IL-17-high asthma with features of a psoriasis immunophenotype

Autor: Jörgen Östling, Marleen van Geest, James P.R. Schofield, Zala Jevnikar, Susan Wilson, Jonathan Ward, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Sven-Erik Dahlen, Stephen J. Fowler, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Ana R. Sousa, Yike Guo, Ian M. Adcock, Peter Howarth, Kian Fan Chung, Jeanette Bigler, Peter J. Sterk, Paul J. Skipp, Ratko Djukanović, Outi Vaarala, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, A.T. Bansal, F. Baribaud, S. Bates, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, K.F. Chung, C.H. Compton, J. Corfield, A. D'Amico, S.E. Dahlen, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, Y. Guo, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, P. Howarth, A.J. James, R. Knowles, A.J. Knox, N. Krug, D. Lefaudeux, M.J. Loza, R. Lutter, A. Manta, S. Masefield, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, P. Montuschi, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, P. Powell, G. Praticò, M. Puig N. Rao, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson, Antonios Aliprantis, David Allen, Kjell Alving, P. Badorrek, David Balgoma, S. Ballereau, Clair Barber, Manohara Kanangana Batuwitage, A. Bautmans, A. Bedding, A.F. Behndig, Jorge Beleta, A. Berglind, A. Berton, Grazyna Bochenek, Armin Braun, D. Campagna, Leon Carayannopoulos, C. Casaulta, Romanas Chaleckis, B. Dahlén, imothy Davison, Jorge De Alba, Inge De Lepeleire, Tamara Dekker, Ingrid Delin, P. Dennison, Annemiek Dijkhuis, Paul Dodson, Aleksandra Draper, K. Dyson, Jessica Edwards, L. El Hadjam, Rosalia Emma, Magnus Ericsson, C. Faulenbach, Breda Flood, G. Galffy, Hector Gallart, D. Garissi, J. Gent, M. Gerhardsson de Verdier, D. Gibeon, Cristina Gomez, Kerry Gove, Neil Gozzard, E. Guillmant-Farry, E. Henriksson, Lorraine Hewitt, U. Hoda, Richard Hu, Sile Hu, X. Hu, E. Jeyasingham, K. Johnson, N. Jullian, Juliette Kamphuis, Erika J. Kennington, Dyson Kerry, G. Kerry, M. Klüglich, Hugo Knobel, Johan Kolmert, J.R. Konradsen, Maxim Kots, Kosmas Kretsos, L. Krueger, Scott Kuo, Maciej Kupczyk, Bart Lambrecht, A.-S. Lantz, Christopher Larminie, L.X. Larsson, P. Latzin, N. Lazarinis, N. Lemonnier, Saeeda Lone-Latif, L.A. Lowe, Alexander Manta, Lisa Marouzet, Jane Martin, Caroline Mathon, L. McEvoy, Sally Meah, A. Menzies-Gow, Leanne Metcalf, Maria Mikus, Philip Monk, Shama Naz, K. Nething, Ben Nicholas, U. Nihlén, Peter Nilsson, R. Niven, B. Nordlund, S. Nsubuga, Antonio Pacino, Susanna Palkonen, J. Pellet, Giorgio Pennazza, Anne Petrén, Sandy Pink, C. Pison, Anthony Postle, Malayka Rahman-Amin, Lara Ravanetti, Emma Ray, Stacey Reinke, Leanne Reynolds, K. Riemann, Martine Robberechts, J.P. Rocha, C. Rossios, Kirsty Russell, Michael Rutgers, G. Santini, Marco Santoninco, M. Saqi, Corinna Schoelch, S. Scott, N. Sehgal, Marcus Sjödin, Barbara Smids, Caroline Smith, Jessica Smith, Katherine M. Smith, P. Söderman, A. Sogbessan, F. Spycher, Doroteya Staykova, S. Stephan, J. Stokholm, K. Strandberg, M. Sunther, M. Szentkereszty, L. Tamasi, K. Tariq, John-Olof Thörngren, Jonathan Thorsen, S. Valente, Marianne van de Pol, C.M. van Drunen, Jonathan Van Eyll, Jenny Versnel, Anton Vink, C. von Garnier, A. Vyas, Frans Wald, Samantha Walker, Kristiane Wetzel, Coen Wiegman, Siân Williams, Xian Yang, Elizabeth Yeyasingham, W. Yu Amgen, W. Zetterquist, Z. Zolkipli, A.H. Zwinderman

