Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Jorge, Moscat"'
Autor:
Anxo Martinez-Ordoñez, Hiroto Kinoshita, Tania Cid-Diaz, Angeles Duran, Marta Osrodek, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103303- (2024)
Summary: Applying Opal multiplex immunofluorescence (OMI) to characterize intestinal tissues of genetically engineered mouse models provides an excellent tool for studying complex processes. However, detecting appropriate signals from multiple target
Externí odkaz:
https://doaj.org/article/a7f238d9bb394ea9b94266059e852c5d
Autor:
Yu Muta, Juan F. Linares, Anxo Martinez-Ordoñez, Angeles Duran, Tania Cid-Diaz, Hiroto Kinoshita, Xiao Zhang, Qixiu Han, Yuki Nakanishi, Naoko Nakanishi, Thekla Cordes, Gurpreet K. Arora, Marc Ruiz-Martinez, Miguel Reina-Campos, Hiroaki Kasashima, Masakazu Yashiro, Kiyoshi Maeda, Ana Albaladejo-Gonzalez, Daniel Torres-Moreno, José García-Solano, Pablo Conesa-Zamora, Giorgio Inghirami, Christian M. Metallo, Timothy F. Osborne, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation and progression through the serrated route are largely unknown. Although relatively well characterized as BRAF mutant cancers, their po
Externí odkaz:
https://doaj.org/article/7936ce2ec8a04c66b79574c289fddb37
Autor:
Mayuki Omatsu, Yuki Nakanishi, Kosuke Iwane, Naoki Aoyama, Angeles Duran, Yu Muta, Anxo Martinez-Ordoñez, Qixiu Han, Nobukazu Agatsuma, Kenta Mizukoshi, Munenori Kawai, Go Yamakawa, Mio Namikawa, Kensuke Hamada, Yuichi Fukunaga, Takahiro Utsumi, Makoto Sono, Tomonori Masuda, Akitaka Hata, Osamu Araki, Munemasa Nagao, Takaaki Yoshikawa, Satoshi Ogawa, Yukiko Hiramatsu, Motoyuki Tsuda, Takahisa Maruno, Toshiaki Kogame, Hiroaki Kasashima, Nobuyuki Kakiuchi, Masahiro M. Nakagawa, Kenji Kawada, Masakazu Yashiro, Kiyoshi Maeda, Yasuyuki Saito, Takashi Matozaki, Akihisa Fukuda, Kenji Kabashima, Kazutaka Obama, Seishi Ogawa, Nader Sheibani, Maria T. Diaz-Meco, Jorge Moscat, Hiroshi Seno
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness of colorectal cancers (CRC), driving progression and metastasis. Targetable molecules in the tumor microenvironment
Externí odkaz:
https://doaj.org/article/faf191500a2f4f9e8f8e32b58ac4ba14
Autor:
Anxo Martinez-Ordoñez, Tania Cid-Diaz, Angeles Duran, Qixiu Han, Jorge Moscat, Maria T. Diaz-Meco
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102243- (2023)
Summary: Imaging organoid culture provides an excellent tool for studying complex diseases such as cancer. However, retaining the morphology of intact organoids for immunolabeling has been challenging. Here, we describe a protocol for immunofluoresce
Externí odkaz:
https://doaj.org/article/12e40ca87e424f45b1641e5dd9553d85
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101635- (2022)
Summary: Air-liquid organotypic culture models enable the study of the cellular crosstalk in the tumor microenvironment. This 3D assay recapitulates the tumor niche more faithfully than 2D culture systems and represents a versatile platform that can
Externí odkaz:
https://doaj.org/article/2f1b844e394e4772baeb0915e5d617a5
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ
Autor:
Jianfeng Huang, Juan F. Linares, Angeles Duran, Wenmin Xia, Alan R. Saltiel, Timo D. Müller, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
p62 is a signaling hub protein that contributes to the control of energy expenditure. Here the authors investigate the relative roles of p62 and a similar protein, NBR1, and show that NBR1 is required for the repression of thermogenesis in adipocytes
Externí odkaz:
https://doaj.org/article/1f44af61cd1540b195d9f442e64e2d81
Autor:
Katrin Fischer, Anna Fenzl, Dianxin Liu, Kenneth A. Dyar, Maximilian Kleinert, Markus Brielmeier, Christoffer Clemmensen, Anna Fedl, Brian Finan, Andre Gessner, Martin Jastroch, Jianfeng Huang, Susanne Keipert, Martin Klingenspor, Jens C. Brüning, Manfred Kneilling, Florian C. Maier, Ahmed E. Othman, Bernd J. Pichler, Ines Pramme-Steinwachs, Stephan Sachs, Angelika Scheideler, Wolfgang M. Thaiss, Henriette Uhlenhaut, Siegfried Ussar, Stephen C. Woods, Julia Zorn, Kerstin Stemmer, Sheila Collins, Maria Diaz-Meco, Jorge Moscat, Matthias H. Tschöp, Timo D. Müller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Beta-adrenergic stimulation of brown adipose tissue leads to thermogenesis via the activating transcription factor 2 (ATF2) mediated expression of the thermogenic genes Ucp1 and Pgc-1α. Here, the authors show that the scaffold protein p62 regulates
Externí odkaz:
https://doaj.org/article/f38460b423054ee680f7224c62a860c9
Autor:
Hiroaki Kasashima, Angeles Duran, Tania Cid-Diaz, Yu Muta, Hiroto Kinoshita, Eduard Batlle, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100297- (2021)
Summary: In vivo interrogation of the functional role of genes implicated in colorectal cancer (CRC) is limited by the need for physiological models that mimic the disease. Here, we describe a protocol that provides the steps required for the orthoto
Externí odkaz:
https://doaj.org/article/74501688acdc46989f1bbf4596c7544d
Autor:
Hiroaki Kasashima, Angeles Duran, Tania Cid-Diaz, Yotaro Kudo, Maria T. Diaz-Meco, Jorge Moscat
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100185- (2020)
Summary: This protocol provides the steps required for a mouse liver orthotopic implantation model. The reliable pre-clinical animal models that have similar characteristics to hepatocellular carcinoma (HCC) are a powerful tool to unveil the mechanis
Externí odkaz:
https://doaj.org/article/2e80bf2ebd594560aaadb1533afd5ce5
Publikováno v:
Trends in Cell Biology. 32:1023-1034
Nononcogenic cancer drivers often impinge on complex signals that create new addictions and vulnerabilities. Protein kinase Cλ/ι (PKCλ/ι) suppresses tumorigenesis by blocking metabolic pathways that regulate fuel oxidation and create building blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b721590888cd0ed3da2770be3618054
https://doi.org/10.1016/j.tcb.2022.04.002
https://doi.org/10.1016/j.tcb.2022.04.002