IRL201104, A Novel Immunomodulatory Peptide, Shows A Long Lasting Reduction In Anaphylaxis Symptoms And Allergy Biomarkers In A Murine Model Of Food Allergy

Autor: Jorge De Alba, Valerie Corrigall, Paul Eggleton, Roly Foulkes

Publikováno v: Journal of Allergy and Clinical Immunology. 151:AB228

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14a4df4ac6f858eb3f19c2b3dc656942
https://doi.org/10.1016/j.jaci.2022.12.710

Pharmacological Profile of AZD8871 (LAS191351), a Novel Inhaled Dual M3 Receptor Antagonist/β2-Adrenoceptor Agonist Molecule with Long-Lasting Effects and Favorable Safety Profile

Autor: Jorge De Alba, Carla Carcasona, Jose Luis Montero, Julio Cortijo, Carlos Puig, Jose Luis Ortiz, Dolors Vilella, Israel Ramos, Chris P. Doe, Montserrat Miralpeix, Mònica Aparici, Raquel Otal, Amadeu Gavaldà

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 370:127-136

AZD8871 is a novel muscarinic antagonist and β2-adrenoceptor agonist in development for chronic obstructive pulmonary disease. This study describes the pharmacological profile of AZD8871 in in vitro and in vivo assays. AZD8871 is potent at the human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c909b79679d9d13e2718a5ae0e2df9db
https://doi.org/10.1124/jpet.118.255620

IL-17-high asthma with features of a psoriasis immunophenotype

Autor: Jörgen Östling, Marleen van Geest, James P.R. Schofield, Zala Jevnikar, Susan Wilson, Jonathan Ward, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Sven-Erik Dahlen, Stephen J. Fowler, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Ana R. Sousa, Yike Guo, Ian M. Adcock, Peter Howarth, Kian Fan Chung, Jeanette Bigler, Peter J. Sterk, Paul J. Skipp, Ratko Djukanović, Outi Vaarala, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, A.T. Bansal, F. Baribaud, S. Bates, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, K.F. Chung, C.H. Compton, J. Corfield, A. D'Amico, S.E. Dahlen, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, Y. Guo, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, P. Howarth, A.J. James, R. Knowles, A.J. Knox, N. Krug, D. Lefaudeux, M.J. Loza, R. Lutter, A. Manta, S. Masefield, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, P. Montuschi, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, P. Powell, G. Praticò, M. Puig N. Rao, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson, Antonios Aliprantis, David Allen, Kjell Alving, P. Badorrek, David Balgoma, S. Ballereau, Clair Barber, Manohara Kanangana Batuwitage, A. Bautmans, A. Bedding, A.F. Behndig, Jorge Beleta, A. Berglind, A. Berton, Grazyna Bochenek, Armin Braun, D. Campagna, Leon Carayannopoulos, C. Casaulta, Romanas Chaleckis, B. Dahlén, imothy Davison, Jorge De Alba, Inge De Lepeleire, Tamara Dekker, Ingrid Delin, P. Dennison, Annemiek Dijkhuis, Paul Dodson, Aleksandra Draper, K. Dyson, Jessica Edwards, L. El Hadjam, Rosalia Emma, Magnus Ericsson, C. Faulenbach, Breda Flood, G. Galffy, Hector Gallart, D. Garissi, J. Gent, M. Gerhardsson de Verdier, D. Gibeon, Cristina Gomez, Kerry Gove, Neil Gozzard, E. Guillmant-Farry, E. Henriksson, Lorraine Hewitt, U. Hoda, Richard Hu, Sile Hu, X. Hu, E. Jeyasingham, K. Johnson, N. Jullian, Juliette Kamphuis, Erika J. Kennington, Dyson Kerry, G. Kerry, M. Klüglich, Hugo Knobel, Johan Kolmert, J.R. Konradsen, Maxim Kots, Kosmas Kretsos, L. Krueger, Scott Kuo, Maciej Kupczyk, Bart Lambrecht, A.-S. Lantz, Christopher Larminie, L.X. Larsson, P. Latzin, N. Lazarinis, N. Lemonnier, Saeeda Lone-Latif, L.A. Lowe, Alexander Manta, Lisa Marouzet, Jane Martin, Caroline Mathon, L. McEvoy, Sally Meah, A. Menzies-Gow, Leanne Metcalf, Maria Mikus, Philip Monk, Shama Naz, K. Nething, Ben Nicholas, U. Nihlén, Peter Nilsson, R. Niven, B. Nordlund, S. Nsubuga, Antonio Pacino, Susanna Palkonen, J. Pellet, Giorgio Pennazza, Anne Petrén, Sandy Pink, C. Pison, Anthony Postle, Malayka Rahman-Amin, Lara Ravanetti, Emma Ray, Stacey Reinke, Leanne Reynolds, K. Riemann, Martine Robberechts, J.P. Rocha, C. Rossios, Kirsty Russell, Michael Rutgers, G. Santini, Marco Santoninco, M. Saqi, Corinna Schoelch, S. Scott, N. Sehgal, Marcus Sjödin, Barbara Smids, Caroline Smith, Jessica Smith, Katherine M. Smith, P. Söderman, A. Sogbessan, F. Spycher, Doroteya Staykova, S. Stephan, J. Stokholm, K. Strandberg, M. Sunther, M. Szentkereszty, L. Tamasi, K. Tariq, John-Olof Thörngren, Jonathan Thorsen, S. Valente, Marianne van de Pol, C.M. van Drunen, Jonathan Van Eyll, Jenny Versnel, Anton Vink, C. von Garnier, A. Vyas, Frans Wald, Samantha Walker, Kristiane Wetzel, Coen Wiegman, Siân Williams, Xian Yang, Elizabeth Yeyasingham, W. Yu Amgen, W. Zetterquist, Z. Zolkipli, A.H. Zwinderman

