Výsledky vyhledávání - "Jorg-Peter Kleim"

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants

Autor: Y. Hsiou, Reinhard Kirsch, Irvin Winkler, Gunther Riess, Manfred Rösner, Edward Arnold, Arno Paessens, Jorg-Peter Kleim

Publikováno v: Proceedings of the National Academy of Sciences. 93:34-38

The quinoxaline nonnucleoside RT inhibitor (NNRTI) (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4- dihydroquinoxaline-2(1H)-thione (HBY 097) was used to select for drug-resistant HIV-1 variants in vitro. The viruses first developed mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdd7089bd332ff10f9b78508a768626d
https://doi.org/10.1073/pnas.93.1.34

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The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

Autor: Stephen H. Hughes, Paul L. Boyer, Arthur D. Clark, Jianping Ding, Manfred Rösner, Paul J. Lewi, Kalyan Das, Paul A. J. Janssen, Jorg-Peter Kleim, Y. Hsiou, Edward Arnold

Publikováno v: Journal of molecular biology. 309(2)

Inhibitors of human immunodeficiency virus (HIV) reverse transcriptase (RT) are widely used in the treatment of HIV infection. Loviride (an alpha-APA derivative) and HBY 097 (a quinoxaline derivative) are two potent non-nucleoside RT inhibitors (NNRT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ef6b17c765fdd8d9b1275d9257b13e
https://pubmed.ncbi.nlm.nih.gov/11371163

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