A cytoplasmic new catalytic subunit of calcineurin in Trypanosoma cruzi and its molecular and functional characterization.

Autor: Patricio R Orrego, Héctor Olivares, Esteban M Cordero, Albert Bressan, Mauro Cortez, Hernán Sagua, Ivan Neira, Jorge González, José Franco da Silveira, Nobuko Yoshida, Jorge E Araya

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 1, p e2676 (2014)

Parasitological cure for Chagas disease is considered extremely difficult to achieve because of the lack of effective chemotherapeutic agents against Trypanosoma cruzi at different stages of infection. There are currently only two drugs available. Th

Externí odkaz: https://doaj.org/article/97aa5ec72a5a4dec8bdd417995a58c16

Toxicological Characterization and Phospholipase D Activity of the Venom of the Spider Sicarius thomisoides

Autor: Tomás Arán-Sekul, Ivanka Perčić-Sarmiento, Verónica Valencia, Nelly Olivero, José M. Rojas, Jorge E. Araya, Andrés Taucare-Ríos, Alejandro Catalán

Publikováno v: Toxins, Vol 12, Iss 11, p 702 (2020)

Envenomation by Loxosceles spiders (Sicariidae family) has been thoroughly documented. However, little is known about the potential toxicity of members from the Sicarius genus. Only the venom of the Brazilian Sicarius ornatus spider has been toxicolo

Externí odkaz: https://doaj.org/article/1cb0ebf37d4d4cc5aaf9a997ec939dc6

Phospholipase D from Loxosceles laeta Spider Venom Induces IL-6, IL-8, CXCL1/GRO-α, and CCL2/MCP-1 Production in Human Skin Fibroblasts and Stimulates Monocytes Migration

Autor: José M. Rojas, Tomás Arán-Sekul, Emmanuel Cortés, Romina Jaldín, Kely Ordenes, Patricio R. Orrego, Jorge González, Jorge E. Araya, Alejandro Catalán

Publikováno v: Toxins, Vol 9, Iss 4, p 125 (2017)

Cutaneous loxoscelism envenomation by Loxosceles spiders is characterized by the development of a dermonecrotic lesion, strong inflammatory response, the production of pro-inflammatory mediators, and leukocyte migration to the bite site. The role of

Externí odkaz: https://doaj.org/article/733f1ff2c33a4c578c9e009a90faafa3

Effect of DODAB Nano-Sized Cationic Bilayer Fragments against

Autor: Thalita C S, Ferreira, Ismael P, Sauter, Lina, Borda-Samper, Enyd, Bentivoglio, Jarina P, DaMata, Noemi N, Taniwaki, Patrício R, Orrego, Jorge E, Araya, Nilton, Lincopan, Mauro, Cortez

Publikováno v: Molecules

The dioctadecyldimethylammonium bromide (DODAB) is a double-chained cationic lipid with potent bactericide and fungistatic activities; however, its toxicity on protozoan parasites is still unknown. Here, we show the antileishmanial activity of DODAB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::576c3291f02193bf14fef5473253349d
https://pubmed.ncbi.nlm.nih.gov/33291367

Haloterrigena sp. Strain SGH1, a Bacterioruberin-Rich, Perchlorate-Tolerant Halophilic Archaeon Isolated From Halite Microbial Communities, Atacama Desert, Chile

Autor: Jacek Wierzchos, Mauricio Venegas, Alexandra Galetović, Camila Salazar-Ardiles, Lidia M. Zuñiga, Jorge E. Araya, Francisca Fábrega, Nataly Flores, Carmen Ascaso, Virginia Souza-Egipsy, Benito Gómez-Silva, Bernardo Paredes, Sebastián Hoyos, Claudia Vilo, Ramón Alberto Batista-García

Publikováno v: Frontiers in Microbiology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Frontiers in Microbiology, Vol 11 (2020)

An extreme halophilic archaeon, strain SGH1, is a novel microorganism isolated from endolithic microbial communities colonizing halites at Salar Grande, Atacama Desert, in northern Chile. Our study provides structural, biochemical, genomic, and physi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81c7c1b7672daecec2ee0398f6fc632
http://hdl.handle.net/10261/232727