Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jorge A. Marchand"'
Autor:
Hinako Kawabe, Christopher A. Thomas, Shuichi Hoshika, Myong-Jung Kim, Myong-Sang Kim, Logan Miessner, Nicholas Kaplan, Jonathan M. Craig, Jens H. Gundlach, Andrew H. Laszlo, Steven A. Benner, Jorge A. Marchand
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The 4-letter DNA alphabet (A, T, G, C) as found in Nature is an elegant, yet non-exhaustive solution to the problem of storage, transfer, and evolution of biological information. Here, we report on strategies for both writing and reading DNA
Externí odkaz:
https://doaj.org/article/089902ffac324fbb99cc17565a7c89f5
Autor:
Akos Nyerges, Svenja Vinke, Regan Flynn, Siân V. Owen, Eleanor A. Rand, Bogdan Budnik, Eric Keen, Kamesh Narasimhan, Jorge A. Marchand, Maximilien Baas-Thomas, Min Liu, Kangming Chen, Anush Chiappino-Pepe, Fangxiang Hu, Michael Baym, George M. Church
Publikováno v:
Nature
Engineering the genetic code of an organism has been proposed to provide a firewall from natural ecosystems by preventing viral infections and gene transfer(1–6). However, numerous viruses and mobile genetic elements encode parts of the translation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16978e171f4fe15ecd1990188a73d3f6
https://doi.org/10.1038/s41586-023-05824-z
https://doi.org/10.1038/s41586-023-05824-z
Autor:
Elijah N. Kissman, Monica E. Neugebauer, Kiera H. Sumida, Cameron V. Swenson, Nicholas A. Sambold, Jorge A. Marchand, Douglas C. Millar, Michelle C. Y. Chang
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Biocatalytic C–H activation has the potential to merge enzymatic and synthetic strategies for bond formation. Fe II /αKG-dependent halogenases are particularly distinguished for their ability both to control selective C–H activation as well as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10fbe06b7e82f793f735f4393b22584a
https://doi.org/10.1073/pnas.2214512120
https://doi.org/10.1073/pnas.2214512120
Autor:
Elijah N. Kissman, Monica E. Neugebauer, Kiera H. Sumida, Cameron V. Swenson, Nicholas A. Sambold, Jorge A. Marchand, Douglas C. Millar, Michelle C.Y. Chang
Biocatalytic C–H activation has the potential to merge enzymatic and synthetic strategies for bond formation. FeII/αKG-dependent halogenases are particularly distinguished for their ability both to control selective C-H activation as well as to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fa6afa78fe39ffebdeeeb9a3d194d1c
https://doi.org/10.1101/2022.08.04.502814
https://doi.org/10.1101/2022.08.04.502814
Autor:
Akos Nyerges, Svenja Vinke, Regan Flynn, Siân V. Owen, Eleanor A. Rand, Bogdan Budnik, Eric Keen, Kamesh Narasimhan, Jorge A. Marchand, Maximilien Baas-Thomas, Min Liu, Kangming Chen, Anush Chiappino-Pepe, Fangxiang Hu, Michael Baym, George M. Church
Removing cellular transfer RNAs (tRNAs), making their cognate codons unreadable, creates a genetic firewall that prevents viral replication and horizontal gene transfer. However, numerous viruses and mobile genetic elements encode parts of the transl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b42d01b8dfbf612c2ee22298ce48dc9
https://doi.org/10.1101/2022.07.08.499367
https://doi.org/10.1101/2022.07.08.499367
Autor:
Monica E, Neugebauer, Elijah N, Kissman, Jorge A, Marchand, Jeffrey G, Pelton, Nicholas A, Sambold, Douglas C, Millar, Michelle C Y, Chang
Publikováno v:
Nature chemical biology. 18(2)
Fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::048532b62eecf0abbd344acd204cf168
https://pubmed.ncbi.nlm.nih.gov/34937913
https://pubmed.ncbi.nlm.nih.gov/34937913
Autor:
Jorge A Marchand, Merrick Pierson Smela, Kamesh Narasimhan, Thomas H. H. Jordan, George M. Church
Publikováno v:
Nucleic Acids Research
T-box riboswitches constitute a large family of tRNA-binding leader sequences that play a central role in gene regulation in many gram-positive bacteria. Accurate inference of the tRNA binding to T-box riboswitches is critical to predict their cis-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958bdd64a56bef298bd0f50f30f2c7c4
https://pubmed.ncbi.nlm.nih.gov/32882008
https://pubmed.ncbi.nlm.nih.gov/32882008
Autor:
Denis Wirtz, Thomas Wen Tao Cheng, Pei Hsun Wu, Rong Li, Daniele M. Gilkes, Akshay Narkar, Jude M. Phillip, Meng-Horng Lee, Jorge A Marchand
Publikováno v:
Science Advances
Cancer cell population exhibits great cellular heterogeneity, and single-cell morphology encodes metastatic potential.
A central goal of precision medicine is to predict disease outcomes and design treatments based on multidimensional informatio
A central goal of precision medicine is to predict disease outcomes and design treatments based on multidimensional informatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99987b6abbd2182cdc74728bf9994358
https://doi.org/10.1126/sciadv.aaw6938
https://doi.org/10.1126/sciadv.aaw6938
Autor:
Jonathan L. McMurry, Jeffrey G. Pelton, Kiera H Sumida, Monica E. Neugebauer, Jorge A Marchand, Michelle C. Y. Chang
Publikováno v:
Nature chemical biology. 15(10)
The integration of synthetic and biological catalysis enables new approaches to the synthesis of small molecules by combining the high selectivity of enzymes with the reaction diversity offered by synthetic chemistry. While organohalogens are valued
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590c9556a534caf89382bf3243c868f0
https://pubmed.ncbi.nlm.nih.gov/31548692
https://pubmed.ncbi.nlm.nih.gov/31548692
Autor:
M. C. Ing, Jorge A Marchand, Monica E. Neugebauer, Jeffrey G. Pelton, C.-I. Lin, Michelle C. Y. Chang
Publikováno v:
Nature. 567(7748)
Living systems can generate an enormous range of cellular functions, from mechanical infrastructure and signalling networks to enzymatic catalysis and information storage, using a notably limited set of chemical functional groups. This observation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4931596699252973882c50bfb2c5f585
https://pubmed.ncbi.nlm.nih.gov/31181902
https://pubmed.ncbi.nlm.nih.gov/31181902