Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jorge Alexander Pavon"'
Autor:
Laurence Whitty-Léveillé, Zachary L. VanAernum, Jorge Alexander Pavon, Christa Murphy, Katie Neal, William Forest, Xinliu Gao, Wendy Zhong, Douglas D. Richardson, Hillary A. Schuessler
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTTransition metals can be introduced in therapeutic protein drugs at various steps of the manufacturing process (e.g. manufacturing raw materials, formulation, storage), and can cause a variety of modifications on the protein. These modificati
Externí odkaz:
https://doaj.org/article/e85c42b380f64a3e848c113be5ed8715
Autor:
Jing Liao, Yan An, Xinliu Gao, Michael Swanson, Kirby Martinez-Fonts, Fengqiang Wang, Li Xiao, Vibha Jawa, Jorge Alexander Pavon, Simon Letarte, Douglas D. Richardson, Edward C. Sherer, Xuanwen Li
Publikováno v:
Biotechnology Progress
Host cell proteins (HCPs) are process‐related impurities derived from host organisms, which need to be controlled to ensure adequate product quality and safety. In this study, product quality attributes were tracked for several monoclonal antibodie
Autor:
Xuanwen Li, Xinliu Gao, Douglas D. Richardson, Kirby Martinez-Fonts, Michael Swanson, Edward C. Sherer, Jorge Alexander Pavon, Yan An, Jing Liao, Li Xiao, Vibha Jawa, Simon Letarte
Host cell proteins (HCPs) are process-related impurities derived from host organisms, which need to be controlled to ensure adequate product quality and safety. In this study, product quality attributes were tracked for several mAbs under the intende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00ca2cb7089cd2322274176145c66ba5
https://doi.org/10.1101/2020.09.17.302679
https://doi.org/10.1101/2020.09.17.302679
Autor:
Danielle Aldredge, Li Xiao, Yan-Hui Liu, Eugene Dank, Jia Zhao, Jorge Alexander Pavon, Xiaojuan Li, Alex Fridman
Publikováno v:
Analytical chemistry. 91(3)
Oxidation of tryptophan not only generates heterogeneity of a therapeutic monoclonal antibody (mAb) but also can be a potential critical quality attribute (CQA) of the product. In this study, mAbs A-C of IgG1 and IgG4 (immunoglobulin G, IgG) isotypes
Autor:
Xiaojuan Li, Steven Chico, Jason K. Cheung, Xiaoyu Yang, Soundara Soundararajan, Umesh Kishnani, Jorge Alexander Pavon, Daisy Richardson, Huijuan Li, Mohammed Shameem
Publikováno v:
Journal of Chromatography A. 1431:154-165
Analysis of oxidation of monoclonal antibodies (mAbs) in most cases relies on peptide mapping and LC-MS, which is time consuming and labor-intensive. A robust chromatography based method that is able to resolve and quantitate mAb oxidation variants d