Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jorge B, Schvartzman"'
Autor:
Jorge Cebrián, María-Luisa Martínez-Robles, Victor Martínez, Pablo Hernández, Dora B. Krimer, Jorge B. Schvartzman, María-José Fernández-Nestosa
Publikováno v:
DNA, Vol 4, Iss 2, Pp 170-179 (2024)
DNA knots are deleterious for living cells if not removed. Several theoretical and simulation approaches address the question of how topoisomerases select the intermolecular passages that preferentially lead to unknotting rather than to the knotting
Externí odkaz:
https://doaj.org/article/7ac973adfbe34014a1daff3d903d6857
Autor:
Jorge Cebrián, Victor Martínez, Pablo Hernández, Dora B. Krimer, María-José Fernández-Nestosa, Jorge B. Schvartzman
Publikováno v:
Biology, Vol 10, Iss 11, p 1195 (2021)
DNA topoisomerases are the enzymes that regulate DNA topology in all living cells. Since the discovery and purification of ω (omega), when the first were topoisomerase identified, the function of many topoisomerases has been examined. However, their
Externí odkaz:
https://doaj.org/article/f86df036de0b4fda942c8af1ffc489bc
Autor:
Vanessa Fernández-Calleja, María-José Fernández-Nestosa, Pablo Hernández, Jorge B. Schvartzman, Dora B. Krimer
Publikováno v:
PeerJ, Vol 7, p e6284 (2019)
Wiskott-Aldrich syndrome (WAS) is a recessive X-linked inmmunodeficiency caused by loss-of-function mutations in the gene encoding the WAS protein (WASp). WASp plays an important role in the polymerization of the actin cytoskeleton in hematopoietic c
Externí odkaz:
https://doaj.org/article/e042f29497994390b7ccea724f19efca
Autor:
Vanessa Fernández-Calleja, Pablo Hernández, Jorge B. Schvartzman, Mario García de Lacoba, Dora B. Krimer
Publikováno v:
PeerJ, Vol 5, p e3432 (2017)
Development of drug resistance limits the effectiveness of anticancer treatments. Understanding the molecular mechanisms triggering this event in tumor cells may lead to improved therapeutic strategies. Here we used RNA-seq to compare the transcripto
Externí odkaz:
https://doaj.org/article/e5bdfcc15a7e4ef0a682e358c2a1e826
Autor:
Alicia Castán, Vanessa Fernández-Calleja, Pablo Hernández, Dora B Krimer, Jorge B Schvartzman, María-José Fernández-Nestosa
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188172 (2017)
Simian Virus 40 (SV40) and Epstein-Barr Virus (EBV) are frequently used as model systems to study DNA replication. Their genomes are both circular duplex DNAs organized in a single replicon where replication initiates at a precise site upon binding o
Externí odkaz:
https://doaj.org/article/63507214f71b461a94390b87d4a593e7
Autor:
Jorge Cebrián, Estefanía Monturus, María-Luisa Martínez-Robles, Pablo Hernández, Dora B Krimer, Jorge B Schvartzman
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104995 (2014)
DNA topoisomerases are thought to play a critical role in transcription, replication and recombination as well as in the condensation and segregation of sister duplexes during cell division. Here, we used high-resolution two-dimensional agarose gel e
Externí odkaz:
https://doaj.org/article/e9af78d9c3a74107a3ce7277e9e8a4d3
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1703
Two-dimensional agarose gel electrophoresis is the method of choice to identify and quantify all the topological forms DNA molecules can adopt in vivo. Here we describe the materials and protocols needed to analyze catenanes, the natural outcome of D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31d2456507fa951ee94c998cede7701c
https://pubmed.ncbi.nlm.nih.gov/29177734
https://pubmed.ncbi.nlm.nih.gov/29177734
Development of drug resistance limits the effectiveness of anticancer treatments. Understanding the molecular mechanisms triggering this event in tumor cells may lead to improved therapeutic strategies. Here we used RNA-seq to compare the transcripto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01eb6500623265e94d26177de576a8c1
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1054
Two-dimensional (2D) agarose gel electrophoresis is nowadays one of the best methods available to analyze DNA molecules with different masses and shapes. The possibility to use nicking enzymes and intercalating agents to change the twist of DNA durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3258b883a7e6c6696efe35b8593e580
https://pubmed.ncbi.nlm.nih.gov/23913288
https://pubmed.ncbi.nlm.nih.gov/23913288
Autor:
Cebrián, Jorge, Martínez-Robles, María-Luisa, Martínez, Victor, Hernández, Pablo, Krimer, Dora B., Schvartzman, Jorge B., Fernández-Nestosa, María-José
Publikováno v:
DNA (2673-8856); Jun2024, Vol. 4 Issue 2, p170-179, 10p