Publikováno v: Journal of Allergy and Clinical Immunology, 144(5), 1198-1213. Mosby Inc.
U-BIOPRED Study Group 2019, ' IL-17-high asthma with features of a psoriasis immunophenotype ', The Journal of allergy and clinical immunology . https://doi.org/10.1016/j.jaci.2019.03.027
Journal of allergy and clinical immunology, 144(5), 1198-1213. Mosby Inc.
Östling, J R, van Geest, M, U-BIOPRED Study Group, Schofield, J P R, Jevnikar, Z, Wilson, S, Ward, J, Lutter, R, Shaw, D E, Bakke, P S, Caruso, M, Dahlen, S-E, Fowler, S J, Horváth, I, Krug, N, Montuschi, P, Sanak, M, Sandström, T, Sun, K, Pandis, I, Auffray, C, Sousa, A R, Guo, Y, Adcock, I M, Howarth, P, Chung, K F, Bigler, J, Sterk, P J, Skipp, P J, Djukanović, R & Vaarala, O 2019, ' IL-17–high asthma with features of a psoriasis immunophenotype ', Journal of Allergy and Clinical Immunology, vol. 144, no. 5, pp. 1198-1213 . https://doi.org/10.1016/j.jaci.2019.03.027

Background The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required. Objective We sought to undertake a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924ef083d27395d6795993c461f0cec8
https://publica.fraunhofer.de/handle/publica/259279

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum -omics

Autor: Hugo H. Knobel, Koos Zwinderman, Anton Vink, Laurie Pahus, Elisabeth H. Bel, Wim van Aalderenm, Massimo Caruso, Marianne A. van de Pol, Lorraine Hewitt, David Balgoma, Jilaiha Gent, Paul Skipp, Sally Meah, Grazyna Bochenek, Martina Gahlemann, Xugang Hu, Graham Roberts, Stephen J. Fowler, Aleksandra Draper, Jon R Konradsen, Craig E. Wheelock, Philips Monk, Roelinde Middelveld, Päivi Söderman, Stelios Pavlidis, João P. Carvalho da Purfição Rocha, Caroline Smith, Alan J. Knox, Doroteya Staykova, Ildiko Horvath, Nadia Mores, Christophe von Garnier, Frans Wald, Uruj Hoda, Giuseppe Santini, Anne Petrén, Thomas Sandström, Alexander Mazein, Tamara Dekker, Ana R. Sousa, Andrea Maiser, Zsoka Weiszhart, Wolfgang Seibold, Susanna Palkonnen, Johan Kolmert, Cristina Gómez, Marco Sentoninco, Nancy Peffer, Anna James, Ingrid Delin, Montse Miralpeix, Antonios Aliprantis, Annemiek Dijkhuis, Amanda Roberts, Clare S. Murray, Lara Ravanetti, Yike Guo, Jenny Versnel, Richard Hu, Saeeda Lone-Satif, Jonathan Ward, Martine Robberechts, René Lutter, Linn Krueger, Antonio Pacino, Arnaldo D'Amico, Jans Hohlfeld, Scott Wagers, Neil Fitch, Pippa Powel, Matthew J. Loza, Karin Strandberg, Damijan Erzen, H. Ahmed, Per Bakke, Neil Gozzard, David Gibeon, Arianne Wagerner, Kerry Gove, Siân Williams, Ann Berglind, Rosalia Emma, Bob Thornton, Val Hudson, Elizabeth Yeyashingham, John Haughney, Ann-Sofie Lantz, Kjell Alving, Bart N. Lambrecht, Marek Sanak, Lilla Tamasi, Nadja Hawwa Vissing, Katja Nething, Barbro Dahlén, Jacek Musiał, Pim de Boer, Marcus O.D. Sjödin, Sarah Masefield, Marleen van Geest, Maciej Kupczyk, Peter H. Howarth, Alix Berton, Peter J. Sterk, David Myles, Peter Nilsson, Emma Ray, Ian M. Adcock, Pascal Chanez, Christos Rossios, Paolo Montuschi, Inge De Lepeleire, Armin Braun, Juliette Kamphuis, Davide Campagna, Salvatore Valente, Kees van Drunen, Urs Frey, Philipp Badorek, Ralf Sigmund, Malayka Rahman-Amin, Maria Mikus, James P.R. Schofield, Simone Hashimoto, Marton Szentkereszty, Gabriella Galffy, Lisa Marouzet, Barbara Smids, L. Larsson, Louise Fleming, Corinna Schoelch, Leanne Metcalf, Ashley Woosdcock, Anthony D. Postle, Maxim Kots, Sven-Erik Dahlén, J. M. Edwards, J.C. Smith, Gunilla Hedlin, Breda Flood, Veit J. Erpenbeck, Wen Yu, Susan J. Wilson, Jeanette Bigler, Jorge De Alba, Leon Carayannopoulos, Kristiane Wetzel, Klaus Fichtner, Paul Brinkman, Cecile T.J. Holweg, David Supple, Romanas Chaleckis, Coen Wiegman, Anthony Rowe, Hans Bisgaard, Annelie F. Behndig, Joost Brandsma, Richard G. Knowles, Jorge Beleta, Scott Kuo, Katherine M. Smith, Sandy Pink, Pieter-Paul Hekking, An Bautmans, Ben Nicholas, Kathrin Riemann, Michael Rutgers, Leanne Reynolds, Adesimbo Sogbesan, Dominic Burg, Aruna T. Bansal, Ulf Nihlen, Dyson Kerry, Ioannis Pandis, Julie Corfield, Björn Nordlund, Shama Naz, Wilhelm Zetterquist, Diane Lefaudeux, Xian Yang, Clair Barber, Kirsty E. Russell, Andrew Menzies-Gow, Dominic E. Shaw, Patrick Dennison, Elisabeth Henriksson, John G. Matthews, Tim Higgenbottam, Ratko Djukanovic, Charles Auffray, Kai Sun, Amphun Chaiboonchoe, Jonathan Thorsen, Nikos Lazarinis, Samantha Walker, John-Olof Thörngren, Frédéric Baribaud, Florian Singer, Klaus Bøonnelykke, John H. Riley, Magnus Ericsson, Sile Hu, Jørgen Vestbo, Bertrand De Meulder, Kamran Tariq, Maria Gerhardsson de Verdier, Stacey N. Reinke, Navin Rao, Trevor Garret, Norbert Krug, Michael Boedigheimer, Chris Compton, Cornelia Faulenbach, Hector Gallart, Matthias Klüglich, Caroline Mathon, Giorgio Pennazza, Kian Fan Chung, Thomas Geiser, Jörgen Östling, Courtney Coleman, Erika Kennington, Nora Adriaens, Jane Martin