Publikováno v: Journal of Allergy and Clinical Immunology, 144(5), 1198-1213. Mosby Inc.
U-BIOPRED Study Group 2019, ' IL-17-high asthma with features of a psoriasis immunophenotype ', The Journal of allergy and clinical immunology . https://doi.org/10.1016/j.jaci.2019.03.027
Journal of allergy and clinical immunology, 144(5), 1198-1213. Mosby Inc.
Östling, J R, van Geest, M, U-BIOPRED Study Group, Schofield, J P R, Jevnikar, Z, Wilson, S, Ward, J, Lutter, R, Shaw, D E, Bakke, P S, Caruso, M, Dahlen, S-E, Fowler, S J, Horváth, I, Krug, N, Montuschi, P, Sanak, M, Sandström, T, Sun, K, Pandis, I, Auffray, C, Sousa, A R, Guo, Y, Adcock, I M, Howarth, P, Chung, K F, Bigler, J, Sterk, P J, Skipp, P J, Djukanović, R & Vaarala, O 2019, ' IL-17–high asthma with features of a psoriasis immunophenotype ', Journal of Allergy and Clinical Immunology, vol. 144, no. 5, pp. 1198-1213 . https://doi.org/10.1016/j.jaci.2019.03.027

Background The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required. Objective We sought to undertake a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924ef083d27395d6795993c461f0cec8
https://publica.fraunhofer.de/handle/publica/259279

In vitro and in vivo preclinical profile of abediterol (LAS100977), an inhaled long-acting β2-adrenoceptor agonist, compared with indacaterol, olodaterol and vilanterol

Autor: Montserrat Miralpeix, Israel Ramos, Dolors Vilella, Jorge De Alba, Raquel Otal, Vicente Marco García, Rosa López, Amadeu Gavaldà, Carlos Puig, Carla Carcasona, Christopher Doe, Joan Antoni Fernandez-Blanco, Mònica Aparici, Jose Luis Montero

Publikováno v: European Journal of Pharmacology. 770:61-69

Abediterol is a novel long-acting β2-adrenoceptor agonist (LABA) currently in development for once-daily combination maintenance therapy of asthma and COPD. This study investigated the preclinical profile of abediterol in terms of affinity, potency,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b4c0bce1886e7d02854f8a57b0da44
https://doi.org/10.1016/j.ejphar.2015.11.053

Double-stranded RNA evokes exacerbation in a mouse model of corticosteroid refractory asthma

Autor: Neus Prats, Montserrat Miralpeix, Neil Gozzard, Jorge De Alba, Anna Domènech, Raquel Otal, Elena Calama

Publikováno v: Clinical Science. 129:973-987

RNA viruses are a major cause of respiratory infections and are known to exacerbate asthma and other respiratory diseases. Our aim was to test the ability of poly(I:C) (polyinosinic:polycytidylic acid), a viral surrogate, to elicit exacerbation in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6e7ff7914a237a259adfeabe0c6f35
https://doi.org/10.1042/cs20150292