Výsledky vyhledávání - "Jorge Castro López"

Akademický článek

Cyclooxygenase-2 immunoexpression in intestinal epithelium and lamina propria of cats with inflammatory bowel disease and low grade alimentary lymphoma

Autor: Jorge Castro-López, Antonio Ramis, Marta Planellas, Mariana Teles, Josep Pastor

Publikováno v: BMC Veterinary Research, Vol 14, Iss 1, Pp 1-9 (2018)

Abstract Background Cyclooxygenase 2 (COX-2) is an inducible isoform by cellular activation, proinflammatory cytokines and growth factors. The aims of the current study were to evaluate COX-2 immunoexpression in epithelial and lamina propria (LP) of

Externí odkaz: https://doaj.org/article/8a6e3535b289437aa574e6a5f009a68a

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Akademický článek

Prevalence of selected infectious disease agents in stray cats in Catalonia, Spain

Autor: Sara Ravicini, Josep Pastor, Jennifer Hawley, Melissa Brewer, Jorge Castro-López, Melissa Beall, Michael R Lappin

Publikováno v: Journal of Feline Medicine and Surgery Open Reports, Vol 2 (2016)

Objectives The objective of the current study was to investigate the prevalence rates of the following infectious agents in 116 stray cats in the Barcelona area of Spain: Anaplasma phagocytophilum, Bartonella species, Borrelia burgdorferi, Chlamydia

Externí odkaz: https://doaj.org/article/bd0e9e16b57a453e8bc6724cd4c97157

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Synthesis, conformational analysis and

Autor: Iris A, Bermejo, Claudio D, Navo, Jorge, Castro-López, Ana, Guerreiro, Ester, Jiménez-Moreno, Elena M, Sánchez Fernández, Fayna, García-Martín, Hiroshi, Hinou, Shin-Ichiro, Nishimura, José M, García Fernández, Carmen Ortiz, Mellet, Alberto, Avenoza, Jesús H, Busto, Gonçalo J L, Bernardes, Ramón, Hurtado-Guerrero, Jesús M, Peregrina, Francisco, Corzana

Publikováno v: Chemical Science

The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to their potential use as antica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4924fbca379c7a77b550232cbdf1127
https://pubmed.ncbi.nlm.nih.gov/34122869

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Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment

Autor: Jesús H. Busto, Iris A. Bermejo, Elena M. Sánchez Fernández, Francisco Corzana, Carmen Ortiz Mellet, Hiroshi Hinou, Ramon Hurtado-Guerrero, José M. García Fernández, Shin-Ichiro Nishimura, Alberto Avenoza, Jorge Castro-López, Jesús M. Peregrina, Gonçalo J. L. Bernardes, Fayna Garcia-Martin, Ester Jiménez-Moreno, Claudio D. Navo, Ana Guerreiro

Publikováno v: Bermejo, I A, Navo, C D, Castro-López, J, Guerreiro, A, Jiménez-Moreno, E, Fernández, E M S, García-Martín, F, Hinou, H, Nishimura, S-I, Fernández, J M G, Mellet, C O, Avenoza, A, Busto, J H, Bernardes, G J L, Hurtado-Guerrero, R, Peregrina, J M & Corzana, F 2020, ' Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp 2-iminosugar fragment ', Chemical Science, vol. 11, no. 15, pp. 3996-4006 . https://doi.org/10.1039/c9sc06334j
Digital.CSIC. Repositorio Institucional del CSIC
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idUS. Depósito de Investigación de la Universidad de Sevilla
RIUR. Repositorio Institucional de la Universidad de La Rioja
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
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This journal is © The Royal Society of Chemistry 2020. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d425b95d85347381933be4f1d2224897
https://curis.ku.dk/portal/da/publications/synthesis-conformational-analysis-and-in-vivo-assays-of-an-anticancer-vaccine-that-features-an-unnatural-antigen-based-on-an-sp2iminosugar-fragment(4b462479-354d-4598-a525-e622d8a47f80).html

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Pilot study: duodenal MDR1 and COX2 gene expression in cats with inflammatory bowel disease and low-grade alimentary lymphoma

Autor: Camino Fierro, Jorge Castro-López, Karin Allenspach, Marta Planellas, Mariana Teles, Josep Pastor

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Objectives Multidrug resistance 1 (MDR1) encodes a protein called P-glycoprotein (P-gp), which serves as an efflux pump membrane protein implicated in intestinal homeostasis and drug resistance. Cyclooxygenase-2 (COX2) is a key enzyme in the synthesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4b66e3161a9b832bc2f59faa078289
https://doi.org/10.1177/1098612x17730708

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Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage

Autor: Alberto Avenoza, Francisco Corzana, Ana Guerreiro, Ismael Compañón, Jesús M. Peregrina, Gonçalo J. L. Bernardes, Juan Luis Asensio, Margarita Escudero-Casao, Jorge Castro-López, Sergio Castillón, Jesús Jiménez-Barbero, Ramon Hurtado-Guerrero, Omar Boutureira, Gonzalo Jiménez-Osés, Roberto Fiammengo, Vincenzo Mangini, Jesús H. Busto

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
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Digital.CSIC. Repositorio Institucional del CSIC

GalNAc-glycopeptides derived from mucin MUC1 are an important class of tumor-associated antigens. α-O-glycosylation forces the peptide to adopt an extended conformation in solution, which is far from the structure observed in complexes with a model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7570a36acfb60260c7519e522383e7
http://zaguan.unizar.es/record/87684

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A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations

Autor: Lluís Raich, Jorge Castro-López, Vladimir S. Borodkin, Wenxia Fang, Ramon Hurtado-Guerrero, Daan M. F. van Aalten, Carme Rovira

Publikováno v: Journal of the American Chemical Society. 138:3325-3332

The conversion of glycoside hydrolases (GHs) into transglycosylases (TGs), i.e., from enzymes that hydrolyze carbohydrates to enzymes that synthesize them, represents a promising solution for the large-scale synthesis of complex carbohydrates for bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92266f91f24a492341cb7c114544438
https://doi.org/10.1021/jacs.5b10092

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Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition

Autor: Gonzalo Jiménez-Osés, Emilio J. Cocinero, Aran Insausti, Jesús Jiménez-Barbero, Ramon Hurtado-Guerrero, Francisco Corzana, Ismael Compañón, Imanol Usabiaga, Jorge Castro-López, Juan Luis Asensio, José A. Fernández, Jesús M. Peregrina, Jesús H. Busto, Iris A. Bermejo, Alberto Avenoza

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
RIUR. Repositorio Institucional de la Universidad de La Rioja

The tumor-associated carbohydrate Tn antigens include two variants, αGalNAc-O-Thr and αGalNAc-O-Ser. In solution, they exhibit dissimilar shapes and dynamics and bind differently to the same protein receptor. Here, we demonstrate experimentally and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f53f91ed677ca838efd3548fd05e87d
https://investigacion.unirioja.es/documentos/5cf120f32999525b985d025e

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