Directed Mutational Strategies Reveal Drug Binding and Transport by the MDR Transporters of Candida albicans

Autor: Atanu Banerjee, Jorgaq Pata, Suman Sharma, Brian C. Monk, Pierre Falson, Rajendra Prasad

Publikováno v: Journal of Fungi, Vol 7, Iss 2, p 68 (2021)

Multidrug resistance (MDR) transporters belonging to either the ATP-Binding Cassette (ABC) or Major Facilitator Superfamily (MFS) groups are major determinants of clinical drug resistance in fungi. The overproduction of these proteins enables the ext

Externí odkaz: https://doaj.org/article/b28ca69cc127468a8cab342d5e97d76b

Production and Purification of a GFP-Tagged ABC Transporter CaCdr1p

Autor: Jorgaq Pata, Alexis Moreno, Sandrine Magnard, Atanu Banerjee, Rajendra Prasad, Pierre Falson

Publikováno v: Methods in Molecular Biology ISBN: 9781071623671

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbcb295b0f49c3b4b75aa0b381fc488f
https://doi.org/10.1007/978-1-0716-2368-8_9

ABCG: a new fold of ABC exporters and a whole new bag of riddles!

Autor: Jorgaq Pata, Atanu Banerjee, Alexis Moreno, Pierre Falson, Rajendra Prasad

Publikováno v: Advances in Protein Chemistry and Structural Biology ISBN: 9780128220870
Advances in Protein Chemistry and Structural Biology
Rossen Donev. Advances in Protein Chemistry and Structural Biology, 123, Elsevier, pp.163-191, 2021, ⟨10.1016/bs.apcsb.2020.09.006⟩

International audience; ATP-binding cassette (ABC) superfamily comprises membrane transporters that power the active transport of substrates across biological membranes. These proteins harness the energy of nucleotide binding and hydrolysis to fuel s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059c6d44f0146b51b3b8712673a72d85
https://doi.org/10.1016/bs.apcsb.2020.09.006

Cdr1p highlights the role of the non-hydrolytic ATP-binding site in driving drug translocation in asymmetric ABC pumps

Autor: Atanu Banerjee, Alexis Moreno, Alok K. Mondal, Suman Sharma, Jorgaq Pata, Cédric Orelle, Remya Nair, Mohammad Firoz Khan, Rajendra Prasad, Sobhan Sen, Pierre Falson

Publikováno v: Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2019, pp.183131. ⟨10.1016/j.bbamem.2019.183131⟩

ATP-binding cassette (ABC) transporters couple ATP binding and hydrolysis to the translocation of allocrites across membranes. Two shared nucleotide-binding sites (NBS) participate in this cycle. In asymmetric ABC pumps, only one of them hydrolyzes A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15714039dfe13f2dc2afe4ce6657ca0
https://pubmed.ncbi.nlm.nih.gov/31734312