In vitro and in vivo anti-inflammatory and anticoagulant activities of Myrciaria plinioides D. Legrand ethanol leaf extract

Autor: Bruna Caye, Walter O. Beys-da-Silva, Dalana Faleiro, Annyta Fernandes Frota, Márcia Inês Goettert, Diorge Jônatas Marmitt, Shanna Bitencourt, Débora Mara Kich, Sheila Mariele Immich, Stefan Laufer, Chistiane Oliveira Coura, Norma Maria Barros Benevides, Jorge Almeida Guimaraes, Markus Berger

Publikováno v: Inflammopharmacology. 30(2)

Myrciaria plinioides D. Legrand (Myrtaceae) is a native plant of Southern Brazil, which have potential in the food industry due to its edible fruits. Many plants belonging to this genus have been used for a variety of illnesses, including inflammator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e38bccc7c71686640fe79bdaa799a92
https://pubmed.ncbi.nlm.nih.gov/35165808

COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders

Autor: Larissa Daniele Bobermin, André Quincozes-Santos, Walter O. Beys-da-Silva, Rafael Lopes da Rosa, Markus Berger, Emanuela Fernanda Tureta, Jorge Almeida Guimaraes, Lucélia Santi

Publikováno v: Brain, Behavior, & Immunity-Health
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Brain, Behavior, & Immunity-Health, Vol 11, Iss, Pp 100196-(2021)

Coronavirus disease 2019 (COVID-19) was initially characterized due to its impacts on the respiratory system; however, many recent studies have indicated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly affects the brai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5c733a88876040900082e272862d1a
http://europepmc.org/articles/PMC7834441

Allosteric Changes of Thrombin Catalytic Site Induced by Interaction of Bothrojaracin with Anion-Binding Exosites I and II

Autor: Russolina B. Zingali, Anne Wisner, Robson Q. Monteiro, Jorge Almeida Guimaraes, Cassian Bon, Jurema G. Rapôso

Publikováno v: Biochemical and Biophysical Research Communications. 262:819-822

Bothrojaracin, a 27-kDa C-type lectin from Bothrops jararaca venom, is a selective and potent thrombin inhibitor (K(d) = 0.6 nM) which interacts with the two thrombin anion-binding exosites (I and II) but not with its catalytic site. In the present s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097b83bd5b142fc42dbd6bec0b3eb333
https://doi.org/10.1006/bbrc.1999.1297

cAMP Does Not Inhibit Convulxin-Induced Tyrosyl-Phosphorylation of Human Platelet Proteins, Including PLCγ2, But Completely Blocks the Integrin αIIbβ3-Dependent Dephosphorylation Step: Comparisons with RGDS Peptide, Cytochalasin D, and Phenylarsine Oxide

Autor: Ivo M.B. Francischetti, Célia R. Carlini, Jorge Almeida Guimaraes

Publikováno v: Archives of Biochemistry and Biophysics. 354:255-262

Convulxin (Cvx) isolated from Crotalus durissus terrificus venom, induces platelet aggregation, phospholipase C (PLC) activation, and tyrosyl-phosphorylation (PTP) of multiple proteins, including PLCgamma2 by a mechanism independent of integrin alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f6b58cc9da6a350988bcbd0c633195
https://doi.org/10.1006/abbi.1998.0637

Distinct bothrojaracin isoforms produced by individual jararaca (Bothrops jararaca) snakes

Autor: Célia R. Carlini, Robson Q. Monteiro, Cassian Bon, Jorge Almeida Guimaraes, Russolina B. Zingali

Publikováno v: Toxicon. 35:649-657

Bothrojaracin (apparent mol. wt 27,000) is a potent inhibitor of thrombin previously isolated from the venom of Bothrops jararaca. Several molecular variants (isoforms) have been identified in a pool of venom collected from a large number of animals.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b351afebe8efd15dad8336f614ceec
https://doi.org/10.1016/s0041-0101(96)00176-6