Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jorge Almagro"'
Autor:
Jorge Almagro, Hendrik A. Messal
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Volume imaging visualizes the three-dimensional (3D) complexity of tumors to unravel the dynamic crosstalk between cancer cells and the heterogeneous landscape of the tumor microenvironment (TME). Tissue clearing and intravital microscopy (IVM) const
Externí odkaz:
https://doaj.org/article/2eb3bdbd07a940e298cda198aa5afa08
Autor:
Omar M. Khan, Jorge Almagro, Jessica K. Nelson, Stuart Horswell, Vesela Encheva, Kripa S. Keyan, Bruce E. Clurman, Ambrosius P. Snijders, Axel Behrens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The tumor suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF) and itself a target for ubiquitylation. Here, the authors show that TRIP12 mediates branched K11-linked ubiquitylation of FBW7, to regulate its
Externí odkaz:
https://doaj.org/article/6e27448b8929476da30da600acc41eb2
Autor:
Antonio Tedeschi, Jorge Almagro, Matthew J. Renshaw, Hendrik A. Messal, Axel Behrens, Mark Petronczki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
In mammalian cell lines, Cep55 protein recruits the endosomal sorting complex required for transport (ESCRT) and promotes the completion of cell division. Here, the authors show that Cep55-knockout mice are viable and primary fibroblasts cultured in
Externí odkaz:
https://doaj.org/article/e2f8bae001274af3b17c7fac1e5e07b8
Autor:
Carlos Gomez-Diaz, Gustav Jonsson, Katrin Schodl, Luiza Deszcz, Annika Bestehorn, Kevin Eislmayr, Jorge Almagro, Anoop Kavirayani, Mayu Seida, Lilian M. Fennell, Astrid Hagelkruys, Pavel Kovarik, Josef M. Penninger, Fumiyo Ikeda
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103241- (2021)
Summary: The Linear Ubiquitin Chain Assembly Complex (LUBAC), composed of HOIP, HOIL-1L, and SHARPIN, promotes tumor necrosis factor (TNF)-dependent NF-κB signaling in diverse cell types. HOIL-1L contains an Npl4 Zinc Finger (NZF) domain that specif
Externí odkaz:
https://doaj.org/article/50f34cedbe9040a0b591ac5680f24ec3
Autor:
José González-Martínez, Andrzej W. Cwetsch, Diego Martínez-Alonso, Luis R. López-Sainz, Jorge Almagro, Anna Melati, Jesús Gómez, Manuel Pérez-Martínez, Diego Megías, Jasminka Boskovic, Javier Gilabert-Juan, Osvaldo Graña-Castro, Alessandra Pierani, Axel Behrens, Sagrario Ortega, Marcos Malumbres
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations in genes encoding proteins involved in centrosomal and chromosomal dynamics during mitosis. Detailed MCPH pathogenesis at the cellular level is still elusive, gi
Externí odkaz:
https://doaj.org/article/35053144b6b7492e9888936049f5061b
Autor:
José Ignacio Fortea, Marta Puerto, Carolina Fernández-Mena, Iris Asensio, María Arriba, Jorge Almagro, Juan Bañares, Cristina Ripoll, Rafael Bañares, Javier Vaquero
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233778 (2020)
The selection of the anesthetic regime is a crucial component in many experimental animal studies. In rodent models of liver disease, the combination of ketamine and diazepam (KD), generally by the intramuscular (i.m.) route, has traditionally been t
Externí odkaz:
https://doaj.org/article/67c76ebe7b9d4b1abe2470d79259fbf5
Autor:
Matthew B. Smith, Hugh Sparks, Jorge Almagro, Agathe Chaigne, Axel Behrens, Chris Dunsby, Guillaume Salbreux
Segmenting cells within cellular aggregates in 3D is a growing challenge in cell biology, due to improvements in capacity and accuracy of microscopy techniques. Here we describe a pipeline to segment images of cell aggregates in 3D. The pipeline comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e016d34f0c72a8dd448926181cd29028
https://doi.org/10.1101/2023.02.17.528925
https://doi.org/10.1101/2023.02.17.528925
Publikováno v:
Nature Reviews Cancer. 21:718-730
The visualization of whole organs and organisms through tissue clearing and fluorescence volumetric imaging has revolutionized the way we look at biological samples. Its application to solid tumours is changing our perception of tumour architecture,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d15623935d74a0e55fbc7a4e678b5950
https://doi.org/10.1038/s41568-021-00382-w
https://doi.org/10.1038/s41568-021-00382-w
Autor:
Kripa S. Keyan, Jorge Almagro, Bruce E. Clurman, Ambrosius P. Snijders, Stuart Horswell, Vesela Encheva, Jessica K. Nelson, Axel Behrens, Omar M. Khan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52317b9d43255e960ff3720013d3922f
https://doaj.org/article/6e27448b8929476da30da600acc41eb2
https://doaj.org/article/6e27448b8929476da30da600acc41eb2
The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the cancer cells, the host tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6a8f6724572cbea47121ef52f44524