Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Jorge E. Albina"'
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007212 (2018)
The innate immune system is responsible for many important functions in the body including responding to infection, clearing cancerous cells, healing wounds, and removing foreign substances. Although many of these functions happen simultaneously in l
Externí odkaz:
https://doaj.org/article/cca7dfb70c2240d8ae55c16e55cb22c8
Autor:
Meredith J Crane, Jean M Daley, Olivier van Houtte, Samielle K Brancato, William L Henry, Jorge E Albina
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86660 (2014)
The origin of wound repair macrophages is incompletely defined and was examined here in sterile wounds using the subcutaneous polyvinyl alcohol sponge implantation model in mice. Phenotypic analysis identified F4/80(+)Ly6C(hi)CD64(+)MerTK(-) monocyte
Externí odkaz:
https://doaj.org/article/e72814f47ae34c9197913c5f94d8d480
Pulmonary infection interrupts acute cutaneous wound healing through disruption of chemokine signals
Autor:
Sean F. Monaghan, William L. Henry, Lindsey Carlsen, Alexander R.D. Jordon, Amanda M. Jamieson, Yun Xu, Meredith J. Crane, Jorge E. Albina, Karisma R. P. Chhabria, Holly L. Tran, Benjamin M. Hall
SummaryStudies of the immune response typically focus on single-insult systems, with little known about how multi-insult encounters are managed. Pneumonia in patients recovering from surgery is a clinical situation that exemplifies the need for the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394b942de63417c0313db2bfe34a98b1
Publikováno v:
J Vis Exp
Wound healing is a complex process that requires the orderly progression of inflammation, granulation tissue formation, fibrosis, and resolution. Murine models provide valuable mechanistic insight into these processes; however, no single model fully
Autor:
Amanda M. Jamieson, William L. Henry, Jorge E. Albina, Yun Xu, Sean P. Gillis, Meredith J. Crane
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 8, p e1007212 (2018)
PLoS Pathogens, Vol 14, Iss 8, p e1007212 (2018)
The innate immune system is responsible for many important functions in the body including responding to infection, clearing cancerous cells, healing wounds, and removing foreign substances. Although many of these functions happen simultaneously in l
Autor:
Meredith Crane, Yun Xu, Sean F. Monaghan, Benjamin M. Hall, Holly L. Tran, William L Henry, Jorge E. Albina, Amanda M. Jamieson
Publikováno v:
The Journal of Immunology. 202:62.10-62.10
Hospitalized trauma patients have an increased risk of pulmonary infection. The acute response to injury, which relies on the coordinated activity of recruited leukocytes, may affect the early, innate immune-mediated control of lung infection. We hyp
Autor:
Meredith J. Crane, Samielle K. Brancato, Edmond Sabo, Jonathan S. Reichner, Jorge E. Albina, Alan A. Thomay, Jean M. Daley
Publikováno v:
Wound Repair and Regeneration. 21:624-633
The role of Toll-like receptor 4 (TLR4) in the regulation of inflammation and fibrosis in sterile wounds was investigated in TLR4 signal-deficient (C3H/HeJ or TLR4(-/-) ) and control mice using the subcutaneously implanted polyvinyl alcohol sponge wo
Autor:
Samielle K. Brancato, Jorge E. Albina
Publikováno v:
The American Journal of Pathology. 178:19-25
Recent results call for the reexamination of the phenotype of wound macrophages and their role in tissue repair. These results include the characterization of distinct circulating monocyte populations with temporally restricted capacities to migrate
Autor:
Mark W. Harty, Alan A. Thomay, Jonathan S. Reichner, Jean M. Daley, P.J. Worth, Leslie J. Shelton, Jorge E. Albina, Edmond Sabo
Publikováno v:
The American Journal of Pathology. 174:2129-2136
In this study, we investigated the role of interleukin (IL)-1 signaling in wound healing. IL-1 receptor type I (IL-1R) knockout (KO) mice showed reduced fibrosis in both cutaneous and deep tissue wounds, which was accompanied by a reduction in inflam
Autor:
Jonathan S. Reichner, Jorge E. Albina, X. Julia Xu, Balduino Mastrofrancesco, William L. Henry
Publikováno v:
The Journal of Immunology. 180:2125-2131
Macrophages activate the production of cytokines and chemokines in response to LPS through signaling cascades downstream from TLR4. Lipid mediators such as PGE2, which are produced during inflammatory responses, have been shown to suppress MyD88-depe