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Akademický článek

Fatty Liver Due to Increased de novo Lipogenesis: Alterations in the Hepatic Peroxisomal Proteome

Autor: Birgit Knebel, Pia Fahlbusch, Matthias Dille, Natalie Wahlers, Sonja Hartwig, Sylvia Jacob, Ulrike Kettel, Martina Schiller, Diran Herebian, Cornelia Koellmer, Stefan Lehr, Dirk Müller-Wieland, Jorg Kotzka

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 7 (2019)

In non-alcoholic fatty liver disease (NAFLD) caused by ectopic lipid accumulation, lipotoxicity is a crucial molecular risk factor. Mechanisms to eliminate lipid overflow can prevent the liver from functional complications. This may involve increased

Externí odkaz: https://doaj.org/article/3ae20d42e6e14044bf23c602018ccb0b

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Akademický článek

Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity.

Autor: Jorg Kotzka, Birgit Knebel, Jutta Haas, Lorena Kremer, Sylvia Jacob, Sonja Hartwig, Ulrike Nitzgen, Dirk Muller-Wieland

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32609 (2012)

The transcription factor sterol regulatory element binding protein (SREBP)-1a plays a pivotal role in lipid metabolism. Using the SREBP-1a expressing human hepatoma cell line HepG2 we have shown previously that human SREBP-1a is phosphorylated at ser

Externí odkaz: https://doaj.org/article/b52abde8b11944ba986e7eb1ed77dd87

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Akademický článek

Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass.

Autor: Birgit Knebel, Jutta Haas, Sonja Hartwig, Sylvia Jacob, Cornelia Köllmer, Ulrike Nitzgen, Dirk Muller-Wieland, Jorg Kotzka

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31812 (2012)

The pathogenesis of fatty liver is not understood in detail, but lipid overflow as well as de novo lipogenesis (DNL) seem to be the key points of hepatocyte accumulation of lipids. One key transcription factor in DNL is sterol regulatory element-bind

Externí odkaz: https://doaj.org/article/e3d86e993ed84c28b063bbd67ac28918

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Association of cardiac autonomic dysfunction with higher levels of plasma lipid metabolites in recent-onset type 2 diabetes

Autor: Dan Ziegler, Jorg Kotzka, Alexander Strom, Michael Roden, Klaus Straßburger, Gidon J. Bönhof, Birgit Knebel, Julia Szendroedi

Publikováno v: Diabetologia

Aims/hypothesis Emerging evidence suggests that in addition to hyperglycaemia, dyslipidaemia could represent a contributing pathogenetic factor to diabetic neuropathy, while obesity and insulin resistance play a role in the development of diabetic ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957da4a18db4cc56bc8e86d21aecc653
https://doi.org/10.1007/s00125-020-05310-5

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The RabGAPs TBC1D1 and TBC1D4 Control Uptake of Long-Chain Fatty Acids Into Skeletal Muscle via Fatty Acid Transporter SLC27A4/FATP4

Autor: Jorg Kotzka, Hadi Al-Hasani, Zhou Zhou, Frank Müller, Tim Benninghoff, Sandra Cames, Hannah Batchelor, Alexandra Chadt, Samaneh Eickelschulte, Christina Schöndeling, Isabelle Sinowenka, Lena Espelage, Isabel Zeinert

Publikováno v: Diabetes. 69:2281-2293

The two closely related RabGTPase-activating proteins (RabGAPs) TBC1D1 and TBC1D4 play a crucial role in the regulation of GLUT4 translocation in response to insulin and contraction in skeletal muscle. In mice, deficiency in one or both RabGAPs leads

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d2b99d5bf55e14e40f262f882e57a4
https://doi.org/10.2337/db20-0180

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Expansion and Impaired Mitochondrial Efficiency of Deep Subcutaneous Adipose Tissue in Recent-Onset Type 2 Diabetes

Publikováno v: The Journal of Clinical Endocrinology and Metabolism

Context/Objective Impaired adipose tissue (AT) function might induce recent-onset type 2 diabetes (T2D). Understanding AT energy metabolism could yield novel targets for the treatment of T2D. Design/Patients Male patients with recently-diagnosed T2D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3bdef883bf202dd85471ea3c912631
https://doi.org/10.1210/clinem/dgz267

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Preparation of 'Functional' Mitochondria: A Challenging Business

Autor: Stefan, Lehr, Sonja, Hartwig, Jorg, Kotzka

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2276

As the powerhouse of the cell, mitochondria, plays a crucial role in many aspects of life, whereby mitochondrial dysfunctions are associated with pathogenesis of many diseases, like neurodegenerative diseases, obesity, cancer, and metabolic as well a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::05707477ee7bf4780b3dc36f71fe1624
https://pubmed.ncbi.nlm.nih.gov/34060030

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