez, Jorge E. Hernández-González, Haydee Mesa-Galloso, D. Peter Tieleman, Ana J. García-Sáez, Lohans Pedrera, Karelia H. Delgado-Magnero, Sheila Cabezas, Aracelys López-Castilla

Publikováno v: Protein Science. 26:550-565

Crystallographic data of the dimeric and octameric forms of fragaceatoxin C (FraC) suggested the key role of a small hydrophobic protein-protein interaction surface for actinoporins oligomerization and pore formation in membranes. However, site-direc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c104cc1df377abfa53aef5262e917226
https://doi.org/10.1002/pro.3104

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A single P115Q mutation modulates specificity in the Corynebacterium pseudotuberculosis arginine repressor

Autor: Claudia M. A. Carareto, Ricardo Barros Mariutti, Jorge E. Hernández-González, Mariana Abrahão Bueno de Morais, Mário T. Murakami, Raghuvir K. Arni, A.F.Z. Nascimento

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2020-12-12T02:00:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-07-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The arginine repressor (ArgR) regulates the expression of genes involved in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c11fdc5c68721849a904ac7413ddbd3
https://doi.org/10.1016/j.bbagen.2020.129597

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Identification of (4-(9H-fluoren-9-yl) piperazin-1-yl) methanone derivatives as falcipain 2 inhibitors active against Plasmodium falciparum cultures

Autor: Pedro A. Valiente, Pedro Geraldo Pascutti, Luisa F. Hernández Ramírez, Diego E. Alvarez, Emir Salas-Sarduy, Jorge E. Hernández-González, Vitor B. P. Leite, María José Pascual, Adriana Pabón

Publikováno v: Repositorio UdeA
Universidad de Antioquia
instacron:Universidad de Antioquia

Background: Falcipain 2 (FP-2) is the hemoglobin-degrading cysteine protease of Plasmodium falciparum most extensively targeted to develop novel antimalarials. However, no commercial antimalarial drugs based on FP-2 inhibition are available yet due t

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Disrupting a key hydrophobic pair in the oligomerization interface of the actinoporins impairs their pore-forming activity

Autor: Haydeé, Mesa-Galloso, Karelia H, Delgado-Magnero, Sheila, Cabezas, Aracelys, López-Castilla, Jorge E, Hernández-González, Lohans, Pedrera, Carlos, Alvarez, D, Peter Tieleman, Ana J, García-Sáez, Maria E, Lanio, Uris, Ros, Pedro A, Valiente

Publikováno v: Protein science : a publication of the Protein Society. 26(3)

Crystallographic data of the dimeric and octameric forms of fragaceatoxin C (FraC) suggested the key role of a small hydrophobic protein–protein interaction surface for actinoporins oligomerization and pore formation in membranes. However, site‐d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8fce22855fa2ccf24ffd77f53cb56c37
https://pubmed.ncbi.nlm.nih.gov/28000294

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