Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jorg H. W. Distler"'
Autor:
Laura Duffy, John Henderson, Max Brown, Stefan Pryzborski, Nicola Fullard, Lena Summa, Jorg H. W. Distler, Richard Stratton, Steven O’Reilly
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
ObjectiveSystemic Sclerosis is an autoimmune connective tissue disease which results in fibrosis of the skin and lungs. The disease is characterized by activation of myofibroblasts but what governs this is unknown. Gremlin-1 is a BMP antagonist that
Externí odkaz:
https://doaj.org/article/8dfcf453f2c84f50a25fec4f55d27583
Autor:
Xiangguang Shi, Yahui Chen, Mengkun Shi, Fei Gao, Lihao Huang, Wei Wang, Dong Wei, Chenyi Shi, Yuexin Yu, Xueyi Xia, Nana Song, Xiaofeng Chen, Jörg H. W. Distler, Chenqi Lu, Jingyu Chen, Jiucun Wang
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Pulmonary fibrosis (PF) is a severe pulmonary disease with limited available therapeutic choices. Recent evidence increasingly points to abnormal lipid metabolism as a critical factor in PF pathogenesis. Our latest research identifies the dy
Externí odkaz:
https://doaj.org/article/4d9bf9c18f6f41499b6b70bf0e68e597
Autor:
Norbert Blank, Marc Schmalzing, Pia Moinzadeh, Max Oberste, Elise Siegert, Ulf Müller-Ladner, Gabriela Riemekasten, Claudia Günther, Ina Kötter, Gabriele Zeidler, Christiane Pfeiffer, Aaron Juche, Ilona Jandova, Jan Ehrchen, Laura Susok, Tim Schmeiser, Cord Sunderkötter, Jörg H. W. Distler, Margitta Worm, Alexander Kreuter, Gernot Keyßer, Hanns-Martin Lorenz, Thomas Krieg, Nicolas Hunzelmann, Jörg Henes, on behalf of the German Network for Systemic Sclerosis
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-10 (2022)
Abstract Background Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell therapy (HSCT) can be a rescue therapy for patients with rapidly progressive SSc. Objectives To assess the safet
Externí odkaz:
https://doaj.org/article/6ec913da57ed47739231cbf489c0fd42
Autor:
Masahiro Kondo, Tsuyoshi Suzuki, Yuko Kawano, Shinji Kojima, Masahiko Miyashiro, Atsuhiro Matsumoto, Gabriela Kania, Przemysław Błyszczuk, Rebecca L. Ross, Panji Mulipa, Francesco Del Galdo, Yun Zhang, Jörg H. W. Distler
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-17 (2022)
Abstract Background Activation of melanocortin 1 receptor (MC1R) is known to exert broad anti-inflammatory and anti-fibrotic effects. The purpose of this study is to investigate the potential of dersimelagon, a novel oral MC1R agonist, as a therapeut
Externí odkaz:
https://doaj.org/article/4359e25614b54dcda62a5b4e9a9fd00b
Autor:
Yi-Nan Li, Chih-Wei Chen, Thuong Trinh-Minh, Honglin Zhu, Alexandru-Emil Matei, Andrea-Hermina Györfi, Frederic Kuwert, Philipp Hubel, Xiao Ding, Cuong Tran Manh, Xiaohan Xu, Christoph Liebel, Vladyslav Fedorchenko, Ruifang Liang, Kaiyue Huang, Jens Pfannstiel, Min-Chuan Huang, Neng-Yu Lin, Andreas Ramming, Georg Schett, Jörg H. W. Distler
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation. In inflammatory arthritis such as rheumatoid arthritis (RA), however, increased osteoclast differentiation and activit
Externí odkaz:
https://doaj.org/article/9ac47eda1306433987ca42044a6cf8fb
Autor:
Toby M. Maher, Arnaud Bourdin, Elizabeth R. Volkmann, Serena Vettori, Jörg H. W. Distler, Margarida Alves, Christian Stock, Oliver Distler
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background The forced vital capacity (FVC) of healthy individuals depends on their age, sex, ethnicity and height. Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is characterised by loss of FVC. We compared FVC values in t
Externí odkaz:
https://doaj.org/article/3c95eea0163d441fa7e873d6fac37d1a
Autor:
Jutta G. Richter, Tim Filla, Hasan Acar, Ellen Bleck, Anna Kernder, Christina Düsing, Stefan Vordenbäumen, Markus Schröder, Ralf Hansen, Jörg H. W. Distler, Matthias Schneider
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundBiobanks are essential structures for scientific research. The RHINEVIT biobank is used to recruit biomaterials from rheumatology patients in outpatient care and to conduct clinical research studies (e.g., cohort studies) and basic research
Externí odkaz:
https://doaj.org/article/08e1aaeebb284c27b6038c936fe9774e
Autor:
Hana Štorkánová, Lenka Štorkánová, Adéla Navrátilová, Viktor Bečvář, Hana Hulejová, Sabína Oreská, Barbora Heřmánková, Maja Špiritović, Radim Bečvář, Karel Pavelka, Jiří Vencovský, Jörg H. W. Distler, Ladislav Šenolt, Michal Tomčík
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2736 (2023)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/5cb0e2c586d14d5590ea13801e94857f
Autor:
Kerry L. M. Ralph, Mark Panzenbeck, Haiguang Xiao, Lee Frego, Tammy Bigwarfe, Erica Waltz, Christine Grimaldi, Kathy Last-Barney, Don Souza, Scott Brodeur, Gerald Nabozny, Jay S. Fine, Jorg H. W. Distler, Meera Ramanujam
Publikováno v:
The Journal of Immunology. 196:70.19-70.19
Targeting CD40-CD40L interactions has been an interesting drug concept for the treatment of autoimmune diseases given this pathway’s role in the development of both humoral and cell mediated immune responses. While preclinical blockade of CD40L is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7a6c1ff851a90799154c339ba0d6cf8
https://doi.org/10.4049/jimmunol.196.supp.70.19
https://doi.org/10.4049/jimmunol.196.supp.70.19
Autor:
Roger Hesselstrand, Jörg H. W. Distler, Gabriela Riemekasten, Dirk M. Wuttge, Marie Törngren, Helén C. Nyhlén, Fredrik Andersson, Helena Eriksson, Birgitta Sparre, Helén Tuvesson, Oliver Distler
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Objectives To evaluate the changes in disease-related biomarkers and safety of paquinimod, an oral immunomodulatory compound, in patients with systemic sclerosis (SSc). Methods In this open-label, single-arm, multicenter study, SSc patients
Externí odkaz:
https://doaj.org/article/d207744d1b7440a2942ff4c90c93c762