Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jorge Capdevila"'
Autor:
Ankit Gilani, Varunkumar Pandey, Joseph Zullo, Priyanka Mishra, John R Falck, Jorge Capdevila, Michal Schwartzman
Publikováno v:
Hypertension. 66
20-HETE (20-Hydroxyeicosatetraenoic acid), is a cytochrome P450 (CYP) 4A-derived arachidonic acid metabolite. 20-HETE has been linked to both pro-hypertensive (via increased vasoconstriction, vascular remodeling and vascular injury of renal microvess
Publikováno v:
Hypertension. 64
Previous study demonstrated that the down-regulation of epoxygenase caused salt-sensitive hypertension. We used the real-time PCR technique to demonstrate that a high Na (4% Na) intake increased the Cyp2c44 expression in the thick ascending limb and
Autor:
Gregory Joseph, Victor Garcia, Elisabeth Steadman, Yan Ding, Brian Shkolnik, Jorge Capdevila, John R Falck, Kenneth E Bernstein, Michal L Schwartzman
Publikováno v:
Hypertension. 64
20-HETE-mediated hypertension in rats and mice is associated with increased vascular ACE expression and Ang II levels. We examined the contribution of vascular ACE to blood pressure (BP) and vascular remodeling in 20-HETE-dependent hypertension. The
Autor:
Pengcheng Luo, Mahesha Gangadhariah, Shouzuo Wei, Jorge Capdevila, Nancy J Brown, Ambra Pozzi, James M Luther
Publikováno v:
Hypertension. 62
Epoxyeicosatrienoic acids (EETs) are products of CYP450 epoxygenase and are degraded to DHETs by soluble epoxide hydrolase (sEH). Their natriuretic and vasodilatory actions oppose those of mineralocorticoids, but the effect of aldosterone on EET meta
Autor:
Gregory Joseph, Yan Ding, Victor Garcia, Elisabeth Steadman, Jorge Capdevila, John R Falck, Stephen Peterson, Michal L Schwartzman
Publikováno v:
Hypertension. 62
20-Hydroxyeicosatetraenoic acid (20-HETE) is a microcirculatory cytochrome P450-derived eicosanoid shown to increase smooth muscle contractions and proliferation, stimulate endothelial dysfunction and activation, and promotes hypertension. We develop
Publikováno v:
Hypertension. 60
Previous studies demonstrated that high K (HK) intake caused hypertension in Cyp2c44 (-/-) mice. In the present study we examined the role of Cyp2c44 in the collecting duct (CD) in blood pressure (BP) regulation during increased K intake in a CYP2c44
Autor:
Yan Ding, Cheng-Chia Wu, Victor Garcia, Irina Dimitrova, Adam Weidenhammer, Frank Zhang, John R Falck, Shaojun Mei, Jorge Capdevila, Michal L Schwartzman
Publikováno v:
Hypertension. 60
20-Hydroxyeicosatetraenoic acid (20-HETE) promotes smooth muscle contraction and proliferation, endothelial dysfunction and activation and hypertension. We have previously demonstrated that 20-HETE mediates androgen-induced hypertension. This study e
Publikováno v:
Biochemical Pharmacology. 30:843-848
In the presence of liver microsomes from phenobarbital-pretreated rats, hydrogen peroxide oxidized benzo [a]pyrene to a number of biologically significant products at a rate that was approximately 20 per cent as fast as that seen by us and others wit
Autor:
Elvira Ballester, Jorge Capdevila, Ricardo B. Maccioni, Alvaro Ramírez, María Luisa Dinamarga, Eugenia Del Villar
Publikováno v:
International Journal of Biochemistry. 6:405-412
1. 1. The phospholipoprotein nature of DDT-dehydrochlorinase (DDTase) purified from a DDT-resistant strain of houseflies has been made evident by isolation of the phospholipids by extraction of the enzyme with organic solvents and by gel filtration o
Publikováno v:
Biochemical and Biophysical Research Communications. 82:518-525
Analysis of repetitive scan difference spectra of incubation mixtures containing rat liver microsomes, 3- or 9-hydroxybenzo(a)pyrene, oxygen, and NADPH shows the formation of products with absorbance in the 400–450 nm region. Based on the chromatog