Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jorge Cebrián"'
Autor:
Jorge Cebrián, María-Luisa Martínez-Robles, Victor Martínez, Pablo Hernández, Dora B. Krimer, Jorge B. Schvartzman, María-José Fernández-Nestosa
Publikováno v:
DNA, Vol 4, Iss 2, Pp 170-179 (2024)
DNA knots are deleterious for living cells if not removed. Several theoretical and simulation approaches address the question of how topoisomerases select the intermolecular passages that preferentially lead to unknotting rather than to the knotting
Externí odkaz:
https://doaj.org/article/7ac973adfbe34014a1daff3d903d6857
Autor:
Jorge Cebrián, Victor Martínez, Pablo Hernández, Dora Krimer, María- Martínez-Robles, JORGE SCHVARTZMAN, María Jose Fernandez
Publikováno v:
Bio-Protocol, Vol 14, Iss 9 (2024)
Two-dimensional (2D) agarose gel electrophoresis is the method of choice to analyze DNA topology. The possibility to use E. coli strains with different genetic backgrounds in combination with nicking enzymes and different concentrations of norfloxaci
Externí odkaz:
https://doaj.org/article/7da02e98eae1494dbca313da4903254f
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302429 (2024)
Personality questionnaires stand as crucial instruments in personnel selection but their limitations turn the interest towards alternatives like game-related assessments (GRAs). GRAs developed for goals other than fun are called serious games. Within
Externí odkaz:
https://doaj.org/article/7f4541ecd4b84fd4827438e4afd109f9
Autor:
María Gallego-Delgado, Anabel Cámara-Checa, Marcos Rubio-Alarcón, David Heredero-Jung, Laura de la Fuente-Blanco, Josu Rapún, Beatriz Plata-Izquierdo, Sara Pérez-Martín, Jorge Cebrián, Lucía Moreno de Redrojo, Belén García-Berrocal, Eva Delpón, Pedro L. Sánchez, Eduardo Villacorta, Ricardo Caballero
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4686 (2024)
A novel rare mutation in the pore region of Nav1.5 channels (p.L889V) has been found in three unrelated Spanish families that produces quite diverse phenotypic manifestations (Brugada syndrome, conduction disease, dilated cardiomyopathy, sinus node d
Externí odkaz:
https://doaj.org/article/b6724659b6514b5fafe9879eddec1464
Autor:
Marcos Rubio-Alarcón, Anabel Cámara-Checa, María Dago, Teresa Crespo-García, Paloma Nieto-Marín, María Marín, José Luis Merino, Jorge Toquero, Rafael Salguero-Bodes, Juan Tamargo, Jorge Cebrián, Eva Delpón, Ricardo Caballero
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 13031 (2021)
The ZFHX3 and SCN5A genes encode the zinc finger homeobox 3 (Zfhx3) transcription factor (TF) and the human cardiac Na+ channel (Nav1.5), respectively. The effects of Zfhx3 on the expression of the Nav1.5 channel, and in cardiac excitability, are cur
Externí odkaz:
https://doaj.org/article/c86ad01495e945108f38d822939ffa96
Autor:
Jorge Cebrián, Victor Martínez, Pablo Hernández, Dora B. Krimer, María-José Fernández-Nestosa, Jorge B. Schvartzman
Publikováno v:
Biology, Vol 10, Iss 11, p 1195 (2021)
DNA topoisomerases are the enzymes that regulate DNA topology in all living cells. Since the discovery and purification of ω (omega), when the first were topoisomerase identified, the function of many topoisomerases has been examined. However, their
Externí odkaz:
https://doaj.org/article/f86df036de0b4fda942c8af1ffc489bc
Autor:
Jorge Cebrián, Estefanía Monturus, María-Luisa Martínez-Robles, Pablo Hernández, Dora B Krimer, Jorge B Schvartzman
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104995 (2014)
DNA topoisomerases are thought to play a critical role in transcription, replication and recombination as well as in the condensation and segregation of sister duplexes during cell division. Here, we used high-resolution two-dimensional agarose gel e
Externí odkaz:
https://doaj.org/article/e9af78d9c3a74107a3ce7277e9e8a4d3
Autor:
Anastasia Rastokina, Jorge Cebrián, Negin Mozafari, Nicholas H Mandel, C I Edvard Smith, Massimo Lopes, Rula Zain, Sergei M Mirkin
Publikováno v:
Nucleic Acids Research.
Friedreich's ataxia (FRDA) is caused by expansions of GAA•TTC repeats in the first intron of the human FXN gene that occur during both intergenerational transmissions and in somatic cells. Here we describe an experimental system to analyze large-sc
Autor:
Anabel Cámara-Checa, Francesca Perin, Marcos Rubio-Alarcón, María Dago, Teresa Crespo-García, Josu Rapún, María Marín, Jorge Cebrián, Francisco Bermúdez-Jiménez, Lorenzo Monserrat, Juan Tamargo, Ricardo Caballero, Juan Jiménez-Jáimez, Eva Delpón
BackgroundIn a family with inappropriate sinus tachycardia (IST) we identified a novel mutation (p.V240M) of the hyperpolarization-activated cyclic nucleotide-gated type 4 (HCN4) channel, which contributes to the pacemaker current (If) in human sinoa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d20eae379beb8ce872eb97b15fbf24f
https://doi.org/10.1101/2023.01.20.23284606
https://doi.org/10.1101/2023.01.20.23284606
Autor:
Teresa Crespo-García, Marcos Rubio-Alarcón, Anabel Cámara-Checa, María Dago, Josu Rapún, Paloma Nieto-Marín, María Marín, Jorge Cebrián, Juan Tamargo, Eva Delpón, Ricardo Caballero
Publikováno v:
Journal of General Physiology. 155
ATP-sensitive potassium (KATP) channels composed of Kir6.x and sulfonylurea receptor (SURs) subunits couple cellular metabolism to electrical activity. Cantú syndrome (CS) is a rare disease caused by mutations in the genes encoding Kir6.1 (KCNJ8) an