Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Jorg Kotzka"'
Autor:
Birgit Knebel, Pia Fahlbusch, Matthias Dille, Natalie Wahlers, Sonja Hartwig, Sylvia Jacob, Ulrike Kettel, Martina Schiller, Diran Herebian, Cornelia Koellmer, Stefan Lehr, Dirk Müller-Wieland, Jorg Kotzka
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
In non-alcoholic fatty liver disease (NAFLD) caused by ectopic lipid accumulation, lipotoxicity is a crucial molecular risk factor. Mechanisms to eliminate lipid overflow can prevent the liver from functional complications. This may involve increased
Externí odkaz:
https://doaj.org/article/3ae20d42e6e14044bf23c602018ccb0b
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8778 (2020)
Lipodystrophies are a heterogeneous group of physiological changes characterized by a selective loss of fatty tissue. Here, no fat cells are present, either through lack of differentiation, loss of function or premature apoptosis. As a consequence, l
Externí odkaz:
https://doaj.org/article/411ccc0ab8044b1ea0c700730b807b57
Autor:
Pia Fahlbusch, Birgit Knebel, Tina Hörbelt, David Monteiro Barbosa, Aleksandra Nikolic, Sylvia Jacob, Hadi Al-Hasani, Frederique Van de Velde, Yves Van Nieuwenhove, Dirk Müller-Wieland, Bruno Lapauw, D. Margriet Ouwens, Jorg Kotzka
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 4144 (2020)
Fatty liver occurs from simple steatosis with accumulated hepatic lipids and hepatic insulin resistance to severe steatohepatitis, with aggravated lipid accumulation and systemic insulin resistance, but this progression is still poorly understood. An
Externí odkaz:
https://doaj.org/article/e4f7ea6a902c482d82d941503545562e
Autor:
Birgit Knebel, Sonja Hartwig, Sylvia Jacob, Ulrike Kettel, Martina Schiller, Waltraud Passlack, Cornelia Koellmer, Stefan Lehr, Dirk Müller-Wieland, Jorg Kotzka
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 980 (2018)
The key lipid metabolism transcription factor sterol regulatory element-binding protein (SREBP)-1a integrates gene regulatory effects of hormones, cytokines, nutrition and metabolites as lipids, glucose, or cholesterol via phosphorylation by differen
Externí odkaz:
https://doaj.org/article/6d169fe9e38347b1993b3ed958433c0c
Autor:
Birgit Knebel, Simon Goeddeke, Gereon Poschmann, Daniel F. Markgraf, Sylvia Jacob, Ulrike Nitzgen, Waltraud Passlack, Christina Preuss, Hans-Dieter Dicken, Kai Stühler, Sonja Hartwig, Stefan Lehr, Jorg Kotzka
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1928 (2017)
The group of adipokines comprises hundreds of biological active proteins and peptides released from adipose tissue. Alterations of those complex protein signatures are suggested to play a crucial role in the pathophysiology of multifactorial, metabol
Externí odkaz:
https://doaj.org/article/6983ec1d82cf4aed847dcda352f3fbdd
Autor:
Jorg Kotzka, Birgit Knebel, Jutta Haas, Lorena Kremer, Sylvia Jacob, Sonja Hartwig, Ulrike Nitzgen, Dirk Muller-Wieland
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32609 (2012)
The transcription factor sterol regulatory element binding protein (SREBP)-1a plays a pivotal role in lipid metabolism. Using the SREBP-1a expressing human hepatoma cell line HepG2 we have shown previously that human SREBP-1a is phosphorylated at ser
Externí odkaz:
https://doaj.org/article/b52abde8b11944ba986e7eb1ed77dd87
Autor:
Birgit Knebel, Jutta Haas, Sonja Hartwig, Sylvia Jacob, Cornelia Köllmer, Ulrike Nitzgen, Dirk Muller-Wieland, Jorg Kotzka
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31812 (2012)
The pathogenesis of fatty liver is not understood in detail, but lipid overflow as well as de novo lipogenesis (DNL) seem to be the key points of hepatocyte accumulation of lipids. One key transcription factor in DNL is sterol regulatory element-bind
Externí odkaz:
https://doaj.org/article/e3d86e993ed84c28b063bbd67ac28918
Autor:
Dan Ziegler, Jorg Kotzka, Alexander Strom, Michael Roden, Klaus Straßburger, Gidon J. Bönhof, Birgit Knebel, Julia Szendroedi
Publikováno v:
Diabetologia
Aims/hypothesis Emerging evidence suggests that in addition to hyperglycaemia, dyslipidaemia could represent a contributing pathogenetic factor to diabetic neuropathy, while obesity and insulin resistance play a role in the development of diabetic ca
Autor:
Jorg Kotzka, Hadi Al-Hasani, Zhou Zhou, Frank Müller, Tim Benninghoff, Sandra Cames, Hannah Batchelor, Alexandra Chadt, Samaneh Eickelschulte, Christina Schöndeling, Isabelle Sinowenka, Lena Espelage, Isabel Zeinert
Publikováno v:
Diabetes. 69:2281-2293
The two closely related RabGTPase-activating proteins (RabGAPs) TBC1D1 and TBC1D4 play a crucial role in the regulation of GLUT4 translocation in response to insulin and contraction in skeletal muscle. In mice, deficiency in one or both RabGAPs leads
Autor:
Eckhard Lammert, Martin Wolkersdorfer, C. Herder, Tomas Jelenik, Karsten Müssig, Jesper Lundbom, Bengt-Frederik Belgardt, Daniel F. Markgraf, Yanislava Karusheva, Dan Ziegler, J Szendroedi, Meriem Ouni, Julia Szendroedi, Yuliya Kupriyanova, Wolfgang Rathmann, Jorg Kotzka, K Müssig, Kálmán Bódis, Andrea Icks, Michael Roden, Jong-Hee Hwang, Volker Burkart, Annette Schürmann, Oliver Kuss, Hadi Al-Hasani, Gerd Geerling, D Markgraf, M Roden, Anette E. Buyken, JH Hwang, Oana-Patricia Zaharia, Alexander Strom
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context/Objective Impaired adipose tissue (AT) function might induce recent-onset type 2 diabetes (T2D). Understanding AT energy metabolism could yield novel targets for the treatment of T2D. Design/Patients Male patients with recently-diagnosed T2D