Publikováno v: Journal of allergy and clinical immunology, 139(6), 1797-1807. Mosby Inc.
Lefaudeux, D, De Meulder, B, Loza, M J, Peffer, N, Rowe, A, Baribaud, F, Bansal, A T, Lutter, R, Sousa, A R, Corfield, J, Pandis, I, Bakke, P S, Caruso, M, Chanez, P, Dahlén, S-E, Fleming, L J, Fowler, S, Horvath, I, Krug, N, Montuschi, P, Sanak, M, Sandstrom, T, Shaw, D E, Singer, F, Sterk, P J, Roberts, G, Adcock, I M, Djukanovic, R, Auffray, C, Chung, K F & U-BIOPRED Study Group 2017, ' U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics ', Journal of Allergy and Clinical Immunology, vol. 139, no. 6, pp. 1797 . https://doi.org/10.1016/j.jaci.2016.08.048, https://doi.org/10.1016/j.jaci.2016.08.048

BACKGROUND: Asthma is a heterogeneous disease in which there is a differential response to asthma treatments. This heterogeneity needs to be evaluated so that a personalised management approach can be provided.OBJECTIVES: We stratified patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceb05fd5f8f224a60a64676698b62ac
https://ruj.uj.edu.pl/xmlui/handle/item/138911

Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile

Autor: Amadeu Gavaldà, Jesús Llenas, Jordi Gras, Jorge Beleta, Jordi Aubets, Josep Llupià

Publikováno v: Life Sciences. 90:301-305

Aclidinium bromide is a novel, long-acting, inhaled muscarinic antagonist currently in registration phase for the treatment of chronic obstructive pulmonary disease. Since urinary difficulty and retention have been reported for anticholinergic agents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eda5f2676f1a0807759961b9b1db5d7
https://doi.org/10.1016/j.lfs.2011.12.002

Synthesis and Biological Activity of Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines as Phosphodiesterase Type 4 Inhibitors

Autor: Jordi Serrat, Jordi Gràcia, Montserrat Miralpeix, Joan Taltavull, Lluís Pagès, Amadeu Gavaldà, Mònica Córdoba, Hamish Ryder, Miriam Andrés, Dolors Vilella, Jorge Beleta

Publikováno v: Journal of Medicinal Chemistry. 53:6912-6922

A series of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines (PTP) has been synthesized and tested as phosphodiesterase IV inhibitors (PDE4), a target for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Structure-activity relations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5284daedfa0c6d099cbc1182da52420e
https://doi.org/10.1021/jm100524j

A new chemical tool (C0036E08) supports the role of adenosine A2B receptors in mediating human mast cell activation

Autor: María Isabel Cadavid, Pedro Alvarez-Calderon, Montse Miralpeix, Jose-Luis Diaz, D. Alvarez, Marián Castro, Luis Valdés, Eduardo Domínguez, Montserrat Buceta, José Brea, Jorge Beleta, Fernando Domínguez, Javier Barcala, María Isabel Loza, Bernat Vidal

Publikováno v: Biochemical Pharmacology. 76:912-921

Asthma is a chronic inflammatory disease of the airways that involves many cell types, amongst which mast cells are known to be important. Adenosine, a potent bronchoconstricting agent, exerts its ability to modulate adenosine receptors of mast cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf033d83736073f53b5c9c3dd837216c
https://doi.org/10.1016/j.bcp.2008.07.011