Obatoclax reduces cell viability of acute myeloid leukemia cell lines independently of their sensitivity to venetoclax

Autor: Keli Lima, Hugo Passos Vicari, Jorge Antonio Elias Godoy Carlos, Jean Carlos Lipreri da Silva, Lorena Lobo de Figueiredo-Pontes, Eduardo Magalhães Rego, João Agostinho Machado-Neto

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 44, Iss 1, Pp 124-127 (2022)

Externí odkaz: https://doaj.org/article/9add93d6a22542bfad2878660233069f

AD80, a multikinase inhibitor, exhibits antineoplastic effects in acute leukemia cellular models targeting the PI3K/STMN1 axis

Autor: Jorge Antonio Elias Godoy Carlos, Letícia V. Costa-Lotufo, Andrei Leitão, João Agostinho Machado-Neto, Keli Lima

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Despite the great advances in the understanding of the molecular basis of acute leukemia, very little of this knowledge has been translated into new therapies. Stathmin 1 (STMN1), a phosphoprotein that regulates microtubules dynamics, is highly expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad84036e7b6b55c8f3a42003571a0df
https://doi.org/10.1007/s10637-021-01066-w

Reversine exerts cytotoxic effects through multiple cell death mechanisms in acute lymphoblastic leukemia

Autor: Juan L Coelho-Silva, Letícia V. Costa-Lotufo, Keli Lima, Jorge Antonio Elias Godoy Carlos, Hugo Passos Vicari, Fabio Pires de Souza Santos, João Agostinho Machado-Neto, Fabiola Traina, Nelson Hamerschlak, Natália Cestari Moreno, Raquel M. Alves-Paiva

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Acute lymphoblastic leukemia (ALL) is an aggressive hematological cancer with limited therapeutic options for adult patients. Aurora kinases have drawn attention as potential targets in hematological neoplasms due to their high expression and biologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59def7ca701e5d17ed3b3ed5c5297c4d
https://doi.org/10.1007/s13402-020-00551-3

Obatoclax reduces cell viability of acute myeloid leukemia cell lines independently of their sensitivity to venetoclax

Autor: João Agostinho Machado-Neto, Jorge Antonio Elias Godoy Carlos, Eduardo Magalhães Rego, Hugo Passos Vicari, Lorena Lôbo de Figueiredo Pontes, Letícia V. Costa-Lotufo, C. Hirakata, Fabiola Traina, Jean Carlos Lipreri da Silva, Keli Lima

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e4a51b388ea95fd480bc88be42e596
https://pubmed.ncbi.nlm.nih.gov/33753045

Reversine exhibits antineoplastic activity in JAK2V617F-positive myeloproliferative neoplasms

Autor: Raquel M. Alves-Paiva, Jorge Antonio Elias Godoy Carlos, Fabiola Traina, Nelson Hamerschlak, Fabio Pires de Souza Santos, Letícia V. Costa-Lotufo, Keli Lima, Hugo Passos Vicari, João Agostinho Machado-Neto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)

JAK2/STAT signaling participates in the Ph-negative myeloproliferative neoplasms (MPN) pathophysiology and has been targeted by ruxolitinib, a JAK1/2 inhibitor. In the present study, the impact of ruxolitinib treatment on cytoskeleton-related genes e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ffb19c8f9e3f053112c650e114c4eb