Zobrazeno 1 - 10
of 7 973
pro vyhledávání: '"Jorge, S."'
Autor:
Zimmermann, Johannes, Wiktorek, Dariusz, Meusburger, Thomas, Monge-Dalmau, Miquel, Fabregat, Antonio, Jarasch, Alexander, Schmidt, Günter, Reis-Filho, Jorge S., Simpson, T. Ian
As the number of scientific publications and preprints is growing exponentially, several attempts have been made to navigate this complex and increasingly detailed landscape. These have almost exclusively taken unsupervised approaches that fail to in
Externí odkaz:
http://arxiv.org/abs/2408.03339
Publikováno v:
Molecular Oncology, Vol 18, Iss 11, Pp 2607-2611 (2024)
The incorporation of novel therapeutic agents such as antibody‐drug conjugates, radio‐conjugates, T‐cell engagers, and chimeric antigen receptor cell therapies represents a paradigm shift in oncology. Cell‐surface target quantification, quant
Externí odkaz:
https://doaj.org/article/9d347ab686e440cd84951119568cca8f
Autor:
Chiara Maria Lavinia Loeffler, Omar S. M. El Nahhas, Hannah Sophie Muti, Zunamys I. Carrero, Tobias Seibel, Marko van Treeck, Didem Cifci, Marco Gustav, Kevin Bretz, Nadine T. Gaisa, Kjong-Van Lehmann, Alexandra Leary, Pier Selenica, Jorge S. Reis-Filho, Nadina Ortiz-Bruechle, Jakob Nikolas Kather
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Homologous recombination deficiency (HRD) is recognized as a pan-cancer predictive biomarker that potentially indicates who could benefit from treatment with PARP inhibitors (PARPi). Despite its clinical significance, HRD testing
Externí odkaz:
https://doaj.org/article/003303862b20434e84941368c6c014a7
Autor:
Manisha Jalan, Aman Sharma, Xin Pei, Nils Weinhold, Erika S. Buechelmaier, Yingjie Zhu, Sana Ahmed-Seghir, Abhirami Ratnakumar, Melody Di Bona, Niamh McDermott, Joan Gomez-Aguilar, Kyrie S. Anderson, Charlotte K. Y. Ng, Pier Selenica, Samuel F. Bakhoum, Jorge S. Reis-Filho, Nadeem Riaz, Simon N. Powell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Collisions of the transcription and replication machineries on the same DNA strand can pose a significant threat to genomic stability. These collisions occur in part due to the formation of RNA-DNA hybrids termed R-loops, in which a newly tr
Externí odkaz:
https://doaj.org/article/7cd61270c6534754a1bbd7203bce046c
Autor:
Nahhas, Omar S. M. El, Loeffler, Chiara M. L., Carrero, Zunamys I., van Treeck, Marko, Kolbinger, Fiona R., Hewitt, Katherine J., Muti, Hannah S., Graziani, Mara, Zeng, Qinghe, Calderaro, Julien, Ortiz-Brüchle, Nadina, Yuan, Tanwei, Hoffmeister, Michael, Brenner, Hermann, Brobeil, Alexander, Reis-Filho, Jorge S., Kather, Jakob Nikolas
Deep Learning (DL) can predict biomarkers from cancer histopathology. Several clinically approved applications use this technology. Most approaches, however, predict categorical labels, whereas biomarkers are often continuous measurements. We hypothe
Externí odkaz:
http://arxiv.org/abs/2304.05153
Autor:
Garcia, Jorge S., Ohsawa, Tomoki
Publikováno v:
Journal of Nonlinear Science, Volume 34, article number 91, (2024)
We extend the method of Controlled Lagrangians to nonholonomic Euler--Poincar\'e equations with advected parameters, specifically to those mechanical systems on Lie groups whose symmetry is broken not only by a potential force but also by nonholonomi
Externí odkaz:
http://arxiv.org/abs/2303.13086
Autor:
Yingjie Zhu, Xin Pei, Ardijana Novaj, Jeremy Setton, Daniel Bronder, Fatemeh Derakhshan, Pier Selenica, Niamh McDermott, Mehmet Orman, Sarina Plum, Shyamal Subramanyan, Sara H. Braverman, Biko McMillan, Sonali Sinha, Jennifer Ma, Andrea Gazzo, Atif Khan, Samuel Bakhoum, Simon N. Powell, Jorge S. Reis-Filho, Nadeem Riaz
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Pathogenic BRCA1 or BRCA2 germline mutations contribute to hereditary breast, ovarian, prostate, and pancreatic cancer. Paradoxically, bi-allelic inactivation of BRCA1 or BRCA2 (bBRCA1/2) is embryonically lethal and decreases cell
Externí odkaz:
https://doaj.org/article/a99e307f304a411b854e096a6e780f20
Autor:
Steffi Oesterreich, Leigh Pate, Adrian V. Lee, Fangyuan Chen, Rachel C. Jankowitz, Rita Mukhtar, Otto Metzger, Matthew J. Sikora, Christopher I. Li, Christos Sotiriou, Osama S. Shah, Thijs Koorman, Gary Ulaner, Jorge S. Reis-Filho, Nancy M. Davidson, Karen Van Baelen, Laurie Hutcheson, Siobhan Freeney, Flora Migyanka, Claire Turner, Patrick Derksen, Todd Bear, Christine Desmedt
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-7 (2024)
Abstract There is growing awareness of the unique etiology, biology, and clinical presentation of invasive lobular breast cancer (ILC), but additional research is needed to ensure translation of findings into management and treatment guidelines. We c
Externí odkaz:
https://doaj.org/article/674206de519c4c9a91765a34839d5098